Subject(s)
Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Cellulitis/etiology , Eosinophilia/etiology , Leukemia, Lymphocytic, Chronic, B-Cell/complications , Cellulitis/diagnosis , Cellulitis/drug therapy , Cellulitis/pathology , Eosinophilia/diagnosis , Eosinophilia/drug therapy , Eosinophilia/pathology , Humans , Leukemia, Lymphocytic, Chronic, B-Cell/drug therapy , Male , Middle Aged , Skin/pathology , Treatment Outcome , Upper ExtremitySubject(s)
Melanoma/complications , Melanosis/diagnostic imaging , Nail Diseases/diagnostic imaging , Skin Neoplasms/complications , Aged , Dermoscopy , Diagnosis, Differential , Female , Humans , Melanoma/pathology , Melanoma/surgery , Melanosis/etiology , Melanosis/pathology , Melanosis/surgery , Nail Diseases/etiology , Nail Diseases/pathology , Nail Diseases/surgery , Nails/cytology , Nails/pathology , Skin/cytology , Skin/pathology , Skin Neoplasms/pathology , Skin Neoplasms/surgery , Treatment OutcomeSubject(s)
Macrophages/pathology , Melanosis/pathology , Skin Neoplasms/complications , Skin/pathology , Antigens, CD/metabolism , Antigens, Differentiation, Myelomonocytic/metabolism , Antineoplastic Agents, Immunological/therapeutic use , Groin , Humans , Lymphatic Metastasis/diagnostic imaging , Macrophages/immunology , Male , Melanins/metabolism , Melanosis/etiology , Melanosis/immunology , Middle Aged , Nivolumab/therapeutic use , Receptors, Cell Surface/metabolism , Skin/cytology , Skin Neoplasms/diagnostic imaging , Skin Neoplasms/pathology , Skin Neoplasms/therapy , Tomography, X-Ray ComputedSubject(s)
Immunoglobulin A/analysis , Leukemia, Myeloid, Acute/pathology , Myelodysplastic Syndromes/pathology , Vasculitis/pathology , Aged , Disease Progression , Humans , Leukemia, Myeloid, Acute/complications , Leukemia, Myeloid, Acute/immunology , Male , Myelodysplastic Syndromes/immunology , Vasculitis/etiology , Vasculitis/immunologySubject(s)
Dermatitis, Exfoliative/chemically induced , Drug Eruptions/etiology , Hand-Foot Syndrome/etiology , Adult , Antimetabolites, Antineoplastic , Antineoplastic Combined Chemotherapy Protocols/adverse effects , Colonic Neoplasms/drug therapy , Drug Combinations , Drug Eruptions/pathology , Fluorouracil/adverse effects , Humans , Leucovorin/adverse effects , Liver Neoplasms/drug therapy , Liver Neoplasms/secondary , Male , Organoplatinum Compounds/adverse effects , Oxonic Acid/adverse effects , Pyridines/adverse effects , Tegafur/adverse effectsSubject(s)
Antineoplastic Agents/adverse effects , Drug Eruptions/etiology , Melanoma/drug therapy , Panniculitis/chemically induced , Skin Neoplasms/drug therapy , Vasculitis/chemically induced , Vemurafenib/adverse effects , Acetaminophen/therapeutic use , Aged , Analgesics, Non-Narcotic/therapeutic use , Anti-Inflammatory Agents, Non-Steroidal/therapeutic use , Celecoxib/therapeutic use , Drug Eruptions/drug therapy , Drug Eruptions/pathology , Humans , Male , Melanoma/secondary , Neutrophils/pathology , Panniculitis/drug therapy , Panniculitis/pathology , Skin Neoplasms/pathologySubject(s)
Klippel-Trenaunay-Weber Syndrome/diagnosis , Mongolian Spot/diagnosis , Neurocutaneous Syndromes/diagnosis , Nevus, Pigmented/diagnosis , Skin Neoplasms/diagnosis , Diagnosis, Differential , Humans , Klippel-Trenaunay-Weber Syndrome/pathology , Male , Middle Aged , Mongolian Spot/pathology , Neurocutaneous Syndromes/pathology , Nevus of Ota/diagnosis , Nevus of Ota/pathology , Skin Neoplasms/pathologySubject(s)
Behcet Syndrome/complications , Muscle, Skeletal/diagnostic imaging , Myalgia/etiology , Myositis/diagnosis , Skin Diseases, Vascular/etiology , Thrombophlebitis/diagnostic imaging , Adolescent , Diagnosis, Differential , Humans , Leg , Magnetic Resonance Imaging , Male , Thrombophlebitis/etiologySubject(s)
