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1.
Gen Hosp Psychiatry ; 60: 65-75, 2019.
Article in English | MEDLINE | ID: mdl-31349204

ABSTRACT

OBJECTIVE: Evidence-based therapies for posttraumatic stress disorder are underutilized and at times unavailable in specialty settings. We reviewed the literature on interventions to treat PTSD within primary care to make recommendations on their effectiveness as treatment modalities or ways to improve engagement in specialty care. METHOD: We searched PubMed, PsychInfo, CINHAL, and Cochrane Reviews databases using search terms related to PTSD and primary care. We excluded clinical guidelines and studies of screening only or subthreshold PTSD. RESULTS: 524 articles were identified. Twenty-one papers on 15 interventions met review criteria. Seven interventions focus on individual therapies studied via small feasibility studies to prepare for full-scale intervention research. Eight describe treatment programs in primary care based on collaborative care that included medication management, tracking outcomes, referral services, and for some psychotherapy (versus psychotherapy referral). Ten interventions were feasibility studies which precludes meaningful comparison of effect sizes. Of the four RCTs of treatment programs, only two including some psychotherapy found improvements in PTSD symptoms. CONCLUSION: More research is needed to adapt treatment for PTSD to primary care. Collaborative care may be a promising framework for improving the reach of PTSD treatments when psychotherapy is offered within the collaborative care team.


Subject(s)
Cognitive Behavioral Therapy , Feasibility Studies , Mental Health Services , Primary Health Care , Randomized Controlled Trials as Topic , Stress Disorders, Post-Traumatic/therapy , Cognitive Behavioral Therapy/statistics & numerical data , Humans , Mental Health Services/statistics & numerical data , Primary Health Care/statistics & numerical data , Randomized Controlled Trials as Topic/statistics & numerical data
2.
Contemp Clin Trials ; 60: 113-124, 2017 09.
Article in English | MEDLINE | ID: mdl-28642211

ABSTRACT

INTRODUCTION: Depression and diabetes are highly prevalent worldwide and often co-exist, worsening outcomes for each condition. Barriers to diagnosis and treatment are exacerbated in low and middle-income countries with limited health infrastructure and access to mental health treatment. The INtegrating DEPrEssioN and Diabetes treatmENT (INDEPENDENT) study tests the sustained effectiveness and cost-effectiveness of a multi-component care model for individuals with poorly-controlled diabetes and depression in diabetes clinics in India. MATERIALS AND METHODS: Adults with diabetes, depressive symptoms (Patient Health Questionnaire-9 score≥10), and ≥1 poorly-controlled cardiometabolic indicator (either HbA1c≥8.0%, SBP≥140mmHg, and/or LDL≥130mg/dl) were enrolled and randomized to the intervention or usual care. The intervention combined collaborative care, decision-support, and population health management. The primary outcome is the between-arm difference in the proportion of participants achieving combined depression response (≥50% reduction in Symptom Checklist score from baseline) AND one or more of: ≥0.5% reduction in HbA1c, ≥5mmHg reduction in SBP, or ≥10mg/dl reduction in LDL-c at 24months (12-month intervention; 12-month observational follow-up). Other outcomes include control of individual parameters, patient-centered measures (i.e. treatment satisfaction), and cost-effectiveness. RESULTS: The study trained seven care coordinators. Participant recruitment is complete - 940 adults were screened, with 483 eligible, and 404 randomized (196 to intervention; 208 to usual care). Randomization was balanced across clinic sites. CONCLUSIONS: The INDEPENDENT model aims to increase access to mental health care and improve depression and cardiometabolic disease outcomes among complex patients with diabetes by leveraging the care provided in diabetes clinics in India (clinicaltrials.gov number: NCT02022111).


Subject(s)
Case Management/organization & administration , Depression/epidemiology , Depression/therapy , Diabetes Mellitus, Type 2/epidemiology , Diabetes Mellitus, Type 2/therapy , Self Care/methods , Adult , Aged , Blood Pressure , Case Management/economics , Cholesterol, LDL/blood , Cost-Benefit Analysis , Female , Glycated Hemoglobin , Humans , India , Male , Middle Aged , Motivational Interviewing/methods , Patient Education as Topic/methods , Research Design , Single-Blind Method
3.
Psychosomatics ; 42(5): 391-6, 2001.
Article in English | MEDLINE | ID: mdl-11739905

