1.
J Nat Prod
; 74(3): 357-64, 2011 Mar 25.
Article
in English
| MEDLINE
| ID: mdl-21250701
ABSTRACT
Ciguatoxins, the principal causative toxins of ciguatera seafood poisoning, are large ladder-like polycyclic ethers. We report a highly stereoselective 6-exo radical cyclization/ring-closing olefin metathesis sequence to construct the syn/trans-fused polyether system. The new method was applied to the practical synthesis of ciguatoxin CTX3C.