ABSTRACT
Results of comparative studying of influence of low-molecular weight heparin clexane (enoxaparine sodium) and nonfractionized heparin on coagulational properties of blood in patients with uncomplicated urosepsis are presented. It was established that application of clexane promotes an effective prophylaxis of thromboembolic complications without rising of the hemorrhage occurrence risk.
Subject(s)
Anticoagulants/therapeutic use , Enoxaparin/therapeutic use , Sepsis/drug therapy , Urologic Diseases/drug therapy , Female , Humans , Male , Middle AgedSubject(s)
Blood Transfusion , Brain Injuries/therapy , Acute Disease , Adult , Brain Injuries/physiopathology , Follow-Up Studies , Hemodynamics , Humans , Male , Time FactorsABSTRACT
Biogenic amine metabolism in severe brain trauma has been analysed in 165 patients whose brain was protected from hypoxia with GOBA and thiobarbiturates in subnarcotic doses (116 cases) and the combination of the above agents with an early course of HBO (49 cases). The peculiarities of biogenic amine metabolism have been established in patients recovered and those who died later. As any activation of biogenic amine systems realizing stress enhances disadaptation processes, it is recommended to begin a course of HBO upon their stabilization.
Subject(s)
Biogenic Amines/metabolism , Brain Injuries/metabolism , Hypoxia, Brain/prevention & control , Adolescent , Adult , Brain Injuries/complications , Brain Injuries/therapy , Combined Modality Therapy , Humans , Hyperbaric Oxygenation , Hypoxia, Brain/etiology , Middle AgedSubject(s)
Career Choice , Students, Medical , Humans , Methods , School Admission Criteria , Schools, Medical , UkraineABSTRACT
Adaptation and disadaptation processes predetermining the outcome of treatment have been revealed upon the analysis of adaptation mechanisms formed in 49 patients with severe craniocerebral trauma in conditions of brain protection from hypoxia achieved by combined bolus injection of subnarcotic doses of sodium hydroxybutyrate and sodium thiopental and an early course of hyperbaric oxygenation (HBO). As the activation of biogenic amine systems responsible for stress promotes the enhancement of disadaptation processes, it is recommended to start a course of HBO upon their stabilization. The nature of lactate and pyruvate level changes in the in- and outflowing blood enabled the authors to identify the presence of negative arteriovenous difference in pyruvate upon the first attempt of HBO session as an adaptation marker and biochemical criterion showing the advisability of an HBO course.
Subject(s)
Adaptation, Physiological , Brain Injuries/therapy , Hyperbaric Oxygenation , Adolescent , Adult , Brain Injuries/physiopathology , Drug Therapy, Combination , Humans , Hydroxybutyrates/administration & dosage , Middle Aged , Thiopental/administration & dosageSubject(s)
Schools, Medical/history , Women/history , Female , History, 20th Century , Humans , UkraineABSTRACT
From analysis of the adaptation mechanisms forming in severe brain trauma in 49 patients during its protection from hypoxia by combined administration of subnarcotic doses of sodium oxybutyrate and sodium thiopental in a bolus and an early course of hyperbaric oxygenation (HBO) the authors revealed the adaptation and disadaptation processes determining the outcome of the treatment. Since activation of the system of stress realizing biogenic amines promotes disadaptation processes, whatever the outcome, it is recommended to begin HBO after their stabilization. The character of changes of the lactate and pyruvate levels in blood flowing to and from the brain allowed the authors to distinguish the occurrence of a negative A-B gradient according to pyruvate after the first trial HBO session as a market of adaptation and a biochemical criterion of the expediency of prescribing a course of HBO.
Subject(s)
Adaptation, Physiological/drug effects , Brain Injuries/physiopathology , Hyperbaric Oxygenation , Hypoxia, Brain/prevention & control , Acute Disease , Adolescent , Adult , Brain Injuries/mortality , Brain Injuries/therapy , Combined Modality Therapy , Consciousness Disorders/mortality , Consciousness Disorders/physiopathology , Consciousness Disorders/therapy , Critical Care , Humans , Hypoxia, Brain/mortality , Hypoxia, Brain/physiopathology , Middle Aged , Time FactorsSubject(s)
Antipsychotic Agents/therapeutic use , Biogenic Amines/metabolism , Brain Injuries/therapy , Hydroxybutyrates/therapeutic use , Hypoxia, Brain/prevention & control , Sodium Oxybate/therapeutic use , Thiopental/therapeutic use , Acute Disease , Adult , Female , Humans , Male , Middle Aged , PhenothiazinesABSTRACT
Rocket-linear immunoelectrophoresis enabled to estimate the alpha-fetoprotein content in blood serum of pregnant women. Sensitivity of the procedure constituted as low as 13-22 ng of the protein per I ml of blood serum. Concentration of the protein in blood serum depended on the period of pregnancy; middle values of normal content of alpha-fetoprotein in blood serum were estimated within various periods of pregnancy in women of the district studied. The procedure might be used simultaneously with immunoenzymatic and radioimmune methods in prenatal diagnosis of impairments in development of the fetus neural tube.