ABSTRACT

This study assesses the levels of depression, anxiety, and delirium during admission to three adult critical care units (CCU) and the performance of CCU staff with respect to detection and treatment. During a 1-month period, 96 consecutive patients were evaluated on the first day of admission by an independent rater, using the Hospital Anxiety Depression Scale and the Confusional Assessment Method. Frequency of alcohol use and demographic data were recorded. CCU teams rarely made diagnoses of anxiety, depression, or delirium. On at least one screening test, 29.2% of patients were positive. Delirium was present in 7.3%, depression in 13.7%, anxiety in 24%, and possible problem drinking in 37.9%. Although some form of psychiatric treatment was offered to 58%, there was low agreement between psychiatric diagnoses made by the independent rater and the diagnoses made and treatments used by CCU staff. This suggests that the CCU staff are using psychotropic medications without any clear documentation and perhaps clear understanding of the psychiatric diagnoses they are treating. In summary, we found high rates of psychiatric disorders in adult CCU patients but low rates of detection and only moderate rates of treatment by CCU staff.


Subject(s)
Anxiety/diagnosis , Anxiety/drug therapy , Critical Care/standards , Delirium/diagnosis , Delirium/drug therapy , Depression/diagnosis , Depression/drug therapy , Intensive Care Units/standards , Adolescent , Adult , Aged , Aged, 80 and over , Alcoholism/diagnosis , Anxiety/epidemiology , Colombia/epidemiology , Delirium/epidemiology , Depression/epidemiology , Drug Utilization/statistics & numerical data , Female , Humans , Intensive Care Units/statistics & numerical data , Male , Middle Aged , Prevalence , Prospective Studies , Psychotropic Drugs/therapeutic use
4.
Arch Gen Psychiatry ; 58(10): 935-42, 2001 Oct.
Article in English | MEDLINE | ID: mdl-11576031

ABSTRACT

BACKGROUND: Significant underuse of evidence-based treatments for depression persists in primary care. We examined the effects of 2 primary care-based quality improvement (QI) programs on medication management for depression. METHODS: A total of 1356 patients with depressive symptoms (60% with depressive disorders and 40% with subthreshold depression) from 46 primary care practices in 6 nonacademic managed care organizations were enrolled in a randomized controlled trial of QI for depression. Clinics were randomized to usual care or to 1 of 2 QI programs that involved training of local experts who worked with patients' regular primary care providers (physicians and nurse practitioners) to improve care for depression. In the QI-medications program, depression nurse specialists provided patient education and assessment and followed up patients taking antidepressants for up to 12 months. In the QI-therapy program, depression nurse specialists provided patient education, assessment, and referral to study-trained psychotherapists. RESULTS: Participants enrolled in both QI programs had significantly higher rates of antidepressant use than those in the usual care group during the initial 6 months of the study (52% in the QI-medications group, 40% in the QI-therapy group, and 33% in the usual care group). Patients in the QI-medications group had higher rates of antidepressant use and a reduction in long-term use of minor tranquilizers for up to 2 years, compared with patients in the QI-therapy or usual care group. CONCLUSIONS: Quality improvement programs for depression in which mental health specialists collaborate with primary care providers can substantially increase rates of antidepressant treatment. Active follow-up by a depression nurse specialist in the QI-medications program was associated with longer-term increases in antidepressant use than in the QI model without such follow-up.


Subject(s)
Antidepressive Agents/therapeutic use , Depressive Disorder/drug therapy , Evidence-Based Medicine/methods , Primary Health Care/standards , Quality Assurance, Health Care/methods , Adult , Anti-Anxiety Agents/therapeutic use , Depressive Disorder/therapy , Female , Follow-Up Studies , Humans , Logistic Models , Male , Managed Care Programs/organization & administration , Managed Care Programs/standards , Nurse Practitioners/statistics & numerical data , Patient Education as Topic , Physicians, Family/statistics & numerical data , Practice Guidelines as Topic , Primary Health Care/methods , Psychotherapy/methods , Psychotherapy/standards , Secondary Prevention , Treatment Outcome , Workforce
5.
Am J Psychiatry ; 158(10): 1638-44, 2001 Oct.
Article in English | MEDLINE | ID: mdl-11578996

