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2.
Farmakol Toksikol ; 40(4): 468-71, 1977.
Article in Russian | MEDLINE | ID: mdl-902751

ABSTRACT

Tests set up on the isolated perfused lungs of albino rats and on intact dogs demonstrated that the serotonin absorption by the pulmonary tissue is attended by a drop of the ATP amount in the lungs. The exogenous ATP has no essential effect on the serotonin absorption by the pulmonary tissue, its considerable quantities being metabolized in the pulmonary capillaries.


Subject(s)
Adenosine Triphosphate/physiology , Lung/metabolism , Serotonin/metabolism , Adenosine Diphosphate/metabolism , Adenosine Monophosphate/metabolism , Adenosine Triphosphate/metabolism , Adenosine Triphosphate/pharmacology , Animals , Dogs , In Vitro Techniques , Lung/drug effects , Rats
5.
Fiziol Zh SSSR Im I M Sechenova ; 61(2): 257-61, 1975 Feb.
Article in Russian | MEDLINE | ID: mdl-1140442

ABSTRACT

The optimal heart-rate was studied in natural conditions of hemodynamics and on stabilizing the left ventricle load and volume with a balloon. The coronary blood-flow was traced with the aid of electromagnetic fluorometer. Post-occlusion reactive hyperemia estimated reserves of the coronary blood-flow. On stabilizing the left ventricle load and volume, its contractility was higher with faster heart-rate. With the fastest heart-rate, a considerable reserve of the coronary blood-flow was still preserved. Apparently under conditions of natural hemodynamics, the optimal heart-rate (100-180/min) and the decline of contractility with fast heart-rate are due to decrease in filling of the heart caves with the blood per 1 sistole at a constant 1 min volume of the blood-flow.


Subject(s)
Heart Rate , Animals , Blood Pressure , Coronary Circulation , Dogs , Heart Ventricles , Myocardial Contraction
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