ABSTRACT
Antineutrophil cytoplasmic antibody (ANCA)-positive vasculitis is an uncommon complication of the use of propylthiouracil. When it occurs, it affects multiple organs as any systemic vasculitis. We report three females and one male, aged 30, 40, 43 and 41 years respectively, that after a lapse of 12 to 28 months of propylthiouracil use, presented clinical signs of vasculitis. All had high titers of ANCA against myeloperoxidase. In three patients, a skin biopsy confirmed the diagnosis. The condition subsided when propylthiouracil was discontinued, but one female patient required the use of prednisone.
Subject(s)
Antibodies, Antineutrophil Cytoplasmic/drug effects , Antithyroid Agents/adverse effects , Propylthiouracil/adverse effects , Vasculitis/chemically induced , Adult , Antibodies, Antineutrophil Cytoplasmic/blood , Antithyroid Agents/therapeutic use , Biomarkers/blood , Biopsy , Female , Humans , Hyperthyroidism/drug therapy , Male , Propylthiouracil/therapeutic use , Vasculitis/blood , Vasculitis/pathologyABSTRACT
Antineutrophil cytoplasmic antibody (ANCA)-positive vasculitis is an uncommon complication of the use of propylthiouracil. When it occurs, it affects multiple organs as any systemic vasculitis. We report three females and one male, aged 30, 40, 43 and 41 years respectively, that after a lapse of 12 to 28 months of propylthiouracil use, presented clinical signs of vasculitis. All had high titers of ANCA against myeloperoxidase. In three patients, a skin biopsy confirmed the diagnosis. The condition subsided when propylthiouracil was discontinued, but one female patient required the use of prednisone.
Subject(s)
Adult , Female , Humans , Male , Antibodies, Antineutrophil Cytoplasmic/drug effects , Antithyroid Agents/adverse effects , Propylthiouracil/adverse effects , Vasculitis/chemically induced , Antibodies, Antineutrophil Cytoplasmic/blood , Antithyroid Agents/therapeutic use , Biomarkers/blood , Biopsy , Hyperthyroidism/drug therapy , Propylthiouracil/therapeutic use , Vasculitis/blood , Vasculitis/pathologyABSTRACT
El neumotórax espontáneo (NE) es la ocupación pleural por aire sin causa aparente. Se considera primario cuando no existe enfermedad pulmonar subyacente y secundario cuando ésta existe. Dependiendo del caso, puede ser tratado con observación, drenaje por punción, instalación de dren pleural en sello de agua y distintos tipos de cirugías. Objetivo: Estudiar las características de los pacientes por NE en nuestro centro, los tratamiento efectuados y los factores relacionados con las recidivas. Método: Revisión retrospectiva de las fichas clínicas de los pacientes hospitalizados por NIE en el HCRC entre 1990by 2000. Se estudió sexo, edad, patología asociada y etiología; tratamientos efectuados, resultados inmediatos y las recidivas. Resultados: Se estudiaron 115 pacientes, 91 (79,1 por ciento) eran hombres. Edad promedio 34,2 años. Presentaron 145 episodios de NE, 114 (78,6 por ciento) correspondieron a primer episodio, 118 (81,4 por ciento) se consideraron primarios, 111 (76 por ciento) se trataron con dren pleural, 30 (20,7 por ciento) con cirugía y 4 (2,7 por ciento) con observación. Las induicaciones quirúrgicas fueron pérdida prolongada en 14 y recidiva en 16. Las cirugías consistieron en 15 toracotomías, 9 videotoracoscopias y 6 toracotomías axilares videoasistidas. Se realizó pleurodesis en 27 pacientes y resección de bulas en 24. La histología demostró bulas subpleurales en todos los casos. La pérdida aérea promedio fue 2,4 días con dren y 2,2 postcirugía, 14 (12,6 por ciento) pacientes manejados con dren y 4 (13,3 por ciento) con cirugía tuvieron pérdida de aire > 7 días. Hubo 28 (19,2 por ciento) recidivas, 26 (23,4 por ciento) en pacientes tratados con dren, 1 (3,3 por ciento) con cirugía y 1 (25 por ciento) con observación. Las diferencias encontradas no son significativas. Conclusiones: El NE afectó a hombres en edad media de la vida. Tratamos el NE con dren pleural exclusivo e indicamos cirugía en la pérdida de aire > 7 días y las recidivas. Los resultados obtenidos son similares a otras series.
Subject(s)
Humans , Pneumothorax/surgery , Pneumothorax/complications , Pneumothorax/diagnosis , Pneumothorax/etiology , Pneumothorax/therapy , Chile , Pleurodesis , Retrospective Studies , ThoracotomyABSTRACT
El diagnóstico de megavejiga en el embarazo es infrecuente más aun si se trata de un feto femenino. Este hecho nos permite delimitar bastante las alternativas diagnósticas, dentro de un espectro bastante heterogénico. El síndrome Megavejiga-Microcolon Hipoperistalsis Intestinal(MMIHS) es una patología de muy mal pronóstico que asocia megavejiga y alteraciones intestinales severas. Es por esto que es importante tenerla presente, para poder dar a los padres una información fidedigna y certera en cuanto al pronóstico. Presentamos 2 casos de nuestro servicio en el período 1998-2003. Se comentan los aspectos diagnósticos, terapéuticos y la evolución.