ABSTRACT

OBJECTIVE: The authors evaluated the incremental cost-effectiveness of stepped collaborative care for patients with persistent depressive symptoms after usual primary care management. METHOD: Primary care patients initiating antidepressant treatment completed a standardized telephone assessment 6-8 weeks after the initial prescription. Those with persistent major depression or significant subthreshold depressive symptoms were randomly assigned to continued usual care or collaborative care. The collaborative care included systematic patient education, an initial visit with a consulting psychiatrist, 2-4 months of shared care by the psychiatrist and primary care physician, and monitoring of follow-up visits and adherence to medication regimen. Clinical outcomes were assessed through blinded telephone assessments at 1, 3, and 6 months. Health services utilization and costs were assessed through health plan claims and accounting data. RESULTS: Patients receiving collaborative care experienced a mean of 16.7 additional depression-free days over 6 months. The mean incremental cost of depression treatment in this program was $357. The additional cost was attributable to greater expenditures for antidepressant prescriptions and outpatient visits. No offsetting decrease in use of other health services was observed. The incremental cost-effectiveness was $21.44 per depression-free day. CONCLUSIONS: A stepped collaborative care program for depressed primary care patients led to substantial increases in treatment effectiveness and moderate increases in costs. These findings are consistent with those of other randomized trials. Improving outcomes of depression treatment in primary care requires investment of additional resources, but the return on this investment is comparable to that of many other widely accepted medical interventions.


Subject(s)
Continuity of Patient Care/economics , Depressive Disorder/therapy , Managed Care Programs/economics , Primary Health Care/methods , Adult , Ambulatory Care/economics , Ambulatory Care/statistics & numerical data , Antidepressive Agents/therapeutic use , Continuity of Patient Care/organization & administration , Cost-Benefit Analysis , Depressive Disorder/drug therapy , Depressive Disorder/economics , Female , Follow-Up Studies , Health Care Costs/statistics & numerical data , Health Maintenance Organizations/economics , Health Maintenance Organizations/organization & administration , Health Services/economics , Health Services/statistics & numerical data , Humans , Male , Managed Care Programs/organization & administration , Patient Care Team , Patient Compliance , Patient Education as Topic , Primary Health Care/economics , Psychiatry/economics , Psychiatry/methods , Referral and Consultation , Treatment Outcome
6.
Med Care ; 39(11): 1246-59, 2001 Nov.
Article in English | MEDLINE | ID: mdl-11606878

ABSTRACT

BACKGROUND: Utility methods that are responsive to changes in desirable outcomes are needed for cost-effectiveness (CE) analyses and to help in decisions about resource allocation. OBJECTIVES: Evaluated is the responsiveness of different methods that assign utility weights to subsets of SF-36 items to average improvements in health resulting from quality improvement (QI) interventions for depression. DESIGN: A group level, randomized, control trial in 46 primary care clinics in six managed care organizations. Clinics were randomized to one of two QI interventions or usual care. SUBJECTS: One thousand one hundred thirty-six patients with current depressive symptoms and either 12-month, lifetime, or no depressive disorder identified through screening 27,332 consecutive patients. MEASURES: Utility weighted SF-12 or SF-36 measures, probable depression, and physical and mental health-related quality of life scores. RESULTS: Several utility-weighted measures showed increases in utility values for patients in one of the interventions, relative to usual care, that paralleled the improved health effects for depression and emotional well being. However, QALY gains were small. Directly elicited utility values showed a paradoxical result of lower utility during the first year of the study for intervention patients relative to controls. CONCLUSIONS: The results raise concerns about the use of direct single-item utility measures or utility measures derived from generic health status measures in effectiveness studies for depression. Choice of measure may lead to different conclusions about the benefit and CE of treatment. Utility measures that capture the mental health and non-health outcomes associated with treatment for depression are needed.


Subject(s)
Depression/therapy , Depressive Disorder/therapy , Outcome Assessment, Health Care/economics , Quality Indicators, Health Care , Quality-Adjusted Life Years , Adult , Cost-Benefit Analysis , Depression/economics , Depressive Disorder/economics , Female , Follow-Up Studies , Health Status , Humans , Male , Middle Aged , Models, Econometric , Regression Analysis , Statistics, Nonparametric
7.
Psychiatr Serv ; 52(9): 1251-3, 2001 Sep.
Article in English | MEDLINE | ID: mdl-11533403

ABSTRACT

This study determined the frequency of problematic substance use and of counseling about drug and alcohol use among 867 women and 320 men who reported symptoms of depression in managed primary care clinics. Seventy-two (8.3 percent) of the women and 61 (19 percent) of the men reported hazardous drinking; 228 (26.3 percent) of the women and 94 (29.4 percent) of the men reported problematic drug use, including use of illicit drugs and misuse of prescription drugs. Only 17 (13.9 percent) of the patients who reported hazardous drinking and 18 (6.6 percent) of those who reported problematic drug use received counseling about drug or alcohol use during their last primary care visit. Men were significantly more likely than women to have received counseling about drug or alcohol use from their primary care practitioner.


