[Toothpastes of the «Mexidol dent¼ line - parapharmaceuticals with stable antioxidative activity]. / Zubnye pasty lineiki «MEXIDOL dent¼ ­ parafarmatsevticheskie preparaty s ustoichivoi antioksidantnoi aktivnost'yu.

THE AIM OF THE STUDY: Was to assess the stability of antioxidative activity of the active compound 2-ethyl-6-methylpiridine-3-ol succinate of toothpastes of the «Mexidol dent¼ line. MATERIALS AND METHODS: The study involved toothpastes of «MEXIDOL dent¼ line: MEXIDOL dent Aktiv MEXIDOL dent Complex, MEXIDOL dent Sensitive, MEXIDOL dent Fito, MEXIDOL dent Teens, MEXIDOL dent Professional White. Features of 2-ethyl-6-methylpiridine-3-ol succinate («MEXIDOL¼) determined the choice of potentiometric titration method for the assessment of the stability of antioxidative activity. RESULTS AND CONCLUSION: The study confirmed the stability of antioxidative activity of the active compound 2-ethyl-6-methylpiridine-3-ol succinate of toothpastes of the «Mexidol dent¼ line during shelf life.

[Comparative analysis of Kameton spraying parameters of different manufacturers]. / Sravnitel'nyi analiz pokazatelei raspyleniia preparatov Kameton raznykh proizvoditelei.

PURPOSE: Based on a comparative analysis of the key dispersion parametries of spray-aerosol forms of drugs Kameton from different manufacturers the most effective drug in terms of delivery to the mucous membrane of the throat was choosen. MATERIAL AND METHODS: The objects of study were 5 drugs brand Kameton, produced in the form of a metered-dose spray manufacturers of 'Firm 'VIPSMED' (RF), 'Altayvitaminy' (RF), 'Samaramedprom' (RF), 'ESCO-Pharm' (Armenia) and metered-dose aerosol - of 'Pharmstandard' (RF). Measurement of the dynamic characteristics of the spray and the dispersed composition of the spray was carried out by the method of shadow photography with digital image processing using the 'POLIS' system. RESULTS: Diagnose spray pattern spray angle and the shape of the cone spray pattern showed that the spray pattern is in the form of a wide hollow cone is in the drugs Kameton production of 'Firm 'VIPSME' and 'ESCO-Pharm' (Armenia). The study of the parameter 'spray duration' showed that in all studied sprays the classical three-stage spray is carried out. In the aerosol production of 'Pharmstandard' no initial and final stage, spraying takes place in jet, without forming a cone. The calculation of the proportion of the duration of the main stage to the total duration of the spray showed that the maximum value of this parameter is achieved in the spray production of 'Firm 'VIPSMED'. A comparison of five drugs Kameton dispersed composition showed that the drug Kameton production of 'Pharmstandard' refers to the fine, and the others studied - to the coarse aerosols, which is more preferable. CONCLUSION: A comparative analysis of the drugs Kameton five different manufacturers showed that the most effective mode of operation of the spray packaging system, providing the most favorable conditions for the delivery of the drug to the mucous membrane of the throat, is carried out in drug production of 'Firm 'VIPSMED'.

[A COMPARATIVE ANALYSIS OF THE DISPERSION QUALITY OF NASAL SPRAYS OXYMETAZOLINE].

The subject matter of the investigation is to compare the metered dose nasal sprays containing the long-acting decongestant oxymetazoline from the different manufacturers according to the dispersion quality: the dose quantity in one packing, the dose mass reproducibility, imprint area on the planar imitation model. The tests were conducted: «The number of doses per package¼, «Mass uniformity of the dose¼, «Irrigated area (on the planar imitation model)¼. The analysis of nine oxymetazoline nasal sprays demonstrates that the optimal result is achieved while usingVicks Sinex.