ABSTRACT
No disponible
Subject(s)
Humans , Glucuronidase/blood , Thyroid Diseases/diagnosis , Biomarkers/analysis , ColorimetryABSTRACT
No disponible
Subject(s)
Humans , Male , Female , Aged , Paraproteinemias/diagnosis , Antibodies, Monoclonal/analysis , Monoclonal Gammopathy of Undetermined Significance/diagnosisABSTRACT
Objetivos.- Estudiar la reacción biológica proteica (alfa 1- glicoproteína ácida, alfa 1- antitripsina, haptoglobina y PCR) en la trombocitemia esencial y en las trombocitosis reactivas. Material y métodos.- Se estudiaron 50 pacientes con recuento plaquetario mayor de 600 por 10g/l. Como criterio diagnóstico de la trombocitemia esencial se usó el del Polycythemia Vera Study Group. Las trombocitosis reactivas se definieron ante la ausencia del síndrome mieloproliferativo crónico y la existencia de otras causas de trombocitosis secundaria (infección, neoplasia, deficiencia de hierro). El recuento plaquetario se realizó en un contador automático de células; los reactantes de fase aguda se cuantificaron por inmunodifusión radial de Mancini, usando placas NOR- Partigen y LC Partigen. Resultados.- De los 50 pacientes 25 tenían trombocitemia esencial (13 hombres y 12 mujeres) y 25 trombocitosis reactiva (10 hombres y 15 mujeres). Secundarias a infección (5 casos), neoplasia (8 casos), deficiencia férrica (8 casos), posthermorrágica (3 casos) y postesplenectomía (1 caso). La concentración sérica de reactantes de fase aguda estaba más elevada en las trombocitosis reactivas que en la trombocitemia esencial (p<0.01). Conclusiones.- En las trombocitosis reactivas alfa 1- glicoproteína ácida, alfa 1 antitripsina, haptoglobina y PCR estaban significativamente más elevada que en la trombocitemia esencial. El estudio de los reactantes de fase aguda es un test simple, barato y rentable para usarlo en el diagnóstico diferencial entre la trombocitemia esencial y las trombocitosis reactivas
Aim.- To study the proteic biological reactants : alpha 1- AGP, alpha 1- AT, Hp and CRP. Matherial and method. A total of 50 patients with platelet count of > 600 for 10 g/l. Polycythemia Vera Study Group criteria were used in the diagnosis of essential thrombocitemia. Reactive thrombocytosis was defined when there was no history of chronic myeloproliferative syndrome but did other causes of secondary thrombocytosis (infection, neoplasia, iron deficiency). Platelet count were obtained by automated cell counter. Acute phase reactants were quantified by radial immunodiffusion, according to Mancini et al, using NOR Partigen an LC Partigen plates. Results.- Of 50 patients, 25 had essential thrombocythemia (13 males and 12 females) and 25 has reactive thrombocytosis (10 males and 15 females), infection in 5 cases, neoplasia in 8 cases, iron deficiency in 8 cases, posthaemorrage in 3 cases and postesplenectomy in 1 case). The serum concentration of the acute- phase reactants were found to be more elevated in reactive thrombocytosis than in essential thrombocythaemia (p<0.01). Conclusion.- In reactive thrombocytosis (alpha 1- AGP, alpha 1 AT, Hp and CRP) were found to be significantly elevated compared with patients with essential thrombocythaemia. The study of acute- phase reactants is a simple, inexpensive, profitable and useful test in differential diagnosis between essential thrombocythaemia and reactive thrombocythosis
Subject(s)
Humans , Thrombocythemia, Essential/physiopathology , Thrombocytosis/physiopathology , Acute-Phase Proteins/analysis , Acute Disease , Orosomucoid/analysis , alpha 1-Antitrypsin/analysis , Haptoglobins/analysis , C-Reactive Protein/analysisABSTRACT
Se aportan tres casos de carotenodermia dietética tras la ingestión abundante de alimentos ricos en carotenos (zanahorias, naranjas). Se trata de dos varones y una mujer, adultos jóvenes, dos de ellos con antecedentes psicopatológicos. El principal problema clínico que plantean es la posible confusión con ictericias, aunque la pigmentación es sólo cutánea, no de escleróticas, la tonalidad es amarillo-anaranjada y la determinación de bilirrubina normal. La confirmación del diagnóstico se hace por la cuantificación de carotenos, que están elevados (AU)
