ABSTRACT
Our method for evaluating the time course and intensity of antibiotics and other drugs transport in the predominant direction between the blood and lymph in humans promotes a more objective evaluation of drug circulation mechanisms, which is essential for determining the time of their repeated administration and route of administration. Calculation of the lymph/blood difference coefficient, based on parallel repeated measurements of the drug concentration in the lymph and blood, and of the lymph/blood coefficient provides complete data on the direction and time course of drug transport between the lymph and blood in the predominant direction.
Subject(s)
Biological Transport/physiology , Lymph/metabolism , Pharmaceutical Preparations/blood , Ampicillin/blood , Ampicillin/pharmacokinetics , Humans , Kanamycin/blood , Kanamycin/pharmacokinetics , Oleandomycin/blood , Oleandomycin/pharmacokinetics , Peritonitis/drug therapy , Tetracycline/blood , Tetracycline/pharmacokineticsABSTRACT
Scientifically grounded transfusion of lymph and its components was first used to treat 123 patients with severe surgical abnormality concurrent with secondary immunodeficiency, dysproteinemia and lipid deficiency. The treatment led to early improvement of the patients' general condition as shown up by normalized body temperatures, diminished intoxications events, reduced pus discharged from wounds, and early activation in patients. At the same time, the postoperative mortality rates decreased from 43 to 20.3%, the number of postoperative complications reduced from 18.2 to 13.4%, and their course abated. The patients' hospital stay reduced from 28.3 to 21.7 bed/days and the time of their disability dropped from 49.1 to 38.3 days.
Subject(s)
Lymph , Organ Transplantation , Postoperative Complications/prevention & control , Surgical Procedures, Operative/mortality , Convalescence , Humans , Length of StaySubject(s)
Lymphatic System/physiopathology , Peritonitis/physiopathology , Abdomen , Animals , DogsABSTRACT
The time-course of tetraolean concentrations (according to tetracycline) in the lymph, blood and urine of 10 patients with various complicated acute inflammatory diseases of the organs of the abdominal cavity was studied. It was found that tetraolean used intramuscularly in the early postoperative periods was well absorbed into the lymph, reached its maximum level within 2 hours and exceeded that in the blood. During the following 8 hours the concentration of the drug in the lymph decreased but still remained much higher than that in the blood. Lymph sorption lowered the antibiotic lymph level to 30 per cent, which indicated the necessity of an adequate increase in the drug dose.
Subject(s)
Lymph/metabolism , Oleandomycin/metabolism , Peritonitis/metabolism , Tetracycline/metabolism , Acute Disease , Adsorption , Adult , Drug Combinations , Female , Humans , Kinetics , Middle Aged , Peritonitis/complications , Peritonitis/therapyABSTRACT
Pharmacokinetics of kanamycin sulfate in the lymph, blood and urine of 12 patients with acute inflammatory diseases of the organs of the abdominal cavity was studied. The study showed that kanamycin sulfate administered intramuscularly was rapidly absorbed into the lymph and blood reaching the maximum levels within 2 hours of the administration. The therapeutic levels were preserved for at least 8 hours. The concentration of kanamycin in pure lymph by the method of lymphosorption was 20 per cent lower which was connected with the drug adsorption by the sorbents.
Subject(s)
Abdomen, Acute/metabolism , Kanamycin/metabolism , Lymph/metabolism , Abdomen, Acute/complications , Adult , Aged , Humans , Kinetics , Male , Middle Aged , Postoperative Complications/metabolism , Time FactorsABSTRACT
Lymphosorption was used in 23 patients with diffuse wound peritonitis within 4--6 days in the complex of measures in order to detoxicate the organism. It resulted, as a rule, in decreased ammonemia, normalized residual nitrogen and urea and in the disappearance of erythrocytes from the lymph. Eighteen patients recovered, 5 patients died of progressing peritonitis and hepatic insufficiency.
Subject(s)
Abdominal Injuries/surgery , Lymph/physiology , Peritonitis/surgery , Absorption , Adult , Drainage/methods , Humans , Male , Thoracic Duct/surgery , Wounds, Nonpenetrating/surgery , Wounds, Penetrating/surgeryABSTRACT
Ampicillin levels in the lymph, blood and urine were studied in 15 patients with various inflammatory diseases of the organs of the abdominal cavity. It was found that ampicillin administered intramuscularly to such patients at early postoperative periods was well absorbed not only to the blood but also to the lymph, reaching in parallel its maximum levels in an hour. After that the drug concentration in the lymph persisted for 6 hours and markedly exceeded that in the blood. Adsorption of the lymph lowered the antibiotic concentration in it to 25 per cent indicating the necessity for increasing the drug therapeutic doses.