ABSTRACT
A 75-year-old male visited our hospital with bilateral hilar lymph node swelling detected on chest radiography during an annual medical checkup. Chest computed tomography revealed swelling of multiple hilar mediastinal lymph nodes. Histopathological and immunohistochemical examinations of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) specimens from the hilar lymph nodes revealed amyloid deposition. Bilateral hilar and mediastinal lymphadenopathies can be the first manifestations of amyloidosis diagnosed using EBUS-TBNA.
Subject(s)
Amyloidosis , Lung Neoplasms , Lymphadenopathy , Male , Humans , Aged , Lung Neoplasms/diagnosis , Lymphadenopathy/etiology , Lymphadenopathy/pathology , Mediastinum/pathology , Lymph Nodes/pathology , Amyloidosis/complications , Amyloidosis/diagnosis , Bronchoscopy/methodsABSTRACT
Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are common therapeutic agents for EGFR mutation-positive advanced non-small-cell lung cancer. There has been no report of rhabdomyolysis caused by an overdose of EGFR-TKIs. We herein review the existing literature on the subject and report a rare case of rhabdomyolysis due to an overdose of gefitinib, an EGFR-TKI.
