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1.
Clin. transl. oncol. (Print) ; 23(8): 1585-1592, ago. 2021. graf
Article in English | IBECS | ID: ibc-222157

ABSTRACT

Purpose This study aimed to determine the outcomes and prognostic factors associated with octogenarians who underwent pulmonary resection for lung cancer. Methods/patients From 2009 to 2018, 76 octogenarians underwent pulmonary surgery for lung cancer at the Kanazawa Medical University, Japan. They were divided into two groups (early and late octogenarians), and their clinicopathological characteristics and outcomes were investigated. Overall survival rates and recurrence-free survival rates were determined using Kaplan–Meier curves. Univariate and multivariate analyses were performed to identify prognostic factors. Results Limited surgery was performed more often in the late octogenarian group; however, most perioperative factors were not significantly different between the two groups. The 3-year overall survival and recurrence-free survival rates were 61.2% and 52.8%, respectively. The median observation period was 37.5 (8.9–112.3) months postoperatively. Kaplan–Meier curves showed that age ≥ 85 years (late octogenarian), smoking history, and squamous cell carcinoma on histology were associated with worse survival rates. Multivariate analysis identified age ≥ 85 years (late octogenarian) (p = 0.011) and cigarette smoking (p = 0.025) as unfavorable prognostic factors for overall survival and recurrence-free survival, respectively. Conclusions Most octogenarians with an indication for surgery can tolerate pulmonary surgery. However, owing to the limitations of this retrospective, single-center study, future studies involving multiple-institutions are required to confirm our findings (AU)


Subject(s)
Humans , Carcinoma, Squamous Cell/surgery , Lung Neoplasms/surgery , Thoracic Surgery, Video-Assisted , Prognosis , Retrospective Studies , Carcinoma, Squamous Cell/mortality , Lung Neoplasms/mortality , Treatment Outcome , Kaplan-Meier Estimate , Age Factors
2.
Clin Transl Oncol ; 23(8): 1585-1592, 2021 Aug.
Article in English | MEDLINE | ID: mdl-33502740

ABSTRACT

PURPOSE: This study aimed to determine the outcomes and prognostic factors associated with octogenarians who underwent pulmonary resection for lung cancer. METHODS/PATIENTS: From 2009 to 2018, 76 octogenarians underwent pulmonary surgery for lung cancer at the Kanazawa Medical University, Japan. They were divided into two groups (early and late octogenarians), and their clinicopathological characteristics and outcomes were investigated. Overall survival rates and recurrence-free survival rates were determined using Kaplan-Meier curves. Univariate and multivariate analyses were performed to identify prognostic factors. RESULTS: Limited surgery was performed more often in the late octogenarian group; however, most perioperative factors were not significantly different between the two groups. The 3-year overall survival and recurrence-free survival rates were 61.2% and 52.8%, respectively. The median observation period was 37.5 (8.9-112.3) months postoperatively. Kaplan-Meier curves showed that age ≥ 85 years (late octogenarian), smoking history, and squamous cell carcinoma on histology were associated with worse survival rates. Multivariate analysis identified age ≥ 85 years (late octogenarian) (p = 0.011) and cigarette smoking (p = 0.025) as unfavorable prognostic factors for overall survival and recurrence-free survival, respectively. CONCLUSIONS: Most octogenarians with an indication for surgery can tolerate pulmonary surgery. However, owing to the limitations of this retrospective, single-center study, future studies involving multiple-institutions are required to confirm our findings.


Subject(s)
Carcinoma, Squamous Cell/surgery , Lung Neoplasms/surgery , Lung/surgery , Age Factors , Aged, 80 and over , Analysis of Variance , Carcinoma, Squamous Cell/mortality , Female , Humans , Japan , Kaplan-Meier Estimate , Lung Neoplasms/mortality , Male , Prognosis , Progression-Free Survival , Retrospective Studies , Smoking/adverse effects , Survival Rate , Thoracic Surgery, Video-Assisted , Treatment Outcome
3.
Oncogene ; 35(22): 2893-901, 2016 06 02.
Article in English | MEDLINE | ID: mdl-26411364

