ABSTRACT
BACKGROUND: 5-Fluorouracil therapy is an efficacious treatment for actinic keratoses. However, the prolonged courses of therapy traditionally prescribed are unpleasant, uncomfortable, and can lead to noncompliance. OBJECTIVE: To treat patients with shorter courses of 5-fluorouracil therapy. METHODS: 5-Fluorouracil cream or solution is applied four times daily for periods varying between 7 and 21 days, depending upon the body location. RESULTS: The same brisk inflammatory reaction and clearing of the majority of actinic keratoses associated with longer courses of application twice daily is realized. CONCLUSION: 5-Fluorouracil can be applied four times daily for shorter periods of time, resulting in clearing of actinic keratoses and patient acceptability.
Subject(s)
Fluorouracil/administration & dosage , Keratosis/drug therapy , Sunlight/adverse effects , Administration, Topical , Drug Evaluation , Drug Therapy, Combination , Humans , Ointments , Time FactorsABSTRACT
Many systemic diseases may involve the skin and the eye. In some of these disorders, with both prominent ocular and cutaneous manifestations, the clinical findings, pathology, and pathophysiology may be quite similar; in other instances, quite diverse. Most dermatologists are well aware of the cutaneous manifestations of these disorders, but many of us may be unaware of the associated ophthalmologic findings. This article emphasizes and reviews the ocular manifestations of these diseases, hopefully enabling the dermatologist to make timely and appropriate referral to the ophthalmologic consultant.
Subject(s)
Eye Diseases/etiology , Skin Diseases, Vesiculobullous/complications , Adrenal Cortex Hormones/therapeutic use , Collagen Diseases/complications , Collagen Diseases/immunology , Collagen Diseases/therapy , Eye/drug effects , Eye Diseases/therapy , Humans , Metabolic Diseases/complications , Skin Diseases, Vesiculobullous/therapyABSTRACT
We describe two patients with Sweet's syndrome and acute renal failure requiring dialysis. One patient developed end-stage renal disease; the other died from acute renal failure. We recommend that patients with Sweet's syndrome be evaluated for concomitant renal disease and suggest that a common pathogenesis may produce cutaneous and renal lesions in some cases.
Subject(s)
Acute Kidney Injury/diagnosis , Dermatitis/diagnosis , Neutrophils , Adult , Aged , Female , Humans , Renal Dialysis , SyndromeABSTRACT
Expedient and simple surgery with excellent cosmetic results can be accomplished by use of Robbins punches. Techniques for excision of very small basal cell carcinomas from the nose, with and without grafting, and rapid excision of multiple lesions such as dysplastic nevi are outlined.
Subject(s)
Dermatologic Surgical Procedures , Carcinoma, Basal Cell/surgery , Humans , Methods , Nevus/surgery , Skin Neoplasms/surgery , Surgical Instruments , Suture TechniquesABSTRACT
A patient with a 10-year history of an acquired, scarring bullous eruption localized to the anterior surfaces of the lower extremities is described. Clinical, histologic, and electron microscopic features of an acquired form of epidermolysis bullosa are shown to occur in the absence of immune deposits, a finding not previously documented.
Subject(s)
Antigen-Antibody Complex/analysis , Epidermolysis Bullosa/immunology , Skin/pathology , Aged , Epidermolysis Bullosa/pathology , Humans , Immunoenzyme Techniques , Male , Microscopy, Electron , Skin/immunologyABSTRACT
A 2 1/2-year-old white girl with citrullinemia accompanied by neurologic symptoms presented with 2- to 3-week loss of scalp hair. Examination of the scalp revealed 90% of the hairs to be broken off, leaving a stubble of hairs less than 1 mm in length. Microscopically, plucked hairs demonstrated flattening, twisting through 180 degrees on its own axis, and breakage at the point of twisting. A diagnosis of pili torti was established. Pili torti is a rare disorder that may be seen with some genetic syndromes. Its association with citrullinemia has not been reported previously.
