Subject(s)
Adipose Tissue/drug effects , Antineoplastic Combined Chemotherapy Protocols/adverse effects , Panniculitis/chemically induced , Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy , Adult , Cytarabine/administration & dosage , Etoposide/administration & dosage , Fat Necrosis/chemically induced , Female , Humans , Methotrexate/administration & dosage , Panniculitis/drug therapySubject(s)
Carcinoma, Signet Ring Cell/secondary , Skin Neoplasms/secondary , Stomach Neoplasms/pathology , Adult , Biopsy, Needle , Carcinoma, Signet Ring Cell/pathology , Carcinoma, Signet Ring Cell/surgery , Disease Progression , Face , Fatal Outcome , Gastrectomy/methods , Humans , Immunohistochemistry , Male , Neoplasm Staging , Skin Neoplasms/pathology , Stomach Neoplasms/surgeryABSTRACT
The aim of this study was to determine the frequency of cutaneous warts (CW) in patients with lupus erythematosus (LE) and evaluate the effect of immunosuppressants on the appearance of CW. Fifty-eight patients with LE, 74 with rheumatoid arthritis (RA), and 105 healthy individuals were interviewed and examined for the presence of CW. All were questioned to find out whether their CW developed before or after onset of the disease or during treatment. Cutaneous warts occurred considerably more often in patients with LE than in healthy control and RA patients ( P<0.003 and P<0.04, respectively). The presence of CW did not correlate with the taking of immunosuppressive drugs. The findings suggest that the high prevalence of CW in patients with LE is probably due to defects in some immune mechanisms, independently of immunosuppressive drugs.
Subject(s)
Lupus Erythematosus, Discoid/pathology , Lupus Erythematosus, Systemic/pathology , Warts/pathology , Adolescent , Adult , Aged , Child , Female , Humans , Immunosuppressive Agents/therapeutic use , Lupus Erythematosus, Discoid/complications , Lupus Erythematosus, Discoid/drug therapy , Lupus Erythematosus, Systemic/complications , Lupus Erythematosus, Systemic/drug therapy , Male , Middle Aged , Prevalence , Turkey/epidemiology , Warts/complications , Warts/epidemiologyABSTRACT
The aim of the study was to determine the chromium concentrations of soil and plant specimens taken from a rural area exposed to cement factory emissions and also to determine the blood concentrations and sensitivity conditions observed in humans residing in this rural area. The study was carried out in Cukurhisar, a town in Eskisehir-Turkey, between May 2000 and March 2001. Besides the 108 soil (36 for control) and plant specimens, which were taken from eight different directions from the cement factory, blood samples of the individuals residing in this area were taken from 258 subjects (258 for control) following a physical examination, and patch tests were also applied. The chromium concentrations of the soil and plant specimens taken from different places in different directions of the factory were higher than in the control areas. The physical examination of subjects did not reveal results different from those of the control group except for the diagnosis of contact dermatitis. The analyses of venous blood samples showed that chromium concentrations were found to be within the reference values given for both groups, but higher in the subjects (P<0.001). According to the results of patch tests, sensitivity to chromium was found to be more frequent for the subject group than the control group (P<0.05). According to these results, clinical tools revealed no toxic effects for the subjects, except contact dermatitis. However, sensitivity to patch tests showed that this subject group has been affected compared to the control group and that this effect increased with age.
