ABSTRACT
The aim of this study was to examine the efficacy and safety of autogenous partially demineralized dentin matrix (APDDM) prepared onsite, for clinical application in bone regeneration procedures related to implant dentistry, including socket preservation, alveolar ridge augmentation, and maxillary sinus floor augmentation. In this study, 16 patients underwent dental implant placement using APDDM transplantation. There were no systemic or local complications (including surgical site infection) in any of the cases, and oral rehabilitation using dental implants was successful in all cases for at least 2 years after attachment of the suprastructure. This report describes the clinical application of APDDM prepared immediately after tooth extraction to bone augmentation, taking advantage of the relatively short preparation time due to partial demineralization. APDDM, as introduced in this study, is an efficient, safe, and reasonable bone substitute. Consequently, this material has the potential to become one of the options as a bone substitute in implant dentistry.
Subject(s)
Alveolar Ridge Augmentation/methods , Dental Implants , Dentin , Immediate Dental Implant Loading , Adult , Bone Regeneration/drug effects , Female , Humans , Male , Middle Aged , Pilot Projects , Radiography, Panoramic , Tomography, X-Ray Computed , Tooth Extraction , Tooth Socket/surgery , Treatment OutcomeABSTRACT
Oral mucositis (ulcer) is a serious and painful side effect for patients with head and neck cancer following radiation therapy. However, current clinical strategies cannot efficiently prevent the occurrence of oral mucositis. In this study, we investigated whether bone marrow-derived cells (BMDCs) prevented the occurrence and/or decreased the severity of radiation-induced oral mucositis. Fresh concentrated BMDCs from male C3H mice were transplanted intravenously into female mice after tongue irradiation. For 14 days postirradiation, the changes of body weight and the time courses of ulceration were observed. Until the ulcer reached maximum size (7 days postirradiation), macroscopic and histologic analyses of harvested tongues were performed to detect the behavior of donor BMDCs. Between 2 and 5 days postirradiation, BMDCs-transplanted mice showed more expression of stem cell markers (c-Kit, Sca-1) and EGFR and fewer apoptotic cells when compared with nontransplanted control mice (irradiation group). On day 7, there were fewer and smaller ulcers observed in the BMDCs-transplanted group. Tongues of these mice had preserved their epithelial thickness, and regenerative activities (blood vessels formation, cell proliferation) were higher than they were in the irradiation group. Fluorescently labeled BMDCs were not detected in tongue epithelium but rather in connective tissue (dermis) just below the basal cell layer. These findings suggest that exogenous BMDCs behave to reduce radiogenic oral mucositis in a paracrine manner.
Subject(s)
Bone Marrow Transplantation/methods , Glossitis/therapy , Radiation Injuries/therapy , Tongue/radiation effects , Animals , Apoptosis/physiology , Basement Membrane/pathology , Basement Membrane/radiation effects , Disease Models, Animal , Epithelium/pathology , Epithelium/radiation effects , Female , Glossitis/etiology , Male , Mice , Mice, Inbred C3H , Neovascularization, Physiologic/physiology , Oral Ulcer/etiology , Oral Ulcer/therapy , Proliferating Cell Nuclear Antigen/analysis , Random Allocation , Re-Epithelialization/physiology , Regeneration/physiology , Tongue/pathologyABSTRACT
There have been few reports in the literature concerning the magnetic resonance imaging (MRI) appearances of fibrous dysplasia. We reviewed MRIs of 4 patients with craniofacial lesions. Using a 1.5-T Signa Unit (General Electric, Milwaukee, WI), both T1- and T2-weighted MRI scans were performed. In our 4 patients, the fibrous dysplastic lesions were characterized by a decreased signal on both T1- and T2-weighted images. And all lesions had sharply demarcated borders. The fine image of fibrous dysplasia by MRI is extremely useful, not only as a diagnostic aid, but also as an invaluable guide to surgery.
Subject(s)
Fibrous Dysplasia of Bone/diagnosis , Skull/pathology , Adolescent , Adult , Child , Facial Bones/pathology , Female , Humans , Magnetic Resonance Imaging , MaleABSTRACT
There have been few reports in the literature concerning the long-term prognosis of fibrous dysplasia. We reported here a boy with craniofacial fibrous dysplasia, which showed marked involution at the end of his puberty.
Subject(s)
Fibrous Dysplasia, Polyostotic/surgery , Maxillary Diseases/surgery , Orbital Diseases/surgery , Child , Fibrous Dysplasia, Polyostotic/diagnosis , Fibrous Dysplasia, Polyostotic/physiopathology , Humans , Male , Maxillary Diseases/diagnosis , Maxillary Diseases/physiopathology , Orbital Diseases/diagnosis , Orbital Diseases/physiopathology , Postoperative Period , Puberty , Technetium Tc 99m Medronate , Tomography, X-Ray ComputedABSTRACT
Among the routes of gaseous I transfer to rice grains, direct deposition to the hull of rice plants and the subsequent transfer to brown rice and polished rice should be more critical than leaf absorption-translocation. A grain number normalized deposition velocity (Vs) is recommended as a key parameter to assess the amount of gaseous I deposited on the rough rice. This parameter is given as "iodine content per unit number of grain per unit time" divided by "iodine concentration per unit volume of the air." After the heading period the surface area of rough rice is almost constant but weight increases with time. Therefore, mass normalized deposition velocity (VD) varies with time. By introducing Vs instead of VD, the variations could be converged into narrow ranges. The contribution of gaseous I from the atmosphere to rough rice, brown rice and polished rice were estimated using Vs values obtained experimentally and gaseous I concentration in the air.
