Initial experience with an electron FLASH research extension (FLEX) for the Clinac system.

PURPOSE: Radiotherapy delivered at ultra-high-dose-rates (≥40 Gy/s), that is, FLASH, has the potential to effectively widen the therapeutic window and considerably improve the care of cancer patients. The underlying mechanism of the FLASH effect is not well understood, and commercial systems capable of delivering such dose rates are scarce. The purpose of this study was to perform the initial acceptance and commissioning tests of an electron FLASH research product for preclinical studies. METHODS: A linear accelerator (Clinac 23EX) was modified to include a non-clinical FLASH research extension (the Clinac-FLEX system) by Varian, a Siemens Healthineers company (Palo Alto, CA) capable of delivering a 16 MeV electron beam with FLASH and conventional dose rates. The acceptance, commissioning, and dosimetric characterization of the FLEX system was performed using radiochromic film, optically stimulated luminescent dosimeters, and a plane-parallel ionization chamber. A radiation survey was conducted for which the shielding of the pre-existing vault was deemed sufficient. RESULTS: The Clinac-FLEX system is capable of delivering a 16 MeV electron FLASH beam of approximately 1 Gy/pulse at isocenter and reached a maximum dose rate >3.8 Gy/pulse near the upper accessory mount on the linac gantry. The percent depth dose curves of the 16 MeV FLASH and conventional modes for the 10 × 10 cm2 applicator agreed within 0.5 mm at a range of 50% of the maximum dose. Their respective profiles agreed well in terms of flatness but deviated for field sizes >10 × 10 cm2 . The output stability of the FLASH system exhibited a dose deviation of <1%. Preliminary cell studies showed that the FLASH dose rate (180 Gy/s) had much less impact on the cell morphology of 76N breast normal cells compared to the non-FLASH dose rate (18 Gy/s), which induced large-size cells. CONCLUSION: Our studies characterized the non-clinical Clinac-FLEX system as a viable solution to conduct FLASH research that could substantially increase access to ultra-high-dose-rate capabilities for scientists.

Transverse oscillating bubble enhanced laser-driven betatron X-ray radiation generation.

Ultrafast high-brightness X-ray pulses have proven invaluable for a broad range of research. Such pulses are typically generated via synchrotron emission from relativistic electron bunches using large-scale facilities. Recently, significantly more compact X-ray sources based on laser-wakefield accelerated (LWFA) electron beams have been demonstrated. In particular, laser-driven sources, where the radiation is generated by transverse oscillations of electrons within the plasma accelerator structure (so-called betatron oscillations) can generate highly-brilliant ultrashort X-ray pulses using a comparably simple setup. Here, we experimentally demonstrate a method to markedly enhance the parameters of LWFA-driven betatron X-ray emission in a proof-of-principle experiment. We show a significant increase in the number of generated photons by specifically manipulating the amplitude of the betatron oscillations by using our novel Transverse Oscillating Bubble Enhanced Betatron Radiation scheme. We realize this through an orchestrated evolution of the temporal laser pulse shape and the accelerating plasma structure. This leads to controlled off-axis injection of electrons that perform large-amplitude collective transverse betatron oscillations, resulting in increased radiation emission. Our concept holds the promise for a method to optimize the X-ray parameters for specific applications, such as time-resolved investigations with spatial and temporal atomic resolution or advanced high-resolution imaging modalities, and the generation of X-ray beams with even higher peak and average brightness.

Transient Relativistic Plasma Grating to Tailor High-Power Laser Fields, Wakefield Plasma Waves, and Electron Injection.

We show the first experiment of a transverse laser interference for electron injection into the laser plasma accelerators. Simulations show such an injection is different from previous methods, as electrons are trapped into later acceleration buckets other than the leading ones. With optimal plasma tapering, the dephasing limit of such unprecedented electron beams could be potentially increased by an order of magnitude. In simulations, the interference drives a relativistic plasma grating, which triggers the splitting of relativistic-intensity laser pulses and wakefield. Consequently, spatially dual electron beams are accelerated, as also confirmed by the experiment.

Electron Trapping from Interactions between Laser-Driven Relativistic Plasma Waves.

Interactions of large-amplitude relativistic plasma waves were investigated experimentally by propagating two synchronized ultraintense femtosecond laser pulses in plasma at oblique crossing angles to each other. The electrostatic and electromagnetic fields of the colliding waves acted to preaccelerate and trap electrons via previously predicted, but untested injection mechanisms of ponderomotive drift and wake-wake interference. High-quality energetic electron beams were produced, also revealing valuable new information about plasma-wave dynamics.

Wavefront-correction for nearly diffraction-limited focusing of dual-color laser beams to high intensities.

We demonstrate wavefront correction of terawatt-peak-power laser beams at two distinct and well-separated wavelengths. Simultaneous near diffraction-limited focusability is achieved for both the fundamental (800 nm) and second harmonic (400 nm) of Ti:sapphire-amplified laser light. By comparing the relative effectiveness of various correction loops, the optimal ones are found. Simultaneous correction of both beams of different color relies on the linear proportionality between their wavefront aberrations. This method can enable two-color experiments at relativistic intensities.

