[The extent of coronary stenosis and the level of antibodies to atherogenic lipoproteins in patients with coronary heart disease].

AIM: To study association between the level of antibodies to oxidized low-density lipoproteins (anti-OLDL) and the extent of coronary stenosis (CS) in patients with coronary heart disease (CHD). MATERIAL AND METHODS: Sixty CHD patients were examined for titer of anti-OLDL, levels of total cholesterol (TC), LDLP cholesterol, HDLP cholesterol, triglycerides. Selective coronarography (SC) was made on demand. RESULTS: Elevated titer of anti-OLDL was found only in 12 examinees. It was significantly lower in CHD women than in men. No significant differences by anti-OLDL were found in CHD patients with and without significant risk factors. SC registered in all CHD examinees local stenosis of different severity. Stenosis in 3 coronary arteries was detected in 31 cases, in 2 coronary arteries--in 14, in 1 coronary artery--in 15 patients, most frequently the affection was located in the diagonal branch of the left coronary artery. Stenosis of the left coronary artery trunk was diagnosed in one case. The correlation analysis revealed a strongly significant positive correlation between content of anti-OLDL and the degree of CS. CONCLUSION: The level of anti-OLDL in CHD patients directly correlates with the degree of CS and is a marker of coronary atherosclerosis severity.

[Antiphospholipid activity of the blood in patients with ischemic heart disease and thrombogenic complications]. / Antifosfolipidnaia aktivnost' krovi u bol'nykh ishemicheskoi bolezn'iu serdtsa s trombogennymi oslozhneniiami.

The authors propose a method of estimating antiphospholipid activity of blood by phospholipids (PL) assays in circulating immune complexes (CIC). Screening of PL in CIC is an additional test in examination of patients with ischemic heart disease associated with thrombogenic complications and suspected antiphospholipid syndrome.

[Influenza virus infection in progressing atherosclerosis]. / Infektsiia virusami grippa pri progressiruiushchem ateroskleroze.

AIM: To study relationship between influenza virus infection and activity of clinical presentations of atherosclerosis. METHODS AND RESULTS: Average blood level of IgG to influenza A virus was significantly higher in patients with progressing forms of ischemic heart disease then in patients without objective signs of exacerbation of atherosclerotic process. Mean titles of antibodies to parainfluenza virus and adenoviruses were similar in both groups of patients. Direct detection of viral DNA by polymerase chain reaction was carried out in samples of aortic wall taken during coronary artery bypass surgery with the use of primers for hemagglutinin of H1N1, H3N2 viruses. RNA of influenza virus was found in these samples. CONCLUSION: The presence of viral RNA in vascular atherosclerotic lesions could be indicative of possible pathogenetic role of influenza infection in progression of clinical course of atherosclerosis.

[Pathogenetic significance of cholesterol-containing immune complexes and lipid peroxidation in ischemic heart disease]. / Patogeneticheskoe znachenie soderzhashchikh kholesterin tsirkuliruiushchikh immunnykh kompleksov i perekisnogo okisleniia lipidov pri ishemicheskoi bolezni serdtsa.

AIM: To ascertain a relationship between cholesterol content in circulating immune complexes (CIC) and plasm lipid peroxidation (LPO) in patients with ischemic heart disease (IHD). MATERIALS AND METHODS: Blood samples from 33 IHD patients 23 of which had a history of myocardial infarction and from 8 healthy subjects were examined for total cholesterol, high and low density lipoproteins cholesterol, CIC, the ability of blood serum to induce free radicals, superoxide dismutase. RESULTS: A statistically significant positive correlation was found between CIC cholesterol level and content of free radicals while a negative correlation existed between superoxide dismutase activity and high density lipoprotein cholesterol level in blood plasm of healthy individuals and patients with IHD. After myocardial infarction an inversion of the above parameters was seen as a result of disorders in both antioxidant and immune systems. CONCLUSION: The level of both LPO and CIC cholesterol, their interaction are important atherogenic factors in development of IHD.

[The effect of thrombolytic therapy with the preparation APSAC on the course of myocardial infarct]. / Vliianie tromboliticheskoi terapii preparatom APSAC na techenie infarkta miokarda.

To evaluate the influence of thrombolytic therapy (TT) on the course of acute myocardial infarction (AMI), a comparative analysis of clinical and pathological findings was conducted. The latter included post mortem examination of 35 myocardial samples from patients treated with APSAC in the acute phase of the infarction. The analysis indicated the predominance of cases with unfavourable coronary heart disease, severe myocardial damage and severe AMI complications in the group of the decreased patients. The following beneficial effects of TT were reported: relatively safe stromal and parenchymal myocardial components, earlier regeneration of the connective tissue. Late TT had a negative effect on MI because more hemorrhagic infarctions occurred. The combination of TT and myocardial repair modulators is proposed.