Hair Diseases/diagnostic imaging , Pilomatrixoma/diagnostic imaging , Skin Neoplasms/diagnostic imaging , Skin Ulcer/diagnostic imaging , Adult , Diagnosis, Differential , Fluorodeoxyglucose F18/administration & dosage , Hair Diseases/pathology , Humans , Leg , Male , Pilomatrixoma/pathology , Positron Emission Tomography Computed Tomography , Radiopharmaceuticals/administration & dosage , Skin/diagnostic imaging , Skin/pathology , Skin Neoplasms/pathology , Skin Ulcer/pathologySubject(s)
Cellulitis/diagnosis , Lymphoma, Extranodal NK-T-Cell/pathology , Nose Neoplasms/pathology , Skin Neoplasms/diagnosis , Skin Neoplasms/secondary , Diagnosis, Differential , Humans , Leg/pathology , Lymphoma, Extranodal NK-T-Cell/therapy , Male , Middle Aged , Nasal Cavity/pathology , Nose Neoplasms/therapy , Skin Neoplasms/drug therapySubject(s)
Bowen's Disease/diagnosis , Erythema/diagnosis , Paget Disease, Extramammary/diagnosis , Skin Neoplasms/diagnosis , Abdominal Wall/pathology , Biopsy, Needle , Bowen's Disease/pathology , Dermoscopy/methods , Diagnosis, Differential , Female , Humans , Immunohistochemistry , Middle Aged , Paget Disease, Extramammary/pathology , Skin Neoplasms/pathologyABSTRACT
Nevus sebaceous is known by its association with one or more secondary tumors, but more than three multiple tumors arising from a nevus sebaceous is extremely rare. A 67-year-old female presented with a light brown plaque on the back of her head that contained a dome-shaped black node and an erosive lesion. Histopathological examination showed atypical basaloid cells in the black node. At the periphery of that node, structures resembling follicular germs extruded from interlacing cords in the upper portion and tumor nests with sebocytes were in the lower portion. In the erosive lesion, papillated structures with an apocrine epithelium were observed. In the light brown plaque, enlargement of sebaceous lobules was noted. From those histopathological features, a diagnosis of syringocystadenoma papilliferum, sebaceoma, trichoblastoma and basal cell carcinoma arising from a nevus sebaceous was made. We discuss the rarity of multiple tumors arising from a nevus sebaceous.
ABSTRACT
A 50-year-old Japanese woman consulted the emergency department of our hospital for bleeding due to an intractable postoperative wound on the lower abdomen; the postoperative wound was owing to a laparoscopic cholecystectomy performed 1 year previously for acute cholecystitis. She presented with a painful ulcer on her right lower abdomen. She also presented with multiple scars, skin grafts on the extremities, and a missing left lower leg, the causes for all of which were unexplained. The results of her blood test were normal, except for the hemoglobin level. Histology of the skin biopsy specimen from the ulcer did not show any specific findings. The previous surgeon who had performed the laparoscopic cholecystectomy revealed that surgical wound dehiscence had occurred during her admission. After a body restraint had been applied, the ulcer improved. Medical records indicated that she had been admitted to the department of plastic surgery at our hospital for skin grafting of a leg ulcer. During that admission, she refused to consult with the department of psychiatry, al-though the staff suspected mental disorders. Therefore, we diagnosed her with cutaneous Munchausen syndrome. After vacuum-assisted closure (VAC) therapy had been performed to prevent her from traumatizing the ulcer again, it rapidly became granulated and reepithelialized. Munchausen syndrome is characterized by feigning physical symptoms to seek attention. Patients self-inflict numerous lesions, keep getting admitted to different hospitals, and feign acute illness, usually spectacular diseases. VAC therapy may be effective for preventing patients with cutaneous Munchausen syndrome from traumatizing their wounds.