ABSTRACT
We describe the worsening of porphyria cutanea tarda in a young woman while she was taking oral contraceptives. However, she did not have an exacerbation during two pregnancies. We conclude that estrogens produced during pregnancy do not exert the same effect as orally administered medications that contain estrogen. The pronounced effect of oral ethinyl estradiol on the liver may be attributed to its first-pass effect on that organ.
Subject(s)
Contraceptives, Oral, Synthetic/adverse effects , Mestranol/adverse effects , Norethindrone/adverse effects , Porphyria Cutanea Tarda/chemically induced , Porphyria Cutanea Tarda/metabolism , Pregnancy Complications/metabolism , Adult , Contraceptives, Oral, Combined/adverse effects , Contraceptives, Oral, Combined/metabolism , Contraceptives, Oral, Synthetic/metabolism , Drug Combinations , Estrogens/biosynthesis , Estrogens/metabolism , Female , Humans , Infant, Newborn , Male , Mestranol/metabolism , Norethindrone/metabolism , PregnancyABSTRACT
Epidermal cells from 8 patients with psoriasis (involved and uninvolved areas) and from 7 normal individuals, were propagated in vitro. DNA synthesis was determined autoradiographically by measuring the labeling index (1 hr) and a continuous labeling index (72 hr) on 8-10 day old cell cultures. No differences in these 2 kinetic parameters were obtained with respect to involved and uninvolved psoriatic cells. However, when psoriatic cells (involved and uninvolved) were compared to normal cells, the psoriatic cells exhibited a much higher labeling index and continuous labeling index, 200-300% and 60-70% respectively. These data clearly show that in vitro (1) epidermal cells from clinically uninvolved skin of psoriatics proliferate at a rate equal to that of involved psoriatic cells and (2) psoriatic epidermal cells proliferate at a rate greater than normal cells.
Subject(s)
DNA/biosynthesis , Epidermis/metabolism , Psoriasis/metabolism , Adolescent , Adult , Aged , Cells, Cultured , Female , Humans , Male , Middle Aged , ThymidineABSTRACT
Two cases of smooth muscle hamartoma with Becker's nevus are reported. Clinically and histologically the lesions resemble Becker's nevi with the exception that on histologic examination a hamartomatous proliferation of smooth muscle is prominent.
