ABSTRACT
A 50-year-old man was diagnosed with hypersensitivity pneumonitis caused by the environment of his bar owing to worsening symptoms, laboratory test results, and computed tomography images after an environmental inhalation challenge test. His hypersensitivity pneumonitis exacerbated despite receiving prednisolone 20 mg/day. The patient underwent allogeneic hematopoietic stem cell transplantation (HSCT) from a human leukocyte antigen-matched unrelated donor for myelodysplastic syndrome. No exacerbation of hypersensitivity pneumonitis was observed after HSCT. An environmental inhalation challenge test involving exposure to his bar confirmed the remission of hypersensitivity pneumonitis after HSCT. This case demonstrates that hypersensitivity pneumonitis can be remitted by HSCT.
ABSTRACT
The concurrent incidence of lung cancer and tuberculosis is expected to escalate due to the projected growth in the older population. Combination therapy with osimertinib and antituberculosis drugs has not been well-established. We report a case of successful treatment involving the concomitant administration of osimertinib and antituberculosis drugs in an older patient, an 89-year-old female, diagnosed with epidermal growth factor receptor (EGFR)-mutant lung cancer and pulmonary tuberculosis. Accumulating evidence is warranted to develop an optimal treatment strategy for patients with lung cancer and tuberculosis.
Subject(s)
Acrylamides , Aniline Compounds , Antitubercular Agents , ErbB Receptors , Lung Neoplasms , Mutation , Tuberculosis, Pulmonary , Humans , Acrylamides/therapeutic use , Aniline Compounds/therapeutic use , Aniline Compounds/pharmacology , Lung Neoplasms/drug therapy , Lung Neoplasms/genetics , Lung Neoplasms/pathology , Female , ErbB Receptors/genetics , Tuberculosis, Pulmonary/drug therapy , Aged, 80 and over , Antitubercular Agents/therapeutic use , Indoles , PyrimidinesABSTRACT
Oral benzine intake with suicidal tendencies is an uncommon life-threatening respiratory emergency without a treatment regimen. A 50-year-old man attempted suicide with 100 ml of oral benzine intake and developed severe acute respiratory distress syndrome (ARDS) with hydrocarbon aspiration. He received mechanical ventilation with placement in the prone position and low tidal volume, neuromuscular blocking agents, bronchoalveolar lavage, steroid pulse therapy, antibiotics, and sivelestat sodium hydrate. He was transferred to the psychiatric hospital five days after admission without any adverse events. ARDS associated with oral benzine intake could be treated with general treatments for ARDS.
