ABSTRACT
AIM: There remains conflicting opinions regarding the relationship between the risk of cardiovascular disease and subclinical hypothyroidism (SH), and there are also varying study results. Recent growing evidence suggests that epicardial adipose tissue (EAT) may play a key role in the pathogenesis and development of coronary artery disease. The effects of SH on echocardiographic EAT is not currently known. The aim of this present study was to measure echocardiographic EAT with anthropometric and clinical parameters in patients with SH. METHODS: The study was designed as a prospective and case-controlled study. Body fat ratio, echocardiographic EAT measurements, body mass index, and the waist circumference of patients were measured for analysis. RESULTS: Epicardial adipose tissue was measured to be 3.83±1.04 mm for patients with SH, while it was measured to be 2.81±0.74 mm in the control group, and there was a significant difference detected between two groups (P<0.001). CONCLUSION: In the present study significantly increased EAT in patients with SH was detected.
Subject(s)
Adipose Tissue/metabolism , Hypothyroidism/etiology , Pericardium , Adipose Tissue/diagnostic imaging , Adult , Body Mass Index , Case-Control Studies , Coronary Artery Disease/etiology , Echocardiography , Female , Humans , Hypothyroidism/complications , Male , Metabolic Syndrome/complications , Metabolic Syndrome/etiology , Middle Aged , Prospective Studies , Risk Factors , Thyroid Function Tests , Waist CircumferenceABSTRACT
AIM: It is generally impossible to make a distinction between benign and malign with a cytopathological examination using a fine needle aspiration biopsy (FNAB) in follicular lesions of the thyroid gland. This is the reason why lesions are frequently reported as follicular neoplasia (FN). Our study aims to examine the predictive value of carcinoma detection of different clinical features in cases with determined FN with FNAB. METHODS: Clinical and histopathological data of a total of 116 patients (26 male, 90 female) subjected to surgery because of thyroid gland pathology with FN between March 1997 and December 2011 were retrospectively examined in two different centers. RESULTS: Results of the histopathological examinations were reported as: carcinoma in 33 (28.4%) cases (18 [54.5%] cases with papillary thyroid cancer, 11 [33.3%] cases with follicular thyroid cancer and 4 [12.1%] cases with papillary thyroid cancer follicular variant), as follicular adenoma (FA) in 32 (27.6%) patients and as a benign colloidal nodule in 51 (43.9%) patients. No statistical significance was determined between advanced age, male sex, solid single nodule, increased nodule diameter, hypoactive nodule existence and malignancy (P>0.05). CONCLUSION: Malignancy was found in 28.4% cases with FN detected as a result of FNAB in our study series, a ratio which is significantly higher than that reported in the literature. We think that the characteristics of the patient and the tumor are not effective in diagnosing cancer. In the case of the existence of bilateral thyroid pathology, the surgical therapy option should be bilateral total thyroidectomy due to such a high ratio of cancer occurrence.