ABSTRACT

In mouse mammary epithelial cells, cytoplasmic polyadenylation element binding protein 1 (CPEB1) mediates the apical localization of ZO-1 mRNA, which encodes a critical tight junction component. In mice lacking CPEB1 and in cultured cells from which CPEB has been depleted, randomly distributed ZO-1 mRNA leads to the loss of cell polarity. We have investigated whether this diminution of polarity results in an epithelial-to-mesenchyme (EMT) transition and possible increased metastatic potential. Here, we show that CPEB1-depleted mammary epithelial cells alter their gene expression profile in a manner consistent with an EMT and also become motile, which are made particularly robust when cells are treated with transforming growth factor-ß, an enhancer of EMT. CPEB1-depleted mammary cells become metastatic to the lung following injection into mouse fat pads while ectopically expressed CPEB1 prevents metastasis. Surprisingly, CPEB1 depletion causes some EMT/metastasis-related mRNAs to have shorter poly(A) tails while other mRNAs to have longer poly(A) tails. Matrix metalloproteinase 9 (MMP9) mRNA, which encodes a metastasis-promoting factor, undergoes poly(A) lengthening and enhanced translation upon CPEB reduction. Moreover, in human breast cancer cells that become progressively more metastatic, CPEB1 is reduced while MMP9 becomes more abundant. These data suggest that at least in part, CPEB1 regulation of MMP9 mRNA expression mediates metastasis of breast cancer cells.


Subject(s)
Breast Neoplasms/pathology , Epithelial-Mesenchymal Transition , Transcription Factors/metabolism , mRNA Cleavage and Polyadenylation Factors/metabolism , Animals , Cell Line, Tumor , Cell Movement/drug effects , Epithelial-Mesenchymal Transition/drug effects , Female , Humans , Mammary Glands, Animal/drug effects , Mammary Glands, Animal/pathology , Matrix Metalloproteinase 9/genetics , Mice , Neoplasm Metastasis , Poly A/genetics , Poly A/metabolism , RNA, Messenger/genetics , RNA, Messenger/metabolism , Transforming Growth Factor beta/pharmacology
4.
Kyobu Geka ; 62(12): 1073-7, 2009 Nov.
Article in Japanese | MEDLINE | ID: mdl-19894574

ABSTRACT

We treated of 3 patients with descending necrotizing mediastinitis that is often to be fatal. There are 3 important issues regarding the treatment of this disease. First, the precise sites of abscess should be determined by computed tomography (CT) scans from the neck to diaphragm. Second, effective drainage of the neck and mediastinal abscess should be carried out immediately when the sites of abscess are determined. Third, drainage under video-assisted thoracic surgery (VATS) is an appropriate treatment because VATS is less invasive and provides an easier placement of the drainage tubes at abscess sites.


Subject(s)
Mediastinitis/surgery , Aged , Female , Humans , Male , Mediastinitis/diagnostic imaging , Middle Aged , Necrosis , Radiography
5.
Kyobu Geka ; 62(7): 545-51, 2009 Jul.
Article in Japanese | MEDLINE | ID: mdl-19588824

ABSTRACT

A mediastinal nonseminomatous germ cell tumor was completely resected after down-staging by chemotherapy despite the presence of multiple distant metastases. A 22-year-old female was admitted for superior vena cava (SVC) syndrome. Her SVC was obstructed by a large anterior mediastinal tumor; she also exhibited distant metastases on a left rib, in the liver, and multiple in the lung. The blood alpha-fetoprotein (AFP) level was extremely elevated to 57,530 ng/ml. Four courses of BEP therapy [cisplatin (CDDP), bleomycin (BLM), etoposide (VP-16)] and a high dose chemotherapy followed by a peripheral blood stem cell transplantation made the tumor become smaller and effected its down-staging. Residual mediastinal tumor with an intravascular tumor in SVC was completely resected. The SVC was reconstructed by an artificial vessel graft. A mediastinal nonseminomatous germ cell tumor, even though it has multiple distant metastases, can achieve down-staging and complete resection by a chemotherapy based on scientific evidence.


Subject(s)
Mediastinal Neoplasms/surgery , Neoplasms, Germ Cell and Embryonal/surgery , Combined Modality Therapy , Female , Humans , Mediastinal Neoplasms/drug therapy , Neoplasm Metastasis , Neoplasms, Germ Cell and Embryonal/drug therapy , Young Adult
6.
Kyobu Geka ; 61(12): 1035-8, 2008 Nov.
Article in Japanese | MEDLINE | ID: mdl-19048903

ABSTRACT

Myxomas are account for approximately half of primary cardiac tumors, and 75% cases originate in left atrium. We report our experience of a right atrial myxoma. A 68-year-old woman was referred to us due to anorexia, general fatigue and facial edema. Echocardiogram, computed tomography (CT), magnetic resonance imaging (MRI), and catheter angiocardiogram revealed a huge tumor in right atrium. The tumor was resected completely with the attached right atrial free wall under cardiopulmonary bypass. Pathological examination showed myxomatous tissue. Postoperative course was uneventful. She discharged the hospital on the 37th day after the operation, and is now doing well without any symptoms.


