ABSTRACT
In 373 hospitalized patients with bacteriologically positive bile samples, the aetiology was clarified by laboratory methods in 80% of clinically verified gallbladder and biliary duct infections and in 15.5% of diseases related to the biliary duct. The relationship between anacidity and biliary duct infection and the high incidence of biliary duct infections at advanced age are pointed out. About 90% of the cultures yielded intestinal bacteria and in more than 50% of the bile samples, E. coli was present.
Subject(s)
Bile Ducts/microbiology , Biliary Tract Diseases/microbiology , Gallbladder Diseases/microbiology , Bacteria/isolation & purification , Bacterial Infections/complications , Biliary Tract Diseases/etiology , Cholecystitis/microbiology , Cholelithiasis/microbiology , Gallbladder Diseases/etiology , Gallbladder Neoplasms/microbiology , Hospitalization , HumansABSTRACT
The sensitivity to antibiotics of the various bacterium strains has been studied in the bile samples of 373 patients with gallbladder and/or biliary duct infection and the clinical effect of antibiotic therapy applied to 325 instances was recorded. The antibiograms suggested an increased resistance mainly of the intestinal bacteria isolated from the bile samples. An increase in the ratio of polyresistant strains was observed. Gentamycin, neomycin, polymixin and kanamycin were the most potent in vitro. Parenterally administered chloramphenicol and oxytetracycline acted favourable in most cases of biliary infection. This therapy was successful even against pathogens resistant in vitro to chloramphenicol and oxytetracycline. The higher efficacy of aimed antibiotic therapy compared to randomly applied treatment is stressed and confirmed by numerical data.
