ABSTRACT
Some 1,5-diaryl-3-ethoxycarbonyl-2-methylpyrrole derivatives were obtained by reacting 1-aryl-3-ethoxycarbonylpent-1,4-diones and a suitable aniline derivative or sulfanilamide under Paal-Knorr pyrrole synthesis conditions. The cytotoxicity of the compounds was tested and all compounds, except for compound 2 h, showed a time-dependent increase in cytotoxic activity. Analgesic activities of the compounds were determined by using the tail-flick and tail-immersion methods; some of the compounds showed potent analgesic activity.
Subject(s)
Analgesics , Cell Proliferation/drug effects , Pyrroles , Tail/drug effects , Analgesics/chemical synthesis , Analgesics/chemistry , Analgesics/pharmacology , Animals , Cells, Cultured , Embryo, Mammalian/cytology , Embryo, Mammalian/drug effects , Female , Fibroblasts/cytology , Fibroblasts/drug effects , Male , Mice , Pyrroles/chemical synthesis , Pyrroles/chemistry , Pyrroles/pharmacology , RatsABSTRACT
In this study, some aryl [3-(imidazol-1-yl/triazol-1-ylmethyl)benzofuran-2-yl] ketones, aryl (3-methyl-benzofuran-2-yl) ketoximes and aryl [3-(imidazol-1-yl/triazol-1-ylmethyl)benzofuran-2-yl] ketoximes were synthesised starting from 2-aryloyl-3-methyl-benzofuranes. The structure elucidation of the compounds was performed by IR, 1H-NMR, MASS spectroscopy and elemental analyses. Antifungal activities of the compounds were examined and moderate activity was obtained.
Subject(s)
Antifungal Agents/chemical synthesis , Antifungal Agents/pharmacology , Azoles/chemistry , Benzofurans/chemistry , Imidazoles/chemistry , Oximes/chemistry , Oximes/pharmacology , Antifungal Agents/chemistry , Candida/drug effects , Methylation , Molecular Structure , Oximes/chemical synthesis , Structure-Activity RelationshipABSTRACT
In this study, some aryl (3-methyl-benzofuran-2-yl) ketoximes and their ethers and esters were synthesised. The structure elucidation of the compounds was performed by IR, 1H-NMR, MASS spectroscopy and elemental analyses. Antifungal activities of the compounds were examined and moderate activity was obtained.
Subject(s)
Antifungal Agents/chemical synthesis , Benzofurans/chemical synthesis , Oximes/chemical synthesis , Antifungal Agents/pharmacology , Benzofurans/pharmacology , Microbial Sensitivity Tests/statistics & numerical data , Oximes/pharmacologyABSTRACT
In this study, some aryl(benzofuran-2-yl)ketoximes and their ethers and esters were synthesised. The structure elucidation of the compounds was performed by IR, 1H NMR and mass spectroscopic data and elemental analyses results. Antifungal activities of the compounds were examined and notable activity was obtained.
