ABSTRACT
OBJECTIVE: Ovarian cancer in Black women is common in many West African countries but is relatively rare in North America. Black women have worse survival outcomes when compared to White women. Ovarian cancer histotype, diagnosis, and age at presentation are known prognostic factors for outcome. We sought to conduct a preliminary comparative assessment of these factors across the African diaspora. METHODS: Patients diagnosed with ovarian cancer (all histologies) between June 2016-December 2019 in Departments of Pathology at 25 participating sites in Nigeria were identified. Comparative population-based data, inclusive of Caribbean-born Blacks (CBB) and US-born Blacks (USB), were additionally captured from the International Agency for Research on Cancer and Florida Cancer Data Systems. Histology, country of birth, and age at diagnosis data were collected and evaluated across the three subgroups: USB, CBB and Nigerians. Statistical analyses were done using chi-square and student's t-test with significance set at p<0.05. RESULTS: Nigerians had the highest proportion of germ cell tumor (GCT, 11.5%) and sex-cord stromal (SCST, 16.2%) ovarian cancers relative to CBB and USB (p=0.001). CBB (79.4%) and USB (77.3%) women were diagnosed with a larger proportion of serous ovarian cancer than Nigerians (60.4%) (p<0.0001). Nigerians were diagnosed with epithelial ovarian cancers at the youngest age (51.7± 12.8 years) relative to USB (58.9 ± 15.0) and CBB (59.0± 13.0,p<0.001). Black women [CBB (25.2 ± 15.0), Nigerians (29.5 ± 15.1), and USB (33.9 ± 17.9)] were diagnosed with GCT younger than White women (35.4 ± 20.5, p=0.011). Black women [Nigerians (47.5 ± 15.9), USB (50.9 ± 18.3) and CBB (50.9 ± 18.3)] were also diagnosed with SCST younger than White women (55.6 ± 16.5, p<0.01). CONCLUSION: There is significant variation in age of diagnosis and distribution of ovarian cancer histotype/diagnosis across the African diaspora. The etiology of these findings requires further investigation.
ABSTRACT
INTRODUCTION: Thyroid Cancer (TC) continues to be the most common endocrine cancer with a worldwide increase in incidence over the last three decades. This trend has been reported in all continents except Africa, where detection is adjudged to be insufficient, making it imperative for us to re-evaluate the patterns in our environment. AIM: To determine the patterns of TCs in Southeastern Nigeria. MATERIALS AND METHODS: This was a 15-year retrospective review of all thyroidectomy specimens received at the Depart-ment of Morbid Anatomy, University of Nigeria, Enugu Campus, Enugu, Nigeria. The age, sex and histologic subtypes of diagnosed TCs were analysed using Predictive Analytics Software (PASW) Statistics for Windows, Version 18 (Chicago: SPSS Inc.) and the results were expressed in descriptive statistics. RESULTS: Sixty one cases of TCs were identified in this study constituting 10.8% of thyroid biopsies received at our centre during the period under review. There were 51 (83.6%) females and 10 (16.4%) males giving a ratio of 5.1:1, and a mean age of 45.9 years. The commonest histologic type was Papillary Thyroid Carcinoma (PTC) (42.6%), followed by; follicular thyroid carcinoma (37.7%), medullary thyroid carcinoma (4.9%), anaplastic carcinomas (3.3%), Non-Hodgkin lymphoma (1.6%) and metastatic squamous cell carcinoma (3.3%). Mixed papillary/ follicular carcinoma (4.9%) and mixed papillary/ anaplastic carcinoma (1.6%) were also identified. CONCLUSION: TC continues to predominate amongst females, occurring mainly in early middle age group in Southeastern Nigeria. PTC is now the commonest histologic type.