Subject(s)
Depressive Disorder/complications , Practice Patterns, Physicians' , Primary Health Care , Substance-Related Disorders/epidemiology , Substance-Related Disorders/prevention & control , Adolescent , Adult , Aged , Aged, 80 and over , Alcoholism/epidemiology , Counseling , Female , Humans , Logistic Models , Male , Middle Aged , Sex Factors , United States/epidemiology
8.
JAMA ; 286(11): 1325-30, 2001 Sep 19.
Article in English | MEDLINE | ID: mdl-11560537

ABSTRACT

CONTEXT: Depression is a leading cause of disability worldwide, but treatment rates in primary care are low. OBJECTIVE: To determine the cost-effectiveness from a societal perspective of 2 quality improvement (QI) interventions to improve treatment of depression in primary care and their effects on patient employment. DESIGN: Group-level randomized controlled trial conducted June 1996 to July 1999. SETTING: Forty-six primary care clinics in 6 community-based managed care organizations. PARTICIPANTS: One hundred eighty-one primary care clinicians and 1356 patients with positive screening results for current depression. INTERVENTIONS: Matched practices were randomly assigned to provide usual care (n = 443 patients) or to 1 of 2 QI interventions offering training to practice leaders and nurses, enhanced educational and assessment resources, and either nurses for medication follow-up (QI-meds; n = 424 patients) or trained local psychotherapists (QI-therapy; n = 489). Practices could flexibly implement the interventions, which did not assign type of treatment. MAIN OUTCOME MEASURES: Total health care costs, costs per quality-adjusted life-year (QALY), days with depression burden, and employment over 24 months, compared between usual care and the 2 interventions. RESULTS: Relative to usual care, average health care costs increased $419 (11%) in QI-meds (P =.35) and $485 (13%) in QI-therapy (P =.28); estimated costs per QALY gained were between $15 331 and $36 467 for QI-meds and $9478 and $21 478 for QI-therapy; and patients had 25 (P =.19) and 47 (P =.01) fewer days with depression burden and were employed 17.9 (P =.07) and 20.9 (P =.03) more days during the study period. CONCLUSIONS: Societal cost-effectiveness of practice-initiated QI efforts for depression is comparable with that of accepted medical interventions. The intervention effects on employment may be of particular interest to employers and other stakeholders.


Subject(s)
Depressive Disorder/economics , Depressive Disorder/therapy , Family Practice/economics , Family Practice/standards , Managed Care Programs/standards , Mental Health Services/standards , Primary Health Care/standards , Quality Assurance, Health Care/economics , Cost of Illness , Cost-Benefit Analysis , Employment , Health Care Costs/statistics & numerical data , Health Services Research/methods , Humans , Managed Care Programs/economics , Mental Health Services/economics , Outcome and Process Assessment, Health Care , Primary Health Care/economics , Quality-Adjusted Life Years , United States
10.
Med Care ; 39(9): 934-44, 2001 Sep.
Article in English | MEDLINE | ID: mdl-11502951

ABSTRACT

BACKGROUND: Depression is common in primary care, but rates of adequate care are low. Little is known about the role of patient treatment preferences in encouraging entry into care. OBJECTIVES: To examine whether a primary care based depression quality improvement (QI) intervention designed to accommodate patient and provider treatment choice increases the likelihood that patients enter depression treatment and receive preferred treatment. METHODS: In 46 primary care clinics, patients with current depressive symptoms and either lifetime or current depressive disorder were identified through screening. Treatment preferences, patient characteristics, and use of depression treatments were assessed at baseline and 6 months by patient self-report. Matched clinics were randomized to usual care (UC) or 1 of 2 QI interventions. Data were analyzed using logistic regression models. RESULTS: For patients not in care at baseline, the QI interventions increased rates of entry into depression treatment compared with usual care (adjusted percentage: 50.0% +/- 5.3 and 33.0% +/- 4.9 for interventions vs. 15.9% +/- 3.6 for usual care; F = 12.973, P <0.0001). Patients in intervention clinics were more likely to get treatments they preferred compared with those in usual care (adjusted percentage: 54.2% +/- 3.3 and 50.7% +/- 3.1 for interventions vs. 40.5% +/- 3.1 for usual care; F = 6.034, P <0.003); however, in all clinics less than half of patients preferring counseling reported receiving it. CONCLUSIONS: QI interventions that support patient choice can improve the likelihood of patients receiving preferred treatments. Patient treatment preference appears to be related to likelihood of entering depression treatment, and patients preferring counseling may require additional interventions to enhance entry into treatment.


