ABSTRACT
A chronic high-fat diet (HFD) produces obesity, leading to pathological consequences in the liver and skeletal muscle. The fat in the liver leads to accumulation of a large number of intrahepatic lipid droplets (LD), which are susceptible to oxidation. Obesity also affects skeletal muscle, increasing LD and producing insulin signaling impairment. Physalis peruviana L. (PP) (Solanaceae) is rich in peruvioses and has high antioxidant activity. We assessed the ability of PP to enhance insulin-dependent glucose uptake in skeletal muscle and the capacity to prevent both inflammation and lipoperoxidation in the liver of diet-induced obese mice. Male C57BL/6J mice were divided into groups and fed for eight weeks: control diet (C; 10% fat, 20% protein, 70% carbohydrates); C + PP (300 mg/kg/day); HFD (60% fat, 20% protein, 20% carbohydrates); and HFD + PP. Results suggest that PP reduces the intracellular lipoperoxidation level and the size of LD in both isolated hepatocytes and skeletal muscle fibers. PP also promotes insulin-dependent skeletal muscle glucose uptake. In conclusion, daily consumption of 300 mg/kg of fresh pulp of PP could be a novel strategy to prevent the hepatic lipoperoxidation and insulin resistance induced by obesity.
Subject(s)
Hepatitis, Animal/etiology , Hepatitis, Animal/metabolism , Insulin Resistance , Muscle, Skeletal/drug effects , Muscle, Skeletal/metabolism , Obesity/complications , Physalis/chemistry , Plant Extracts/pharmacology , Adipose Tissue/metabolism , Animals , Biomarkers , Body Weight , Diet, High-Fat , Disease Models, Animal , Fruit/chemistry , Glucose Tolerance Test , Hepatitis, Animal/pathology , Hepatitis, Animal/prevention & control , Inflammation Mediators/metabolism , Insulin/metabolism , Lipid Peroxidation/drug effects , Male , Mice , Obesity/etiology , Obesity/metabolism , Plant Extracts/chemistry , Protective Agents/chemistry , Protective Agents/pharmacologyABSTRACT
Los autores parten del saber que la descomposición de plantas acuáticas en el agua efecta sus características principales. Estudios realizados evidenciaron que la descomposición del lirio acuático modifica la calidad del agua debido a los cambios en la concentración de oxígeno disuelto, pH, Nutrientes, materia orgánica y la demanda química de oxígeno entre otros, por lo que el objetivo de este estudio fué el de conocer el comportamiento de dichos parámetros y la concentración de 2,4-D en agua, sedimentos y peces de la presa Solís, Guanajuato antes, durante y después del tratamiento
