1.
Bioorg Med Chem Lett
; 11(6): 773-6, 2001 Mar 26.
Article
in English
| MEDLINE
| ID: mdl-11277517
ABSTRACT
A novel synthetic strategy is described which may be used to prepare analogues of the antimalarial, fungal metabolite apicidin. Compared to the natural product, one analogue shows potent and selective activity in vitro against the parasite Trypanosoma brucei and low mammalian cell toxicity.
Subject(s)
Peptides, Cyclic/chemical synthesis , Trypanocidal Agents/chemical synthesis , Animals , Parasitic Sensitivity Tests , Peptides, Cyclic/chemistry , Peptides, Cyclic/pharmacology , Trypanocidal Agents/chemistry , Trypanocidal Agents/pharmacology , Trypanosoma brucei brucei/drug effects
2.
Bioorg Med Chem Lett
; 9(4): 605-10, 1999 Feb 22.
Article
in English
| MEDLINE
| ID: mdl-10098673
ABSTRACT
Several racemic bicyclo[3.2.1]octene derivatives have been synthesised and evaluated as inhibitors of influenza virus sialidases. The 5-acetamido-bicyclo[3.2.1]octenol 4 showed modest activity against influenza A and B virus sialidases.
Subject(s)
Bridged Bicyclo Compounds, Heterocyclic/chemical synthesis , Enzyme Inhibitors/chemical synthesis , Influenza A virus/enzymology , Influenza B virus/enzymology , Neuraminidase/antagonists & inhibitors , Bridged Bicyclo Compounds, Heterocyclic/pharmacology , Enzyme Inhibitors/pharmacology
3.
J Med Chem
; 41(21): 3919-22, 1998 Oct 08.
Article
in English
| MEDLINE
| ID: mdl-9767628