Subject(s)
Depressive Disorder/therapy , Mental Health Services/standards , Outcome and Process Assessment, Health Care , Patient Satisfaction/statistics & numerical data , Primary Health Care/standards , Total Quality Management , Adult , Antidepressive Agents/therapeutic use , Counseling/statistics & numerical data , Delivery of Health Care/organization & administration , Delivery of Health Care/standards , Depressive Disorder/nursing , Humans , Logistic Models , Male , Mental Health Services/organization & administration , Middle Aged , United States
11.
Arch Gen Psychiatry ; 58(7): 696-703, 2001 Jul.
Article in English | MEDLINE | ID: mdl-11448378

ABSTRACT

BACKGROUND: This article addresses whether dissemination of short-term quality improvement (QI) interventions for depression to primary care practices improves patients' clinical outcomes and health-related quality of life (HRQOL) over 2 years, relative to usual care (UC). METHODS: The sample included 1299 patients with current depressive symptoms and 12-month, lifetime, or no depressive disorder from 46 primary care practices in 6 managed care organizations. Clinics were randomized to UC or 1 of 2 QI programs that included training local experts and nurse specialists to provide clinician and patient education, assessment, and treatment planning, plus either nurse care managers for medication follow-up (QI-meds) or access to trained psychotherapists (QI-therapy). Outcomes were assessed every 6 months for 2 years. RESULTS: For most outcomes, differences between intervention and UC patients were not sustained for the full 2 years. However, QI-therapy reduced overall poor outcomes compared with UC by about 8 percentage points throughout 2 years, and by 10 percentage points compared with QI-meds at 24 months. Both interventions improved patients' clinical and role outcomes, relative to UC, over 12 months (eg, a 10-11 and 6-7 percentage point difference in probable depression at 6 and 12 months, respectively). CONCLUSIONS: While most outcome improvements were not sustained over the full 2 study years, findings suggest that flexible dissemination of short-term, QI programs in managed primary care can improve patient outcomes well after program termination. Models that support integrated psychotherapy and medication-based treatment strategies in primary care have the potential for relatively long-term patient benefits.


Subject(s)
Depressive Disorder/therapy , Primary Health Care/organization & administration , Adult , Antidepressive Agents/therapeutic use , Cognitive Behavioral Therapy , Female , Health Status , Humans , Male , Outcome Assessment, Health Care , Patient Care Planning , Patient Care Team , Primary Health Care/methods , Psychotherapy/methods , Quality of Life
12.
Med Care ; 39(8): 785-99, 2001 Aug.
Article in English | MEDLINE | ID: mdl-11468498

ABSTRACT

BACKGROUND: Late life depression can be successfully treated with antidepressant medications or psychotherapy, but few depressed older adults receive effective treatment. RESEARCH DESIGN: A randomized controlled trial of a disease management program for late life depression. SUBJECTS: Approximately 1,750 older adults with major depression or dysthymia are recruited from seven national study sites. INTERVENTION: Half of the subjects are randomly assigned to a collaborative care program where a depression clinical specialist supervised by a psychiatrist and a primary care expert supports the patient's regular primary care provider to treat depression. Intervention services are provided for 12 months using antidepressant medications and Problem Solving Treatment in Primary Care according to a stepped care protocol that varies intervention intensity according to clinical needs. The other half of the subjects are assigned to care as usual. EVALUATION: Subjects are independently assessed at baseline, 3 months, 6 months, 12 months, 18 months, and 24 months. The evaluation assesses the incremental cost-effectiveness of the intervention compared with care as usual. Specific outcomes examined include care for depression, depressive symptoms, health-related quality of life, satisfaction with depression care, health care costs, patient time costs, market and nonmarket productivity, and household income. CONCLUSIONS: The study blends methods from health services and clinical research in an effort to protect internal validity while maximizing the generalizability of results to diverse health care systems. We hope that this study will show the cost-effectiveness of a new model of care for late life depression that can be applied in a range of primary care settings.


