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Sci Rep ; 14(1): 10985, 2024 05 14.
Article in English | MEDLINE | ID: mdl-38744979

ABSTRACT

Several prognostic factors are known to influence survival for patients treated with IDH-wildtype glioblastoma, but unknown factors may remain. We aimed to investigate the prognostic implications of early postoperative MRI findings. A total of 187 glioblastoma patients treated with standard therapy were consecutively included. Patients either underwent a biopsy or surgery followed by an early postoperative MRI. Progression-free survival (PFS) and overall survival (OS) were analysed for known prognostic factors and MRI-derived candidate factors: resection status as defined by the response assessment in neuro-oncology (RANO)-working group (no contrast-enhancing residual tumour, non-measurable contrast-enhancing residual tumour, or measurable contrast-enhancing residual tumour) with biopsy as reference, contrast enhancement patterns (no enhancement, thin linear, thick linear, diffuse, nodular), and the presence of distant tumours. In the multivariate analysis, patients with no contrast-enhancing residual tumour or non-measurable contrast-enhancing residual tumour on the early postoperative MRI displayed a significantly improved progression-free survival compared with patients receiving only a biopsy. Only patients with non-measurable contrast-enhancing residual tumour showed improved overall survival in the multivariate analysis. Contrast enhancement patterns were not associated with survival. The presence of distant tumours was significantly associated with both poor progression-free survival and overall survival and should be considered incorporated into prognostic models.


Subject(s)
Brain Neoplasms , Glioblastoma , Magnetic Resonance Imaging , Humans , Glioblastoma/diagnostic imaging , Glioblastoma/surgery , Glioblastoma/mortality , Glioblastoma/pathology , Glioblastoma/therapy , Magnetic Resonance Imaging/methods , Female , Male , Middle Aged , Prognosis , Aged , Brain Neoplasms/diagnostic imaging , Brain Neoplasms/surgery , Brain Neoplasms/pathology , Brain Neoplasms/mortality , Adult , Neoplasm, Residual/diagnostic imaging , Postoperative Period , Progression-Free Survival
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