Generation of 9 MeV γ-rays by all-laser-driven Compton scattering with second-harmonic laser light.

Gamma-ray photons with energy >9 MeV were produced when second-harmonic-generated laser light (3 eV) inverse-Compton-scattered from a counterpropagating relativistic (~450 MeV) laser-wakefield-accelerated electron beam. Two laser pulses from the same laser system were used: one to accelerate electrons and one to scatter. Since the two pulses play very different roles in the γ-ray generation process, and thus have different requirements, a novel laser system was developed. It separately and independently optimized the optical properties of the two pulses. This approach also mitigated the deleterious effects on beam focusing that generally accompany nonlinear optics at high peak-power levels.

Adaptive-feedback spectral-phase control for interactions with transform-limited ultrashort high-power laser pulses.

Fourier-transform-limited light pulses were obtained at the laser-plasma interaction point of a 100-TW peak-power laser in vacuum. The spectral-phase distortion induced by the dispersion mismatching between the stretcher, compressor, and dispersive materials was fully compensated for by means of an adaptive closed-loop. The coherent temporal contrast on the sub-picosecond time scale was two orders of magnitude higher than that without adaptive control. This novel phase control capability enabled the experimental study of the dependence of laser wakefield acceleration on the spectral phase of intense laser light.

Analytical solutions for the electromagnetic fields of tightly focused laser beams of arbitrary pulse length.

The analytical solution for a monochromatic focused laser beam was recently published [Opt. Lett.31, 1447 (2006)]. The effect of introducing bandwidth by including a finite-length temporal pulse envelope is included exactly. This is done formally first in the frequency domain for an arbitrary pulse shape, and the specific case of a cosine-squared envelope is then solved analytically for all pulse lengths, thereby decreasing the computation time by 2 orders of magnitude. The inclusion of longer wavelengths reduces the fraction of laser energy in the focus from 86.5% to 83.5% for a 5 fs Ti:sapphire laser and 72.7% in a single-cycle pulse.

Exact analytical solution for the vector electromagnetic field of Gaussian, flattened Gaussian, and annular Gaussian laser modes.

The exact vector integral solution for all the electromagnetic field components of a general flattened Gaussian laser mode is derived by using the angular spectrum method. This solution includes the pure and annular Gaussian modes as special cases. The integrals are of the form of Gegenbauer's finite integral and are computed analytically for each case, yielding fields satisfying the Maxwell equations exactly in the form of quickly converging Fourier-Gegenbauer series.

Thomson scattering and ponderomotive intermodulation within standing laser beat waves in plasma.

Electrons in a standing electromagnetic wave--an optical lattice--tend to oscillate due to the quiver and ponderomotive potentials. For sufficiently intense laser fields (Ilamda2 approximately < or = 5 x 10(17) W cm(-2) microm2) and in plasmas with sufficiently low electron densities (n approximately < or = 10(18) cm(-3)), these oscillations can occur faster than the plasma can respond. This paper shows that these oscillations result in Thomson scattering of light at both the laser and ponderomotive bounce frequencies and their harmonics as well as at mixtures of these frequencies. We term this mixing ponderomotive intermodulation. Here, the case of counterpropagating laser beams creating a one-dimensional (1D) optical lattice is analyzed. The near-equilibrium electron orbits and subsequent Thomson scattering patterns are computed in the single-particle limit. Scaling laws are derived to quantify the range of validity of this approach. Finally, collective plasma and laser focusing effects are included by using particle-in-cell (PIC) techniques. This effect resulting in light-frequency conversion has applications both as an infrared light source and as a means to diagnose high laser intensities inside dense plasmas.

Optical deflection and temporal characterization of an ultrafast laser-produced electron beam.

The interaction of a laser-produced electron beam with an ultraintense laser pulse in free space is studied. We show that the optical pulse with a(0)=0.5 imparts momentum to the electron beam, causing it to deflect along the laser propagation direction. The observed 3-degree angular deflection is found to be independent of polarization and in good agreement with a theoretical model for the interaction of free electrons with a tightly focused Gaussian pulse, but only when longitudinal fields are taken into account. This technique is used to temporally characterize a subpicosecond laser-wakefield-driven electron bunch. Applications to electron-beam conditioning are also discussed.

Production of a keV x-ray beam from synchrotron radiation in relativistic laser-plasma interaction.

We demonstrate that a beam of x-ray radiation can be generated by simply focusing a single high-intensity laser pulse into a gas jet. A millimeter-scale laser-produced plasma creates, accelerates, and wiggles an ultrashort and relativistic electron bunch. As they propagate in the ion channel produced in the wake of the laser pulse, the accelerated electrons undergo betatron oscillations, generating a femtosecond pulse of synchrotron radiation, which has keV energy and lies within a narrow (50 mrad) cone angle.

Backscattering of an intense laser beam by an electron.

We present a novel, simple asymptotic expansion for the spectrum of radiation that is backscattered from a laser by a counterpropagating (or copropagating) electron. The solutions are presented in such a way that they explicitly show the relative merit of using an intense laser and of an energetic electron beam in x-ray production in the single particle regime. Simple scaling laws are given.