Subject(s)
Heart Neoplasms/surgery , Myxoma/surgery , Aged , Cardiopulmonary Bypass , Female , Heart Atria , Humans
7.
Kyobu Geka ; 61(2): 102-8, 2008 Feb.
Article in Japanese | MEDLINE | ID: mdl-18268944

ABSTRACT

OBJECTIVE: We report herein the comparison of the virtual bronchoscopy (VB) images which were constructed with 2 different computed tomography (CT) scanners combined with 3 different applications in 2 healthy adult volunteers. METHODS: CT scanners were multi-detector row CT (MDCT) [64 detectors] and MDCT (16 detectors). Applications, by which VB images were made, were Leonardo (Leo), Ziostation (Zio), and Plus XNVZ2 (Plus). The image quality was evaluated by 3 expert bronchoscopists. RESULTS: The change of the threshold value was necessary in Leo for practical use in subsegmental bronchi and more distal area, but unnecessary in Plus or Zio. When Plus was used, the VB images from the data obtained with MDCT (16 detectors) and MDCT (64 detectors) had almost equal quality. CONCLUSIONS: Although the process to construct VB images was different in each application, it was regarded that Plus was not inferior to Zio or Leo in VB image quality.


Subject(s)
Bronchoscopy/methods , Tomography, Spiral Computed/methods , Humans
8.
Kyobu Geka ; 61(1): 51-4, 2008 Jan.
Article in Japanese | MEDLINE | ID: mdl-18186274

ABSTRACT

Lung cancer is the leading cause of cancer deaths in Japan. Recently, big progress in the treatment of lung cancer has been achieved, such as new anti-cancer drugs, molecular targeted therapy, stereotactic radiotherapy, etc. Multidisciplinary approach has been required to the therapy for lung cancer patients. In this paper, we introduce The 21st Century Multidisciplinary Center in Kanazawa Medical University, and the Hokuriku Training Program for Making Specialists in Cancer Treatment.


Subject(s)
Lung Neoplasms/therapy , Combined Modality Therapy , Humans , Japan
9.
Histol Histopathol ; 22(4): 389-97, 2007 04.
Article in English | MEDLINE | ID: mdl-17290349

ABSTRACT

Microencephaly and microphthalmia in the embryos/fetuses from rats exposed to busulfan were histopathologically examined. Busulfan was intraperitoneally administered at 10 mg/kg on gestation days (Days) 12, 13 and 14, and then embryos/fetuses were harvested on Days 14.5, 15, 16 and 21. In the treated group on Day 21, all fetuses were small with reduced body weight, with microencephaly and microphthalmia. On Days 14.5, 15 and 16, apoptotic cells were increased in the neuroepithelium and the neural retina with a width reduction and a decrease in cell density, and the lens epithelial cells histopathologically. Mitotic inhibition was observed in the neuroepithelium, neural retina and equatorial zone of the lens. On Day 21, the cerebral cortex and the retina became markedly thinner. The lens fibers showed swollen, fragmentary and vacuolar formation in the cranial portion accompanied with small lens sizes. The anti-proliferative effects of busulfan brings about a lack of cell populations required for the normal organogenesis of the brain and eye, and leads to microencephaly and microphthalmia, featuring hypoplasia of cerebrum and hypoplasia of retina and lens with cataract, respectively.


Subject(s)
Abnormalities, Drug-Induced/pathology , Antineoplastic Agents, Alkylating/toxicity , Busulfan/toxicity , Microcephaly/pathology , Microphthalmos/pathology , Teratogens/toxicity , Animals , Apoptosis/drug effects , Cell Count , Female , Injections, Intraperitoneal , Lens, Crystalline/drug effects , Lens, Crystalline/embryology , Lens, Crystalline/pathology , Microcephaly/chemically induced , Microcephaly/embryology , Microphthalmos/chemically induced , Microphthalmos/embryology , Mitosis/drug effects , Neuroepithelial Cells/drug effects , Neuroepithelial Cells/ultrastructure , Pregnancy , Rats , Rats, Wistar , Retinal Ganglion Cells/drug effects , Retinal Ganglion Cells/pathology , Specific Pathogen-Free Organisms
10.
Kyobu Geka ; 59(6): 487-90, 2006 Jun.
Article in Japanese | MEDLINE | ID: mdl-16780070

ABSTRACT

A 71-year-old woman was found to have an abnormal shadow on a chest X-ray. Fifteen years earlier she had undergone a subtotal thyroidectomy for thyroid cancer without any lymph node metastasis. Chest computed tomography (CT) revealed a mediastinal tumor with full of blood stream. Since the positron emission tomography (PET) disclosed an increased uptake of fluoro-2-deoxy-D-glucose (FDG) in the tumor, a malignant lymphatic tumor was therefore suspected. An immunohistological examination of biopsy specimens taken by thoracoscopic procedure demonstrated tumor to be lymph node metastasis of the previous thyroid cancer. After a tumor resection by means of a thoracotomy and total thyroidectomy, the patient was scheduled to receive radioiodine therapy. The previously reported cases are also herein reviewed.


