ABSTRACT
OBJECTIVE: Analyze if bladder mucosa of patients with bladder pain syndrome (BPS) have more estrogen receptor (ER) and progesterone receptor (PR) than the normal population. MATERIAL AND METHOD: Between July 2009 and December 2010, 15 female patients with chronic bladder pain syndrome and 10 female patients without bladder pain were enrolled in the present study. Three pieces of trigonal bladder mucosa were biopsied and sent for estrogen receptor and progesterone receptor immunohistochemistry staining by the Benchmark automated machine. The results were reported as positive and negative and then compared between the two groups. RESULTS: Estrogen receptor was found in 14 out of 15 patients in the BPS group (93%) and in 7 out of 10 patients in the control group (70%). Progesterone receptor was found in 10 out of 15 patients in the BPS group (66.7%) and 5 out of 10 patients in the control group. Both were not significantly different with p = 0.267 and p = 0.678, respectively. CONCLUSION: The authors concluded that ER and PR might not play a role in the etiopathogenesis of BPS/IC. However other receptors should be further investigated about their role in this type of pain.
Subject(s)
Cystitis, Interstitial/pathology , Immunohistochemistry , Pelvic Pain/pathology , Receptors, Estrogen/analysis , Receptors, Progesterone/analysis , Adult , Aged , Biopsy , Case-Control Studies , Cystitis, Interstitial/diagnosis , Cystitis, Interstitial/therapy , Cystoscopy , Dilatation , Female , Humans , Male , Middle Aged , Mucous Membrane/pathology , Pelvic Pain/etiology , Pelvic Pain/therapy , Syndrome , Urinary Bladder/pathology , Urination Disorders/diagnosis , Urination Disorders/pathology , Urination Disorders/therapy , Young AdultABSTRACT
BACKGROUND: To present our experience with Laparo-Endoscopic Single Site (LESS) management of benign kidney diseases. MATERIAL AND METHOD: Between September 2008 and November 2009, 18 patients underwent single port transumbilical laparoscopic surgery for nephrectomy for a nonfunctioning kidney (7 cases), cyst decortications for symptomatic renal cyst (10 cases), and redo-dismembered pyeloplasty with previously failed laparoscopic surgical repair (1 case). Patients underwent surgery through a single 2-cm infraumbilical incision with the triport laparoscopic-port. All pathological reports of LESS nephrectomy and cyst decortications confirmed with chronic pyelonephritis and simple cysts, respectively Histology of xanthogranulomotus pyelonephritis showed two cases of the nephrectomy procedure. RESULTS: Mean patient age and BMI were 61 +/- SD 14.2 years and 24.75 +/- SD 11.2 kg/m2, respectively Mean operating time was 187.7 +/- SD 71.4 min. LESS was a possible and safe approach in 77.8% of patients. All LESS cyst decortications and redo-pyeloplasty were completed without major complications or conversion to open surgery. However, there was one case each of LESS cyst decortication and pyeloplasty requiring an additional 3-mm port for suturing due to bleeding and an instrument error. For LESS nephrectomy, two (28.6%) with higher waist circumference were converted to standard laparoscopic nephrectomy due to failure to progress. One post operative complication of incisional hernia occurred in a patient with chronic bronchitis and asthma. CONCLUSION: LESS for the management of benign kidney diseases is an effective and safe treatment option with selected patients and experienced surgeon.
