Current paradigms in employing self-assembled structures: Drug delivery implications with improved therapeutic potential.

Recent efforts have focused on developing improved drug delivery systems with enhanced therapeutic efficacy and minimal side effects. Micelles, self-assembled from amphiphilic block copolymers in aqueous solutions, have gained considerable attention for drug delivery. However, there is a need to further enhance their efficiency. These micelles offer benefits like biodegradability, biocompatibility, sustained drug release, and improved patient compliance. Yet, researchers must address stability issues and reduce toxicity. Nanoscale self-assembled structures have shown promise as efficient drug carriers, offering an alternative to conventional methods. Fine-tuning at the monomeric and molecular levels, along with structural modifications, is crucial for optimal drug release profiles. Various strategies, such as entrapping hydrophobic drugs and using polyethylene oxide diblock copolymer micelles to resist protein adsorption and cellular adhesion, protect the hydrophobic core from degradation. The polyethylene oxide corona also provides stealth properties, prolonging blood circulation for extended drug administration. Amphiphilic copolymers are attractive for drug delivery due to their adjustable properties, allowing control over micelle size and morphology. Emerging tools promise complex and multifunctional platforms. This article summarizes about the challenges as far as the use of micelles is concerned, including optimizing performance, rigorous pre-clinical and clinical research, and suggests further improvement for drug delivery efficacy.

Current paradigms in epigenetic anticancer therapeutics and future challenges.

Any alteration at the genetic or epigenetic level, may result in multiplex of diseases including tumorigenesis which ultimately results in the cancer development. Restoration of the normal epigenome by reversing the epigenetic alterations have been reported in tumors paving the way for development of an effective epigenetic treatment in cancer. However, delineating various epigenetic events has been a challenging task so far despite substantial progress in understanding DNA methylation and histone modifications during transcription of genes. Many inhibitors in the form of epigenetic drugs mostly targeting chromatin and histone modifying enzymes including DNA methyltransferase (DNMT) enzyme inhibitors and a histone deacetylases (HDACs) inhibitor, have been in use subsequent to the approval by FDA for cancer treatment. Similarly, other inhibitory drugs, such as FK228, suberoylanilide hydroxamic acid (SAHA) and MS-275, have been successfully tested in clinical studies. Despite all these advancements, still we see a hazy view as far as a promising epigenetic anticancer therapy is concerned. The challenges are to have more specific and effective inhibitors with negligible side effects. Moreover, the alterations seen in tumors are not well understood for which one has to gain deeper insight into the tumor pathology as well. Current review focusses on such epigenetic alterations occurring in cancer and the effective strategies to utilize such alterations for potential therapeutic use and treatment in cancer.

Recent patents on therapeutic activities of xanthohumol: a prenylated chalconoid from hops (Humulus lupulus L.).

There is expanding proof that specific natural compounds found in plants have additional conventional medicinal properties. One such compound is xanthohumol (XN), which is being explored as an antimicrobial, anticarcinogenic, antidiabetic and anti-inflammatory agent - aside from its utilization in dealing with conditions like autism, bone and skin improvement and microbial infections, lipid-related illnesses, and so on. XN is reported to suppress the uncontrolled production of inflammatory mediators responsible for diseases including cardiovascular disease, neurodegeneration and tumors. Further, it is accounted to limit adipogenesis and control obesity by focusing on principal adipocyte marker proteins. It is most generally utilized in the brewing industry as an additive and flavoring agent to add bitterness and aroma to beer. Present investigation sum up the patents filed in most recent 2 years on development of different pharmaceutical mixes and strategies dependent on various therapeutic potentials of XN.

COVID-19 Pandemic: from Molecular Biology, Pathogenesis, Detection, and Treatment to Global Societal Impact.