Subject(s)
Humans , Female , Pregnancy , Infant, Newborn , Abnormalities, Multiple , Colon/abnormalities , Ultrasonography, Prenatal , Urinary Bladder/abnormalities , Pregnancy Trimester, SecondABSTRACT
Transgenic plants overexpressing the vacuolar H(+)-pyrophosphatase are much more resistant to high concentrations of NaCl and to water deprivation than the isogenic wild-type strains. These transgenic plants accumulate more Na(+) and K(+) in their leaf tissue than the wild type. Moreover, direct measurements on isolated vacuolar membrane vesicles derived from the AVP1 transgenic plants and from wild type demonstrate that the vesicles from the transgenic plants have enhanced cation uptake. The phenotypes of the AVP1 transgenic plants suggest that increasing the vacuolar proton gradient results in increased solute accumulation and water retention. Presumably, sequestration of cations in the vacuole reduces their toxic effects. Genetically engineered drought- and salt-tolerant plants could provide an avenue to the reclamation of farmlands lost to agriculture because of salinity and a lack of rainfall.
Subject(s)
Arabidopsis/genetics , Proton Pumps/genetics , Pyrophosphatases/genetics , Abscisic Acid/pharmacology , Arabidopsis/drug effects , Arabidopsis/enzymology , Calcimycin/pharmacology , Calcium/metabolism , Calcium/pharmacology , Kinetics , Phenotype , Plants, Genetically Modified , Plasmids , Potassium/metabolism , Restriction Mapping , Sodium/metabolism , Solutions , Vacuoles/metabolism , Water/metabolismABSTRACT
Background: Acute leukemia (AL) in infants generally shows distinctive biologic features and has a poor prognosis. Aim: To study the frequency of the cytogenetic alteration of11q23 chromosome or the recombination of MLL gene in infants less than 18 months old, with acute leukemia. Patients and methods: We analyzed 37 cases of AL in infants less than 18 months of age diagnosed in Chile from 1989 to 1999. The clinical features and cytogenetic/molecular defects of 11q23MLL gene rearrangement and their influence in prognosis were determined. Results: There were 18 cases of acute Lymphoblastic leukemia (ALL) characterized by female sex (67 per cent) high presenting leukocyte count (median 99 x109/L), blast cells with a CD10 negative phenotype (50 per cent) and 11q23/MLL rearrangement (39 per cent). Molecular abnormalities of 11q23 were significantly associated with adverse prognosis, with an event free survival (EFS) of only 14 ñ 12 per cent. Interestingly, infants with germ line 11q23 had a very good outcome with an EFS of 73 ñ 11 per cent (p<0.025). There were 19 cases of acute myeloblastic leukemia (AML) characterized by male sex (63 per cent) high leukocyte count (median 93 x 109/L), FAB-MS morphology (53 per cent) and 11q23/MLL rearrangement (53 per cent). EFS was very poor, 20 ñ 9 per cent and 33ñ4 per cent for rearranged and germinal group respectively (p=NS), due to a high mortality rate during the first month of diagnosis. Conclusions: These findings demonstrate that Chilean ALL infants with 11q23 abnormalities have a very poor prognosis. However those with germinal state can enjoy a prolonged disease free survival with the current treatment protocols
Subject(s)
Humans , Male , Female , Infant , Chromosomes, Human, Pair 11/genetics , Leukemia, Myeloid, Acute/genetics , Chromosome Aberrations/genetics , Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics , Leukemia, Myeloid, Acute/diagnosis , Cytogenetic Analysis , Precursor Cell Lymphoblastic Leukemia-Lymphoma/diagnosis , Genetic Markers/genetics , Prognosis , Recombination, Genetic/geneticsABSTRACT
Background: The incidence of acute myeloid leukemia is 3 cases per 100.000 inhabitants/year and its five years event free survival is 15 to 20 percent. Since the incorporation of trans retinoic acid, event free survival of M3 acute myeloid leukemia is 80 percent. Aim: To report the results of acute myeloid leukemia treatment at the Hospital del Salvador, between 1990 and 1998. Patients and methods: The medical records of 117 patients (66 female, mean age 48.2 years), treated between 1990 and 1998 using PANDA protocol, were retrospectively reviewed. Immunophenotyping was done in 69 patients and cytogenetic studies were done in 65. Results: Sixteen percent of patients had M3 acute myeloid leukemia. The most frequent phenotype was the association of DR, CD34 plus a panmyeloid marker. DR and CD34 were negative in seven of nine patients with M3 acute myeloid leukemia. Cariotype was abnormal in 78 percent of patients. Complete remission was achieved in 65 percent of cases with a 13 percent of failures. Early mortality was 21.3 percent and decreased to 6.1 percent in the last three years. Infections and coagulation disorders were the main causes of death. Mean survival was 10.5 months. Five years event free survival was 11 percent. In M3 acute myeloid leukemia, the figure is 50 percent. Conclusions: Treatment results are less effective than protocols that consider more aggressive chemotherapeutic protocols or bone marrow transplantation. The reduction in early mortality is due to a better management of febrile neutropenia