There are three cases of dietetic carotenodermia after the great ingestion of food which is rich in carotenoids (carrot, oranges). There are two men and a woman, they are young adults, two of them have previous psicopathologics. The main clinic problem which appears is the possible mistake with icterics, although the pigmentation is only in this case skin, the pigmentation is not of eschlerotics, the shade of the skin is yellow- orange and the determination of normal billirubin. The confirmation of the diagnostic is made by the quantification of carotenes which are raised (AU)
Subject(s)
Humans , Male , Female , Young Adult , Adult , Carotenoids/adverse effects , Pigmentation Disorders/diagnosis , Jaundice/diagnosis , Diagnosis, Differential , Daucus carota/adverse effectsABSTRACT
Objetivos: analizar la actividad asistencial en una unidad de Medicina Interna del Hospital Clínico Universitario de Granada. Casuística. Métodos: se estudian367 enfermos ingresados durante el años 1998 en una unidad de 18 camas. Se examinó el informe de alta o epicrisis de todos los pacientes, protocolizando la edad, sexo, diagnósticos principal y secundarios, mortalidad intrahospitalaria, traslado a otros servicios. Resultados: 202 (55%) pacientes eran varones y 165 (45%) mujeres. Hubo un neto predominio de las edades avanzadas con una media de 74±3 años. El motivo de ingreso fue por orden de frecuencia: cardiovascular respiratorio y neurológico. La mitad de los pacientes tenía 5 ó más diagnósticos al alta. La mortalidad fue del 11% (41 casos). Conclusiones: en el servicio de Medicina Interna ingresan la mayor parte de pacientes con edades muy avanzadas portadores de pluripatologías, siendo la mortalidad muy elevada
Aim: to analyse the activity in an Internal Medicine Unit in the Clinic Universitary Hospital of Granada. Patients. Methods: 367 patients was admitted in 1998 in 18 beds unit. We study the discharged report. Results: 202 (55%) men and 165 (45%) women. Many patients was very old, with a median age of 74±3 years. The main causes of hospitalization was cardiovascular, respiratory and neourologic disease. Half of patients had 5 or more diagnoses when they were discharged. Mortality was 11% (41 cases).Conclusions: most of the patients in a Internal medicine Unit was old people, with many diseases and a high mortality
Subject(s)
Humans , Male , Female , Aged , Hospitalization/statistics & numerical data , Internal Medicine/statistics & numerical data , Morbidity/trends , Hospital Departments/statistics & numerical data , Spain , Hospital Statistics , Hospital Mortality , Age Distribution , Sex DistributionABSTRACT
No disponible
Subject(s)
Middle Aged , Aged , Male , Female , Humans , Yersinia enterocolitica , Retroperitoneal Space , Bacteremia , Yersinia Infections , Anticoagulants , Biopsy , Diagnosis, Differential , Acenocoumarol , Liver Cirrhosis , Liver , Iron , HematomaABSTRACT
We describe seven patients (five females and two males) with pernicious anaemia and Sjögren's syndrome. The diagnosis of pernicious anaemia was confirmed by bone marrow aspiration and a Schilling's test. Sjögren's syndrome was diagnosed by the Schirmer-I tear test, salivary gland scintigraphy, minor salivary gland biopsy and determination of lacrimal lysozyme. We have reviewed the literature and found few cases reported of the association of these two diseases.
Subject(s)
Anemia, Pernicious/complications , Sjogren's Syndrome/complications , Aged , Aged, 80 and over , Anemia, Pernicious/diagnosis , Bone Marrow/pathology , Female , Hematopoiesis , Humans , Male , Middle Aged , Sjogren's Syndrome/diagnosisABSTRACT
We present six cases of imported malaria in Spanish and foreign patients who had visited or lived in areas of malaria endemic. Two patients presented deficit of erythrocytic glucose-6-phosphate dehydrogenase. The main aspects of these two pathologies are analyzed, stressing their similar geographic distribution and the mechanisms by which such deficit protects against the malaria infection. In addition, we describe the problems that may arise with the use of anti-malaria in carriers of this enzymatic deficit; in our patients, the use of chloroquine did not raise any problem.
