ABSTRACT
In this prospective cohort study, minocycline-ethylenediaminetetraacetate (M-EDTA) was used as a lock solution in indwelling ports inserted in 14 children with cancer. No port infections, thrombotic events, or other adverse events were observed, compared with 10 port infections that occurred in 48 control patients whose ports were flushed with heparin. M-EDTA is a promising lock solution in long-term catheters.
Subject(s)
Anti-Bacterial Agents/therapeutic use , Edetic Acid/therapeutic use , Minocycline/therapeutic use , Neoplasms/complications , Prosthesis-Related Infections/prevention & control , Thrombosis/prevention & control , Catheters, Indwelling , Chelating Agents/therapeutic use , Child , Child, Preschool , Cohort Studies , Drug Therapy, Combination , Female , Humans , Male , Prospective StudiesABSTRACT
To prevent nosocomial pulmonary aspergillosis during hospital construction, neutropenic patients with hematologic malignancy were required to wear high-efficiency masks when leaving their rooms. The rate of nosocomial aspergillosis decreased from 0.73 per 1,000 hospital patient-days during fiscal years 1993 to 1996 to 0.24 per 1,000 hospital patient-days during fiscal years 1996 to 1999 (P < .001). High-efficiency masks reduced nosocomial aspergillosis during hospital construction.