Subject(s)
Depressive Disorder/therapy , Disease Management , Health Services for the Aged/standards , Primary Health Care/standards , Aged , Antidepressive Agents/therapeutic use , Cost-Benefit Analysis , Dysthymic Disorder/therapy , Female , Health Services for the Aged/economics , Humans , Inservice Training , Male , Outcome Assessment, Health Care , Patient Care Team , Patient Education as Topic , Primary Health Care/economics , Software Design , United States
14.
J Fam Pract ; 50(6): E1, 2001 Jun.
Article in English | MEDLINE | ID: mdl-11401751

ABSTRACT

Potential solutions for barriers to improved organization of care of depressive illness were identified. These included (1) aligning efforts to improve depression care with broader strategies for improving care of other chronic conditions; (2) increasing the availability of depression case management services in primary care; (3) developing registries and reminder systems to ensure active follow-up of depressed patients; (4) achieving agreement on how depression outcomes should be measured to provide outcomes-based performance standards; (5) providing greater support from mental health specialists for management of depressed patients by primary care providers; (6) campaigns to reduce the stigma associated with treatment of depressive illness; (7) increased dissemination of interventions that activate and empower patients managing a depressive illness; (8) redefining the lack of time of primary care providers for high-quality depression care as issues in organization of care and provider training; and (9) development of incentives (organizational or financial) for high-quality depression care. Research needs were identified according to what has been learned to date. Identified research needs included: studies of approaches to organization of case management, research in new populations (e.g., new diagnostic groups, rural populations, the disadvantaged, the elderly, and those with chronic medical illnesses), research on stepped care and relapse prevention strategies, evaluation of the societal benefits of improved depression care, and multisite trials and meta-analytic approaches that can provide adequate statistical power to assess societal benefits of improved care.


Subject(s)
Depressive Disorder/diagnosis , Depressive Disorder/therapy , Family Practice/standards , Health Services Accessibility/standards , Needs Assessment/organization & administration , Primary Health Care/standards , Research/standards , Total Quality Management/organization & administration , Case Management/organization & administration , Cost of Illness , Disease Management , Humans , Outcome Assessment, Health Care/organization & administration , Practice Guidelines as Topic , Quality of Health Care , Recurrence
15.
Arch Gen Psychiatry ; 58(3): 241-7, 2001 Mar.
Article in English | MEDLINE | ID: mdl-11231831

ABSTRACT

BACKGROUND: Despite high rates of relapse and recurrence, few primary care patients with recurrent or chronic depression are receiving continuation and maintenance-phase treatment. We hypothesized that a relapse prevention intervention would improve adherence to antidepressant medication and improve depression outcomes in high-risk patients compared with usual primary care. METHODS: Three hundred eighty-six patients with recurrent major depression or dysthymia who had largely recovered after 8 weeks of antidepressant treatment by their primary care physicians were randomized to a relapse prevention program (n = 194) or usual primary care (n = 192). Patients in the intervention group received 2 primary care visits with a depression specialist and 3 telephone visits over a 1-year period aimed at enhancing adherence to antidepressant medication, recognition of prodromal symptoms, monitoring of symptoms, and development of a written relapse prevention plan. Follow-up assessments were completed at 3, 6, 9, and 12 months by a telephone survey team blinded to randomization status. RESULTS: Those in the intervention group had significantly greater adherence to adequate dosage of antidepressant medication for 90 days or more within the first and second 6-month periods and were significantly more likely to refill medication prescriptions during the 12-month follow-up compared with usual care controls. Intervention patients had significantly fewer depressive symptoms, but not fewer episodes of relapse/recurrence over the 12-month follow-up period. CONCLUSIONS: A relapse prevention program targeted to primary care patients with a high risk of relapse/recurrence who had largely recovered after antidepressant treatment significantly improved antidepressant adherence and depressive symptom outcomes.


Subject(s)
Antidepressive Agents/therapeutic use , Depressive Disorder/drug therapy , Depressive Disorder/prevention & control , Primary Health Care , Adolescent , Adult , Aged , Antidepressive Agents/administration & dosage , Depressive Disorder/diagnosis , Drug Administration Schedule , Drug Prescriptions/statistics & numerical data , Female , Health Maintenance Organizations/statistics & numerical data , Humans , Male , Middle Aged , Patient Compliance , Patient Education as Topic , Phenylketonurias , Primary Health Care/statistics & numerical data , Secondary Prevention , Severity of Illness Index , Treatment Outcome
16.
J Gen Intern Med ; 15(12): 859-67, 2000 Dec.
Article in English | MEDLINE | ID: mdl-11119182

