ABSTRACT
Of 334 mature breeding guineapigs, 53 (15.9%) died in a disease outbreak involving Salmonella typhimurium serotypes 1, 4, 5 and 12 : i : 1,2. The uterus was consistently involved. Nine other Salmonella-free mature female guineapigs when inoculated with a pure isolate from the outbreak, using the subcutaneous, intramuscular or per os route, succumbed to salmonellosis, reproducing signs and lesions observed during the outbreak. Abortion was not recorded during the outbreak despite many pregnant sows being affected. The isolate was sensitive to gentamicin, tetracycline, ampicillin and cefuroxime but resistant to co-trimoxazole, erythromycin and penicillin.
Subject(s)
Guinea Pigs/microbiology , Salmonella Infections, Animal/epidemiology , Uterine Diseases/veterinary , Animals , Disease Outbreaks/veterinary , Female , Male , Pregnancy , Rodent Diseases/epidemiology , Rodent Diseases/microbiology , Rodent Diseases/pathology , Salmonella Infections, Animal/pathology , Salmonella typhimurium/isolation & purification , Uterine Diseases/microbiology , Uterine Diseases/pathologyABSTRACT
An epizootic infection of Citrobacter freundii in a guineapig colony is reported. From 1300 guineapigs maintained in a colony, a total of 115 guineapigs died. Lesions found postmortem were suggestive of acute pneumonia and enteritis. Citrobacter freundii was consistently isolated from necropsy specimens of lung, liver, spleen and intestines of the animals. The source of infection was not ascertained.
Subject(s)
Disease Outbreaks/veterinary , Enterobacteriaceae Infections/veterinary , Guinea Pigs , Rodent Diseases/epidemiology , Animals , Citrobacter/isolation & purification , Enterobacteriaceae Infections/epidemiology , Guinea Pigs/microbiology , NigeriaABSTRACT
Shigellosis due to Shigella dysenteriae was diagnosed in an adult male captive chimpanzee (Pan troglodytes) which died suddenly after a brief recovery from illness lasting at least 3 wk. Confirmatory diagnosis was based on postmortem examination and cultural isolation of Shigella dysenteriae from the intestine, liver, lung, spleen and heart blood.
Subject(s)
Dysentery, Bacillary/veterinary , Pan troglodytes , Animals , Animals, Zoo , Male , Nigeria , Shigella dysenteriae/isolation & purificationABSTRACT
The acute toxicity of glycerol was studied in swiss albino rats. The median lethal dose (LD50) of glycerol in the local strain of swiss albino was determined to be 4.42 gm/kg body weight. Nervous signs were observed in the rats before death. Organ: body weight ratios of the heart, kidneys and liver were higher than normal, while those of the spleen and brain remained normal. No gross pathological lesion of these organs was observed. The histopathological lesions observed include congestion of blood vessels of the lungs and kidneys; accumulation of hemoglobin in renal tubules; renal tubular epithelial degeneration and desquamation; neuronal degeneration and necrosis, as well as occurrence of haemosiderin pigments.
