Methods and initial findings of the Observational Study of Ostomy Consumers Registry.

BACKGROUND: Longitudinal patient-reported data are limited for people living with an ostomy. PURPOSE: The Observational Study of Ostomy Consumers (OSO) registry collects data from individuals living with an ostomy. METHODS: Self-reported data were collected via repeated electronic surveys completed by adults living with an ostomy in the United States (US) and United Kingdom (UK). RESULTS: Baseline data, collected between October 2018 and February 2021, were available for 299 individuals from the US (77.9%) and UK (22.1%). Most participants reported using a 2-piece pouching system (55.5%) rather than a 1-piece system (44.4%), and using a convex barrier (54.4%) or flat barrier (44.3%). The most commonly reported barrier wear times were ≥ 3 to < 4 days for 36.6% of participants in the US and ≥ 1 to < 2 days for 42.4% of participants in the UK. Despite self-reports of leakage and peristomal skin conditions, quality of life remained positive. A majority of participants (92.0%) reported being very satisfied or somewhat satisfied with their ostomy product. CONCLUSION: The Observational Study of Ostomy Consumers registry allows for a continuous data stream that can be mined to help understand the patient experience over time. Understanding patient experiences will help to inform clinical practice and research, health care utilization, and product innovation.

The association between diet and physical activity on insulin resistance in the Women's Interagency HIV Study.

OBJECTIVES: To evaluate the association of diet and physical activity with insulin resistance (IR) in HIV-infected and HIV-uninfected women. METHODS: Cross-sectional analyses of summary dietary measures and physical activity intensity scores obtained from women enrolled in the San Francisco (n = 113) and Chicago (n = 65) Women's Interagency HIV Study (WIHS) sites. IR was estimated using the homeostasis model assessment (HOMA-IR). Stepwise regression models assessed the association of diet and physical activity with HOMA-IR after adjustment for demographic, behavioral, and clinical factors. RESULTS: Compared with HIV-uninfected women, HIV-infected women were older and more likely to have health insurance. In multivariable analysis including all women, being from San Francisco ( P = 0.005), having a higher mean body mass index (BMI, P < 0.001), and having a higher percent kilocalories from sweets (P = 0.025) were associated with greater HOMA-IR; heavy intensity physical activity (P = 0.006) and annual household income more than $36,000 ( P = 0.02) was associated with a lower HOMA-IR. In analysis limited to HIV-infected women, having a higher body mass index (P < 0.001) and a history of protease inhibitor use (P = 0.002) were significantly associated with higher HOMA-IR; heavy intensity activity (P = 0.06) was marginally associated with lower HOMA-IR and being menopausal (P = 0.05) was marginally associated with higher HOMA-IR. CONCLUSIONS: Among urban women with or at risk for HIV-infection, heavy intensity physical activity was associated with lower HOMA-IR, whereas higher percent kilocalories from sweets were associated with higher HOMA-IR. Given the overall health benefits of physical activity and a diet low on sugar, these behaviors should be encouraged whenever possible.