Histological tissue classification with a novel statistical filter-based convolutional neural network.

Deep networks have been of considerable interest in literature and have enabled the solution of recent real-world applications. Due to filters that offer feature extraction, Convolutional Neural Network (CNN) is recognized as an accurate, efficient and trustworthy deep learning technique for the solution of image-based challenges. The high-performing CNNs are computationally demanding even if they produce good results in a variety of applications. This is because a large number of parameters limit their ability to be reused on central processing units with low performance. To address these limitations, we suggest a novel statistical filter-based CNN (HistStatCNN) for image classification. The convolution kernels of the designed CNN model were initialized by continuous statistical methods. The performance of the proposed filter initialization approach was evaluated on a novel histological dataset and various histopathological benchmark datasets. To prove the efficiency of statistical filters, three unique parameter sets and a mixed parameter set of statistical filters were applied to the designed CNN model for the classification task. According to the results, the accuracy of GoogleNet, ResNet18, ResNet50 and ResNet101 models were 85.56%, 85.24%, 83.59% and 83.79%, respectively. The accuracy was improved by 87.13% by HistStatCNN for the histological data classification task. Moreover, the performance of the proposed filter generation approach was proved by testing on various histopathological benchmark datasets, increasing average accuracy rates. Experimental results validate that the proposed statistical filters enhance the performance of the network with more simple CNN models.

Multi-Class brain normality and abnormality diagnosis using modified Faster R-CNN.

BACKGROUND AND OBJECTIVE: The detection and analysis of brain disorders through medical imaging techniques are extremely important to get treatment on time and sustain a healthy lifestyle. Disorders cause permanent brain damage and alleviate the lifespan. Moreover, the classification of large volumes of medical image data manually by medicine experts is tiring, time-consuming, and prone to errors. This study aims to diagnose brain normality and abnormalities using a novel ResNet50 modified Faster Regions with Convolutional Neural Network(R-CNN) model. The classification task is performed into multiple classes which are hemorrhage, hydrocephalus, and normal. The proposed model both determines the borders of the normal/abnormal parts and classifies them with the highest accuracy. METHODS: To provide a comprehensive performance analysis in the classification problem, Machine Learning(ML) and Deep Learning(DL) techniques were discussed. Artificial Neural Network(ANN), AdaBoost(AB), Decision Tree(DT), Logistic Regression(LR), Naive Bayes(NB), Random Forest(RF), and Support Vector Machine(SVM) were used as ML models. Besides, various Convolutional Neural Network(CNN) models and proposed ResNet50 modified Faster R-CNN model were used as DL models. Methods were validated using a novel brain dataset that contains both normal and abnormal images. RESULTS: Based on results, LR obtained the highest result among ML methods and DenseNet201 obtained the highest results among CNN models with the accuracy of 84.80% and 85.68% for the classification task, respectively. Besides, the accuracy obtained by the proposed model is 99.75%. CONCLUSIONS: Experimental results demonstrate that the proposed model has yielded better performance for detection and classification tasks. This artificial intelligence(AI) framework can be utilized as a computer-aided medical decision support system for medical experts.

A new method for automatic counting of ovarian follicles on whole slide histological images based on convolutional neural network.

The ovary is a complex endocrine organ that shows significant structural and functional changes in the female reproductive system over recurrent cycles. There are different types of follicles in the ovarian tissue. The reproductive potential of each individual depends on the numbers of these follicles. However, genetic mutations, toxins, and some specific drugs have an effect on follicles. To determine these effects, it is of great importance to count the follicles. The number of follicles in the ovary is usually counted manually by experts, which is a tedious, time-consuming and intense process. In some cases, the experts count the follicles in a subjective way due to their knowledge. In this study, for the first time, a method has been proposed for automatically counting the follicles of ovarian tissue. Our method primarily involves filter-based segmentation applied to whole slide histological images, based on a convolutional neural network (CNN). A new method is also proposed to eliminate the noise that occurs after the segmentation process and to determine the boundaries of the follicles. Finally, the follicles whose boundaries are determined are classified. To evaluate its performance, the results of the proposed method were compared with those obtained by two different experts and the results of the Faster R-CNN model. The number of follicles obtained by the proposed method was very close to the number of follicles counted by the experts. It was also found that the proposed method was much more successful than the Faster R-CNN model.

An improved marriage in honey bees optimization algorithm for single objective unconstrained optimization.

Marriage in honey bees optimization (MBO) is a metaheuristic optimization algorithm developed by inspiration of the mating and fertilization process of honey bees and is a kind of swarm intelligence optimizations. In this study we propose improved marriage in honey bees optimization (IMBO) by adding Levy flight algorithm for queen mating flight and neighboring for worker drone improving. The IMBO algorithm's performance and its success are tested on the well-known six unconstrained test functions and compared with other metaheuristic optimization algorithms.