ABSTRACT
The aim of the work - to determine the pathogenetic role of carbohydrate malabsorption syndrome in severity and duration of rotavirus infection symptoms in early aged children. The study included 60 breastfed children aged 1-24 months with rotavirus infection. The severity and duration of the main symptoms of rotavirus gastroenteritis were analyzed depending on the dynamic changes in laboratory parameters of carbohydrate malabsorption syndrome: the total amount of reducing carbohydrates in feces, lactose and glucose in feces, which were determined on II-III, V, VII and X days of the disease. To determine the total amount of reducing sugars in the coprofiltrates, the Benedict's test was used, the lactose in the feces was determined using the Malfatti's test, and the glucose was determined by the Glucophane test systems (Erba Lachema). It was found that the syndrome of carbohydrate malabsorption had the maximum pathogenetic effect on the severity of rotavirus diarrhea after the fifth day of the disease mainly due to lactase deficiency. Starting from the seventh day of rotavirus infection, with an increase in the level of carbohydrates in the feces by 0,5%, the frequency of liquid stools increases by 1 time per day. The prognostic sign of long-term diarrheal syndrome (≥9 days) is the total level of reducing sugars in the feces ≥1% on the fifth day of illness. If the result of the Benedict's test increases by 0,4% in this term, the duration of diarrhea increases by 1 day. When the level of carbohydrates in the stool ≥ 0,75% on the tenth day of the disease the risk of residual effects on discharge from the hospital (such as unstable stools 2-3 times a day, meteorism and flatulence) increases.
Subject(s)
Diarrhea, Infantile , Malabsorption Syndromes , Rotavirus Infections , Rotavirus , Adolescent , Adult , Aged , Carbohydrates , Child , Child, Preschool , Diarrhea/diagnosis , Diarrhea/epidemiology , Feces , Female , Humans , Infant , Malabsorption Syndromes/complications , Malabsorption Syndromes/diagnosis , Rotavirus Infections/complications , Rotavirus Infections/diagnosis , Young AdultABSTRACT
The aim of the present study was to analyze clinical and cytokine features of recurrent respiratory system diseases in children with toxocariasis. 50 children aged 1 to 17 years (mean age - 10±5 years) with recurrent current of respiratory system disorders were studied. During the survey such clinical manifestations of the respiratory system disorders as obstructive bronchitis (50%), bronchial asthma (30%), pneumonia (10%) and laryngotracheitis (10%) have been revealed. Statistical analysis of the results was performed using the software package STATISTICA 6.1 (SNANSOFT). We have shown that the disorders of respiratory system in case of toxocariasis invasion often occur with severe intoxication and bronchial obstruction syndromes, temperature reaction, respiratory insufficiency and hepatomegaly. A prolonged course of the disease has been noted. "Inflammatory" indicators of general blood analysis, such as leukocytosis and increased of ESR have been recorded in patients with respiratory system disorders in children with T.canis infection significantly more often, significant "allergic" laboratory changes were in the form of eosinophilia. High average levels of pro-inflammatory IL-6, as well as low levels of IL 5 have been determined in children suffering from the respiratory system disorders and with toxocariasis invasion in the anamnesis. The obtained findings require further study.