ABSTRACT

OBJECTIVE: Previous treatment trials have found that approximately one third of depressed patients have persistent symptoms. We examined whether depression severity, comorbid psychiatric illness, and personality factors might play a role in this lack of response. DESIGN: Randomized trial of a stepped collaborative care intervention versus usual care. SETTING: HMO in Seattle, Wash. PATIENTS: Patients with major depression were stratified into severe (N = 149) and mild to moderate depression (N = 79) groups prior to randomization. INTERVENTIONS: A multifaceted intervention targeting patient, physician, and process of care, using collaborative management by a psychiatrist and primary care physician. MEASUREMENTS AND MAIN RESULTS: Patients with more severe depression had a higher risk for panic disorder (odds ratio [OR], 5.8), loneliness (OR, 2.6), and childhood emotional abuse (OR, 2.1). Among those with less severe depression, intervention patients showed significantly improved depression outcomes over time compared with those in usual care (z = -3.06, P<.002); however, this difference was not present in the more severely depressed groups (z = 0.61, NS). Although the group with severe depression showed differences between the intervention and control groups from baseline to 3 months that were similar to the group with less severe depression (during the acute phase of the intervention), these differences disappeared by 6 months. CONCLUSIONS: Initial depression severity, comorbid panic disorder, and other psychosocial vulnerabilities were associated with a decreased response to the collaborative care intervention. Although the intervention was appropriate for patients with moderate depression, individuals with higher levels of depression may require a longer continuation phase of therapy in order to achieve optimal depression outcomes.


Subject(s)
Antidepressive Agents/therapeutic use , Depression/therapy , Patient Care Management/methods , Patient Compliance/psychology , Psychotherapy, Brief , Adult , Child , Child Abuse/psychology , Combined Modality Therapy , Depression/complications , Depression/drug therapy , Depression/psychology , Female , Health Maintenance Organizations , Humans , Loneliness/psychology , Male , Middle Aged , Odds Ratio , Panic Disorder/complications , Patient Compliance/statistics & numerical data , Primary Health Care , Prognosis , Severity of Illness Index , Treatment Outcome , Washington
17.
Arch Fam Med ; 9(10): 1052-8, 2000.
Article in English | MEDLINE | ID: mdl-11115207

ABSTRACT

OBJECTIVE: To assess effects of stepped collaborative care depression intervention on disability. DESIGN: Randomized controlled trial. SETTING: Four primary care clinics of a large health maintenance organization. PATIENTS: Two hundred twenty-eight patients with either 4 or more persistent major depressive symptoms or a score of 1.5 or greater on the Hopkins Symptom Checklist. Depression items were randomized to stepped care intervention or usual care 6 to 8 weeks after initiating antidepressant medication. INTERVENTION: Augmented treatment of persistently depressed patients by an on-site psychiatrist collaborating with primary care physicians. Treatment included patient education, adjustment of pharmacotherapy, and proactive monitoring of outcomes. MAIN OUTCOME MEASURES: Baseline, 1-, 3-, and 6-month assessments of the Sheehan Disability Scale and the social function and role limitation subscales of the Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36). RESULTS: Patients who received the depression intervention experienced less interference in their family, work, and social activities than patients receiving usual primary care (Sheehan Disability Scale, z = 2.23; P =.025). Patients receiving intervention also reported a trend toward more improvement in SF-36-defined social functioning than patients receiving usual care (z = 1.63, P =.10), but there was no significant difference in role performance (z = 0.07, P =.94). CONCLUSIONS: Significant disability accompanied depression in this persistently depressed group. The stepped care intervention resulted in small to moderate functional improvements for these primary care patients. Arch Fam Med. 2000;9:1052-1058


Subject(s)
Depressive Disorder/therapy , Primary Health Care/organization & administration , Data Collection , Depressive Disorder/diagnosis , Depressive Disorder/psychology , Female , Health Maintenance Organizations , Humans , Male , Mental Health Services , Middle Aged , Patient Care Team , Patient Education as Topic , Psychiatry , Referral and Consultation
18.
Am J Psychiatry ; 157(11): 1731-7, 2000 Nov.
Article in English | MEDLINE | ID: mdl-11058465

ABSTRACT

OBJECTIVE: This article is a discussion of the use of large clinical databases in population-based research on psychiatric disorders. METHOD: The authors review uses of large clinical databases in research on the etiology, impact, and treatment of psychiatric disorders. They also describe existing privacy safeguards applicable to use of medical records data in research. RESULTS: The growth of large medical databases has prompted increasing concern about the confidentiality of patient records. Efforts to restrict access to computerized medical data, however, may preclude use of such data in important and legitimate research. Prior research using large medical databases has made important contributions across a broad range of topics, including epidemiology, genetics, treatment effectiveness, and health policy. Continued population-based research will be essential in order to preserve the accessibility and quality of treatment for people with psychiatric disorders. CONCLUSIONS: Public domain research should be distinguished from proprietary or commercial uses of health information, and existing privacy safeguards should be vigorously applied. In our efforts to protect patient privacy, however, we should take care not to endorse or reinforce prejudices against psychiatric treatment and people who suffer from psychiatric disorders. Neither should we ignore important opportunities to improve quality of care and influence public policy through population-based research.


