ABSTRACT
To investigate whether left ventricular performance can be described independent of loading conditions, twelve patients underwent intraoperatively two cineangiographies of the left ventricle with simultaneous pressure recordings. The first ventriculography was performed with ejecting left ventricle without assistance by the extracorporeal circulation. The second one was performed with ejecting left ventricle partially unloaded by the extracorporeal circulation. Myocardial perfusion pressure (mean aortic pressure) was held constant. Due to this procedure marked decreases in preload (end-diastolic wall stress: -54%) and modest changes in afterload (mean systolic wall stress: -23%) were achieved. End-diastolic volume index was reduced from 84 ml/m2 to 57 ml/m2, whereas end-systolic volume index decreased slightly from 33 ml/m2 to 29 ml/m2. Left ventricular end-diastolic pressure decreased from 12 mm Hg to 7 mm Hg, while peak pressure remained nearly unchanged. Usual parameters of ejection phase (EF, Vmw) as well as power per wall volume (PW) were markedly affected by unloading. In contrast to these parameters, the power index (PI), i.e., the ratio of power per wall volume and end-diastolic wall stress, remained unchanged when left ventricular preload was reduced: PI under control: 5.2 +/- 1.8 sec-1; PI under unloading: 5.2 +/- 1.5 sec-1. This power index can easily be determined from routine angiographies. It may provide a new approach to the assessment of left ventricular function in man.
