ABSTRACT
Two new crystallographically characterized samarium complexes, [Sm(fod)3(L1)] (1) and [Sm(fod)3(L2)] (2) {L1 = 4,7-diphenyl-1,10-phenanthroline (bath), L2 = 2,2':6',2''-terpyridine and fod = anion of 6,6,7,7,8,8,8-heptafluoro-2,2-dimethyl-3,5-octanedione (Hfod)}, were synthesized and thoroughly characterized. Single-crystal (SC) analysis shows that complex 1 is an eight-coordinate structure with a distorted square antiprism geometry (D4d), whereas complex 2 possesses a nine-coordinate structure with distorted muffin geometry (Cs). The NMR results are in line with SC-XRD analysis, which further validate that the complexes remain intact in solutions. The photophysical characteristics of the complexes were studied in both visible and near infra-red (NIR) regions. The PLQY values of the present complexes were found to be higher than those reported in the literature except for a tetrakis Sm complex. This result indicates that both the ligands act as effective antennas for the present systems. A comparison of PLQY and emission lifetime values within the present complexes (in solid state) reveals that energy transfer from terpy to Sm3+ is more effective than that from the bath ligand. Various color parameters of the complexes were calculated, and the determined CCT values suggest that the complexes may be used as warm light sources. The determined band gap values for the complexes are in the range of those for semiconductors, which suggest the application of present systems in the field of optoelectronics. The curve between the emission intensity and temperature for complex 1 shows a perfect linearity (χ2 = 0.99), which suggests that this complex can have potential application as a temperature sensor in the range 60-350 K.
ABSTRACT
In this study, we investigated a new series of naphthalimide based Schiff base compounds as potential DNA binding, antioxidant and antimicrobial agents. The structural characterization of synthesized compounds was carried out with the aid of elemental analysis and spectroscopic techniques (UV-vis., IR, (1)H and (13)C NMR). The DNA binding properties of target compounds against Ct-DNA (calf thymus) have been investigated in detail by numerous biophysical techniques (UV-vis, fluorescence, ethidium bromide displacement assay, Time resolved fluorescence, viscosity, cyclic voltammetry and circular dichorism) and the evidences have suggested that the test compounds could interact with DNA via intercalative binding. The extent of DNA binding (Kb) of these compounds follow the order of 3b (3.33 × 10(4) M(-1)) > 3a (2.25 × 10(4) M(-1)) > 3c (2 × 10(4) M(-1)), suggesting that compound 3b binds more strongly to Ct- DNA than the compounds 3a and 3c. Molecular docking results further support intercalative binding of test compounds with DNA. The binding energies of docked compounds (3a-3c) were found to be -8.20 to -8.69 kcal/ mol, suggesting greater binding affinity to Ct-DNA. The synthesized compounds displayed potential antimicrobial activities against Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae and Salmonella typhimurium. Compound 3c has emerged as most active against all the four tested bacterial strains with MIC value in the range of 0.031-0.062 mg/mL. In the mutagenicity studies, all the test compounds were found to be non-mutagenic both in the presence and absence of metabolic activation. Furthermore, the antioxidant activity experiments show that these compounds exhibited potential scavenging activities against DPPH and H2O2 radicals.
