Cooperative differentiation through clustering in multicellular populations.

The coordinated development of multicellular organisms is driven by intercellular communication. Differentiation into diverse cell types is usually associated with the existence of distinct attractors of gene regulatory networks, but how these attractors emerge from cell-cell coupling is still an open question. In order to understand and characterize the mechanisms through which coexisting attractors arise in multicellular systems, here we systematically investigate the dynamical behavior of a population of synthetic genetic oscillators coupled by chemical means. Using bifurcation analysis and numerical simulations, we identify various attractors and attempt to deduce from these findings a way to predict the organized collective behavior of growing populations. Our results show that dynamical clustering is a generic property of multicellular systems. We argue that such clustering might provide a basis for functional differentiation and variability in biological systems.

Noise-induced inhibitory suppression of frequency-selective stochastic resonance.

We study the control of oscillations in a system of inhibitory coupled noisy excitable and oscillatory units. Using dynamical properties of inhibition, we find regimes when the oscillations can be suppressed but the information signal of a certain frequency can be transmitted through the system. The mechanism of this phenomenon is a resonant interplay of noise and the transmission signal provided by certain value of inhibitory coupling. Analyzing a system of three or four oscillators representing neural clusters, we show that this suppression can be effectively controlled by coupling and noise amplitudes.

Stochastic multiresonance in the coupled relaxation oscillators.

We study the noise-dependent dynamics in a chain of four very stiff excitable oscillators of the FitzHugh-Nagumo type locally coupled by inhibitor diffusion. We could demonstrate frequency- and noise-selective signal acceptance which is based on several noise-supported stochastic attractors that arise owing to slow variable diffusion between identical excitable elements. The attractors have different average periods distinct from that of an isolated oscillator and various phase relations between the elements. We explain the correspondence between the noise-supported stochastic attractors and the observed resonance peaks in the curves for the linear response versus signal frequency.

Noise-induced excitability in oscillatory media.

A noise-induced phase transition to excitability is reported in oscillatory media with FitzHugh-Nagumo dynamics. This transition takes place via a noise-induced stabilization of a deterministically unstable fixed point of the local dynamics, while the overall phase-space structure of the system is maintained. Spatial coupling is required to prevent oscillations through suppression of fluctuations (via clustering in the case of local coupling). Thus, the joint action of coupling and noise leads to a different type of phase transition and results in a stabilization of the system. The resulting regime is shown to display characteristic traits of excitable media, such as stochastic resonance and wave propagation. This effect thus allows the transmission of signals through an otherwise globally oscillating medium.

Oscillatory amplification of stochastic resonance in excitable systems.

We study systems which combine both oscillatory and excitable properties, and hence intrinsically possess two internal frequencies, responsible for standard spiking and for small amplitude oscillatory limit cycles (Canard orbits). We show that in such a system the effect of stochastic resonance can be amplified by application of an additional high-frequency signal, which is in resonance with the oscillatory frequency. It is important that for this amplification one needs much lower noise intensities as for conventional stochastic resonance in excitable systems.

Doubly stochastic coherence via noise-induced symmetry in bistable neural models.

The generation of coherent dynamics due to noise in an activator-inhibitor system describing bistable neural dynamics is investigated. We show that coherence can be induced in deterministically asymmetric regimes via symmetry restoration by multiplicative noise, together with the action of additive noise which induces jumps between the two stable steady states. The phenomenon is thus doubly stochastic, because both noise sources are necessary. This effect can be understood analytically in the frame of a small-noise expansion and is confirmed experimentally in a nonlinear electronic circuit. Finally, we show that spatial coupling enhances this coherent behavior in a form of system-size coherence resonance.

Frequency-dependent stochastic resonance in inhibitory coupled excitable systems.

We study frequency selectivity in noise-induced subthreshold signal processing in a system with many noise-supported stochastic attractors which are created due to slow variable diffusion between identical excitable elements. Such a coupling provides coexisting of several average periods distinct from that of an isolated oscillator and several phase relations between elements. We show that the response of the coupled elements under different noise levels can be significantly enhanced or reduced by forcing some elements in resonance with these new frequencies which correspond to appropriate phase relations.