PURPOSE OF REVIEW: In December 2019, there was an outbreak of viral disease in Wuhan, China which raised the concern across the whole world. The viral disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or novel coronavirus or COVID-19 (CoV-19) is known as a pandemic. After SARS-CoV and Middle East respiratory syndrome (MERS)-related CoV, COVID-19 is the third most pathogenic virus, hazardous to humans which have raised worries concerning the capacity of current security measures and the human services framework to deal with such danger. RECENT FINDINGS: According to WHO, the mortality rate of COVID-19 exceeded that of SARS and MERS in view of which COVID-19 was declared as public health emergency of international concern. Coronaviruses are positive-sense RNA viruses with single stranded RNA and non-segmented envelopes. Recently, genome sequencing confirmed that COVID-19 is similar to SARS-CoV and bat coronavirus, but the major source of this pandemic outbreak, its transmission, and mechanisms related to its pathogenicity to humans are not yet known. SUMMARY: In order to prevent the further pandemic and loss to humanity, scientists are studying the development of therapeutic drugs, vaccines, and strategies to cure the infections. In this review, we present a brief introduction to emerging and re-emerging pathogens, i.e., coronavirus in humans and animals, its taxonomic classification, genome organization, its replication, pathogenicity, impact on socioeconomic growth, and drugs associated with COVID-19.

Ecological morphotaxometry of trematodes of garfish (Teleostomi: Belonidae) from Gangetic riverine ecosystem in India. III. Principal component analysis in the dynamics of Cephalogonimus yamunii (Upadhyay, Jaiswal, Malhotra and Malhotra, 2012).

The attributes of multivariate analyses were applied to infer peculiarity in distribution dynamics of Cephalogonimus yamunii Upadhyay et al. (J Parasit, 2012) in Xenentodon cancilla under influence of interionic interactions amongst hydrobiological factors. Non-parametric Mann-Whitney's Test χ(2) statistic was significant for the effect of Dissolved Oxygen and magnesium. The temperature optimum 23-27 °C was concluded for expression of peak prevalence and mean intensity during change in water temperature between autumn and winter periods. The dominant Ist component (PC1 (p) ) from Principal Component Analysis of monthwise response of infection data by C. yamunii in X. cancilla was further confirmed by Scree Plot of Eigenvalues and Factor Loadings Plot to identify the critical impact of hardness of water on infection prevalence and mean intensity. The findings of larger PC1 (p) positive coefficients comprehensively substantiated predominating hardness factor, under the influence of enhanced Dissolved Oxygen and optimum thermal effect. Therefore, the role of multifactorial etiology is a definite possibility.

Ecological morphotaxometry of trematodes of garfish (Teleostomi: Belonidae) from Gangetic riverine ecosystem in India. II. Correlation of seasonality and host biology with distribution pattern of Cephalogonimus yamunii n.sp.

The seasonality influence on the biology and distribution dynamics of Cephalogonimus yamunii n.sp. in Xenentodon cancilla (Teleostomi: Belonidae) was reflected during 2 years' investigations. The highest infection prevalence appeared to be in late summer. Size, weight, and sex-biased population dynamics of trematode was well marked in Gangetic riverine ecosystem. The biostatistical non-parametric Mann-Whitney χ (2) test values were significant for dissolved oxygen and magnesium. The distribution of infection data on Poisson series ruled out overdispersion because good agreement was observed (P < 0.01).

Ecological morphotaxometry of trematodes of garfish (Teleostomi: Belonidae) from Gangetic riverine ecosystem in India. I. Morphology and taxometric assessment of Cephalogonimus yamunii n.sp.

A new endoparasitic fluke, Cephalogonimus yamunii n.sp. is described from the intestine of freshwater fish Xenentodon cancilla (Belonidae). The worms could be differentiated from C. amphiumae (Chandler 1932), C. apognichthysi (Gupta and Puri 1982), C. hanumanthai (Agrawal and Agarwal 1984), C. salamandrus (Dronen and Lang 1974), C. simhai (Singh 2010) and C. vesicaudus (Nickerson 1912) in a unipartite seminal vesicle, genital pore subterminal anteriorly, opening at the hind end of oral sucker, equatorial or sub-equatorial testes, besides other morphological attributes of shorter body and pharynx, larger oesophagus and oral sucker, smaller ventral sucker, testes, cirrus sac and ovary, and a terminal excretory pore. Taxometric substantiation has been presented by using Polythetic Divisive Classificatory System, and ecological attributes have been evaluated to validate specific distribution patterns in population dynamics of the new species in simultaneous contributions.