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Bioorg Med Chem ; 14(15): 5397-401, 2006 Aug 01.
Article in English | MEDLINE | ID: mdl-16698270

ABSTRACT

The present study describes the chemical synthesis and pharmacological evaluation of a new series of eleven compounds stereoisomers of imidobenzenesulfonylaziridines in the forced-swimming test (FST) in mice. The pharmacological results of these compounds show that six of them, given intraperitoneally, reduced the immobility time of mice evaluated in the FST, an antidepressant-like profile of action similar to imipramine, a well-known standard antidepressant drug used for comparison, without compromising the animals' motor performance. The putative antidepressant-like action demonstrated here indicates their viability for the development of new therapeutic options for the treatment of depression.


Subject(s)
Antidepressive Agents/chemical synthesis , Antidepressive Agents/pharmacology , Aziridines/chemical synthesis , Aziridines/pharmacology , Depression/prevention & control , Sulfones/chemical synthesis , Sulfones/pharmacology , Swimming , Alkaloids/chemistry , Animals , Antidepressive Agents/chemistry , Aziridines/chemistry , Behavior, Animal/drug effects , Disease Models, Animal , Dose-Response Relationship, Drug , Imipramine/pharmacology , Immersion , Male , Mice , Molecular Structure , Motor Activity/drug effects , Phyllanthus/chemistry , Piperidones/chemistry , Stereoisomerism , Sulfones/chemistry
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