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Bioorg Med Chem Lett
; 12(9): 1275-8, 2002 May 06.
Article
in English
| MEDLINE
| ID: mdl-11965369
ABSTRACT
A novel non-peptidyl endothelin converting enzyme inhibitor was obtained through a pharmacophore analysis of known inhibitors and three-dimensional structure database search. Analogues of the new inhibitor were designed using the structure-activity relationship of known inhibitors and synthesized. In anesthetized rats, intraperitoneal administration of the analogues suppressed the pressor responses induced by big endothelin-1.