ABSTRACT
Morphological characteristics of bone tissues were studied in the feet of patients with diabetes mellitus type 1 and 2 (DM1 and DM2). Osteoblasts and osteoclasts prevalence, the presence of collagen type III in the composition of newly formed bone were characteristic for DM1. Osteocytes prevalence and abundant granulation tissue in newly formed bone was a feature of DM2. The analysis of bone tissue resorption suggests that lacunar osteoclastic resorpsion is the main type in DM1 while periosteocytic osteolysis and smooth resorption are typical for DM2. Thus, osteolysis genesis and synthesis of bone tissue in DM1 and DM2 may be different.
Subject(s)
Bone Resorption/pathology , Diabetes Mellitus, Type 1/pathology , Diabetes Mellitus, Type 2/pathology , Diabetic Foot/pathology , Foot Bones/pathology , Adult , Aged , Bone Resorption/etiology , Bone Resorption/metabolism , Collagen Type I/metabolism , Collagen Type II/metabolism , Diabetes Mellitus, Type 1/complications , Diabetes Mellitus, Type 1/metabolism , Diabetes Mellitus, Type 2/complications , Diabetes Mellitus, Type 2/metabolism , Diabetic Foot/complications , Diabetic Foot/metabolism , Female , Fibronectins/metabolism , Foot Bones/metabolism , Humans , Immunohistochemistry , Male , Middle Aged , Osteolysis/etiology , Osteolysis/metabolism , Osteolysis/pathology , SyndromeABSTRACT
The determination of the level of leukocytes and ESR in 25 patients was shown to be of low informative value in differential diagnostics of destructive injuries of feet in patients with diabetes mellitus. An analysis of the biochemical markers of the bone remodeling has demonstrated high informative value of this method in differential diagnostics of acute stage of diabetic osteoarthropathy and osteomyelitis that allows to use it in complex examinations of osteomyelitis suspects.
