Influence of Pulsatility and Inflow Waveforms on Tracheal Airflow Dynamics in Healthy Older Adults.

Tracheal collapsibility is a dynamic process altering local airflow dynamics. Patient-specific simulation is a powerful technique to explore the physiological and pathological characteristics of human airways. One of the key considerations in implementing airway computations is choosing the right inlet boundary conditions that can act as a surrogate model for understanding realistic airflow simulations. To this end, we numerically examine airflow patterns under the influence of different profiles, i.e., flat, parabolic, and Womersley, and compare these with a realistic inlet obtained from experiments. Simulations are performed in ten patient-specific cases with normal and rapid breathing rates during the inhalation phase of the respiration cycle. At normal breathing, velocity and vorticity contours reveal primary flow structures on the sagittal plane that impart strength to cross-plane vortices. Rapid breathing, however, encounters small recirculation zones. Quantitative flow metrics are evaluated using time-averaged wall shear stress (TAWSS) and oscillatory shear index (OSI). Overall, the flow metrics encountered in a real velocity profile are in close agreement with parabolic and Womersley profiles for normal conditions, however, the Womersley inlet alone conforms to a realistic profile under rapid breathing conditions.

Quantifying hemodynamics within an aneurysm exposed to prolonged exercise levels.

BACKGROUND AND OBJECTIVE: Non-invasive treatment of unruptured Abdominal Aortic Aneurysm involves subjecting the patients to certain physiological levels of the heart. Flow topology (Repeak = 200-1200, frequency: f = 1.18-2.41 Hz) within an aneurysm geometry (2-D) under resting and exercise (mild and moderate) conditions are explored in the present study. Blood is assumed to be Newtonian in nature. Spatio-temporal evolution of the flow patterns and vorticity are established. Hemodynamic indicators (TAWSS and OSI), movement of vortex cores and Particle Residence Index (PRI) are quantified to select an optimum exercise level in attenuating the disease. METHODS: The finite volume method is employed for numerical solutions using ANSYS-FluentⓇ software. The SIMPLE scheme has been used for the pressure-velocity coupling. Least Square cell-based method is used for the spatial discretization of the gradients. Second order upwind scheme is considered for discretization of the pressure term. Third order upwind (QUICK) scheme is used to discretize the momentum equation. First order Implicit Scheme was used for the discretization of the temporal terms. Discrete Phase Material (DPM) technique is employed throughout, to visualize the signature of particle deposits within the aneurysm. RESULTS: Vortex impingement induces a pressure peak within the aneurysm (moderate) while the peaks are anchored at the proximal and distal ends under resting and mild conditions. Along the averaged flow separation zone, exercise increases the maximum TAWSS from 1.21 N/m2 (mild) to 9.3 N/m2 (moderate). The distal site is exposed to oscillatory loading (OSI = 0.5) under mild activity whereas the loading becomes distributed almost over the entire wall, when subjected to moderate conditions. This in turn, reduces the time involved in 50 percent clearance of particles (PRI = 0.5) from 10.56 s (resting) to 3.98 s (mild) and 0.87 s (moderate), respectively. CONCLUSIONS: Resting conditions manifests the aneurysmal wall to recirculating fluid for most of cycle time. Moderate exercise exhibits the least particle clearance time, but it exposes the aneurysmal wall and the distal end to high pressure, which otherwise has low intensity under mild activity. This in turn establishes that mild exercise for prolonged duration can be an optimum level for non-invasive aneurysmal treatment.