Lithium action upon Hep2 tumoral cells in vitro.

Previously performed light microscopy studies have demonstrated Hep2 tumoral cells to be sensitive to concentrations of LiCl 1 mM and 2 mM. At those concentrations, LiCl induces morphological alterations consisting in cell hypertrophy, formations of cells with several nuclei similar to syncytium, cytoplasmic projections. This study focuses on the action of LiCl on growth kinetics, cloning capacity and protein composition of Hep2 tumoral cells. We have found LiCl (1 mM and 2 mM) to influence all those parameters.