1.
Orv Hetil
; 136(3): 129-33, 1995 Jan 15.
Article
in Hungarian
| MEDLINE
| ID: mdl-7870410
ABSTRACT
OBJECTIVE: Synthesize such hybrid peptides, which contain the RGD (Arg-Gly-Asp) sequence coupled with another peptide containing lysine residues in special positions, to inhibit simultaneously platelet activation and promote fibrinolytic processes. DESIGN: The in vitro haemostasis modifying properties of the synthesized peptides were tested with ADP induced platelet aggregation, in vitro plasmin generation tests and fibrin-clot lysis assays. RESULTS AND CONCLUSIONS: RGDF (Arg-Gly-Asp-Phe) coupled with the carboxyterminal antiplasmin peptide (RGDFAP hybrid molecule) has a common concentration range for inhibiting platelet activation and increase plasmin generation along with accelerated in vitro fibrin-clot lysis.