Subject(s)
Confidentiality , Databases as Topic/standards , Mental Disorders , Research Design/standards , Confidentiality/legislation & jurisprudence , Databases as Topic/legislation & jurisprudence , Databases as Topic/trends , Health Policy/trends , Humans , Mental Disorders/diagnosis , Mental Disorders/epidemiology , Mental Disorders/therapy , Research Design/legislation & jurisprudence , Research Design/trends , United States
19.
Am J Psychiatry ; 157(11): 1851-7, 2000 Nov.
Article in English | MEDLINE | ID: mdl-11058485

ABSTRACT

OBJECTIVE: The study examined the relationship between mental disorders and the use of complementary and alternative medicine. METHOD: Data from a national household telephone survey conducted in 1997-1998 (N=9,585) were used to examine the relationships between use of complementary and alternative medicine during the past 12 months and several demographic variables and indicators of mental disorders. Structured diagnostic screening interviews were used to establish diagnoses of probable mental disorders. RESULTS: Use of complementary and alternative medicine during the past 12 months was reported by 16.5% of the respondents. Of those respondents, 21.3% met diagnostic criteria for one or more mental disorders, compared to 12.8% of respondents who did not report use of alternative medicine. Individuals with panic disorder and major depression were significantly more likely to use alternative medicine than those without those disorders. Respondents with mental disorders who reported use of alternative medicine were as likely to use conventional mental health services as respondents with mental disorders who did not use alternative medicine. CONCLUSIONS: We found relatively high rates of use of complementary and alternative medicine among respondents who met criteria for common mental disorders. Practitioners of alternative medicine should look for these disorders in their patients, and conventional medical providers should ask their depressed and anxious patients about the use of alternative medicine. More research is needed to determine if individuals with mental disorders use alternative medicine because conventional medical care does not meet their health care needs.


Subject(s)
Complementary Therapies/statistics & numerical data , Mental Disorders/diagnosis , Adult , Attitude to Health , Depressive Disorder/diagnosis , Depressive Disorder/epidemiology , Depressive Disorder/psychology , Female , Health Care Surveys/statistics & numerical data , Humans , Male , Mental Disorders/epidemiology , Mental Disorders/therapy , Panic Disorder/diagnosis , Panic Disorder/epidemiology , Panic Disorder/psychology , Panic Disorder/therapy , Psychiatric Status Rating Scales/statistics & numerical data , Psychotropic Drugs/therapeutic use , Regression Analysis , Telephone , United States/epidemiology
20.
J Am Geriatr Soc ; 48(8): 871-8, 2000 Aug.
Article in English | MEDLINE | ID: mdl-10968289

ABSTRACT

OBJECTIVE: To examine treatment for depression among older adults in a large staff model health maintenance organization (HMO). DESIGN: A 4-year prospective cohort study (1989-1993). SETTING: Four primary care clinics of a large staff model HMO in Seattle, Washington. PATIENTS: A total of 2558 Medicare enrollees aged 65 and older. MAIN OUTCOME MEASURES: Treatment of depression was defined as primary care visits resulting in depression diagnoses, use of antidepressant medications, or specialty mental health services. MAIN RESULTS: The older adults in our sample had low rates of treatment for depression, ranging from 4 to 7% in the entire sample and from 12 to 25% among those with probable depressive disorders. Predictors of treatment included female gender, severity, and persistence of depressive symptoms, and severity of comorbid medical illness. Even when patients were treated for depression, the intensity of treatment was very low. Overall likelihood of treatment for depression increased somewhat from 1989 to 1993, but among those treated, the rate of adequate antidepressant use remained below 30%. CONCLUSIONS: There is still considerable need to improve care for older adults with depression in primary care.


Subject(s)
Depression/therapy , Depressive Disorder/therapy , Health Maintenance Organizations/statistics & numerical data , Mental Health Services/statistics & numerical data , Primary Health Care/statistics & numerical data , Aged , Aged, 80 and over , Antidepressive Agents/therapeutic use , Depression/diagnosis , Depression/etiology , Depressive Disorder/drug therapy , Depressive Disorder/etiology , Disease Management , Female , Follow-Up Studies , Health Care Surveys , Humans , Likelihood Functions , Male , Predictive Value of Tests , Prospective Studies , Risk Factors , Sex Distribution , Surveys and Questionnaires , Washington
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