[Enteral detoxication in patients with liver cirrhosis and bleeding from the esophageal and gastric varices ]. / Enteral'naia detoksikatsiia u bol'nykh tsirrozom pecheni i krovotecheniem iz varikozno-rasshirennykh ven pishchevoda i zheludka.

A new method of enteral detoxication with the use of both well-known medicines ("Normase", "Sorbit") and new medicine-"Rafinosa" is described. Clinical effectiveness (normalization of neurological status) of these medicines correlates with normalization of blood amino acids unbalance, decrease of the catabolic processes and accumulation of toxic products of nitrogenous metabolism. All the above medicines (Italian made "Normase", "Sorbit" and Russian made "Rafinosa") are equally important for clinical practice. Enternal detoxication may be effective only in case of preventing relapsing bleeding by all possible measures from endoscopic thrombosing and endovascular embolisation of varicose veins to direct surgical operation on the esophageal and cardial veins.

[Several factors in the pathogenesis of hepatic failure in patients with liver cirrhosis and bleeding from esophageal and gastric varicose veins]. / Izuchenie nekotorykh faktorov patogeneza pechenochnoi nedostatochnosti u bol'nykh tsirrozom pecheni i krovotecheniem iz varikozno-rasshirennykh ven pishchevoda i zheludka.

Bleeding in patients with liver cirrhosis leads to the activation of catabolic processes, accumulation of end products of nitrogen metabolism and pronounced imbalance of blood plasma amino acids. There is a correlation between the changes observed and disorders in neurological status. The authors hold that increased catabolism, pronounced imbalance of blood plasma amino acids and elevated blood ammonia level are the leading factors affecting the onset of hepatic encephalopathy.