Subject(s)
Carcinoma, Papillary/secondary , Lymph Nodes/pathology , Lymphatic Metastasis/diagnostic imaging , Thyroid Neoplasms/pathology , Thyroidectomy , Aged , Carcinoma, Papillary/surgery , Female , Fluorodeoxyglucose F18 , Humans , Lymph Node Excision , Lymphatic Metastasis/pathology , Mediastinum , Nuclear Proteins/analysis , Positron-Emission Tomography , Postoperative Period , Thyroid Neoplasms/surgery , Thyroid Nuclear Factor 1 , Transcription Factors/analysis
12.
Kyobu Geka ; 56(7): 597-601, 2003 Jul.
Article in Japanese | MEDLINE | ID: mdl-12854472

ABSTRACT

It has been known that treatments of post-pneumonectomy empyema are difficult. We report a successful case of irrigation for the post-pneumonectomy. The patient was 68-year-old man with advanced lung cancer. He underwent induction chemoradiotherapy following by pneumonectomy of the right side. A few days later after the chest drain was withdrawn, spike fever appeared. Empyema was suspected, so a 28 Fr diameter double lumen chest drain was intubated again. Turbid effusion was discharged through the drain, in which methicillin-resistant staphylococcus aureus (MRSA) was cultured. Irrigation using a lot of saline and acid electrolyzed water started. A month later, irrigator through the drain was looking clear, however, MRSA was cultured so far. After putting minomycine into the irrigator, MRSA died away. This physical and chemical irrigations were effective.


Subject(s)
Empyema, Pleural/therapy , Methicillin Resistance , Pneumonectomy , Postoperative Complications/therapy , Staphylococcal Infections/therapy , Adenocarcinoma/surgery , Aged , Empyema, Pleural/etiology , Humans , Lung Neoplasms/surgery , Male , Minocycline/administration & dosage , Therapeutic Irrigation
13.
Phytomedicine ; 9(3): 195-201, 2002 Apr.
Article in English | MEDLINE | ID: mdl-12046858

ABSTRACT

Two published case reports described palliation of disease after Seihai-to therapy for refractory aspiration pneumonia caused by recurrent laryngeal nerve paralysis and cerebrovascular disease. We undertook an open-label trial in patients with relapsing aspiration pneumonia. Fifteen patients with relapsing aspiration pneumonia were randomly divided into conventional therapy group (n = 8) or Seihai-to group (n = 7). In Seihai-to group, patients were treated with Seihai-to in addition to conventional therapy (Western medicines). Frequency of feverish days and antibiotics-use, CRP value and chest CT or X-ray findings were compared between the two groups during the study period of 16 weeks. In the Seihai-to group, the latency of swallowing reflex was measured in 6 patients before and after administration of Seihai-to. The mean values of fever index, CRP value and antibiotics-use in the Seihai-to group were decreased significantly, compared with those of the conventional therapy group. However, the latency of the swallowing reflex after 4 weeks of treatment was not significantly changed (p = 0.249), compared with the latency before administration of Seihai-to. No adverse reaction was observed in either group. Seihai-to was effective in reducing relapse of aspiration pneumonia in this small group. Seihai-to might not improve the swallowing reflex, but might instead improve a defense mechanism or excessive inflammation caused by pneumonia in the lower airway. Further evaluation of Seihai-to therapy for patients with aspiration pneumonia in a larger population is warranted.


Subject(s)
Drugs, Chinese Herbal/therapeutic use , Phytotherapy , Pneumonia, Aspiration/drug therapy , Aged , Aged, 80 and over , Deglutition/physiology , Drugs, Chinese Herbal/administration & dosage , Female , Humans , Inpatients , Male , Medicine, Kampo , Palliative Care , Pilot Projects , Pneumonia, Aspiration/diagnostic imaging , Pneumonia, Aspiration/pathology , Prospective Studies , Recurrence , Reflex/physiology , Tomography, X-Ray Computed , Treatment Outcome
14.
Minerva Pediatr ; 54(1): 53-6, 2002 Feb.
Article in English | MEDLINE | ID: mdl-11862166

ABSTRACT

A surgical treatment of ventricular tachycardia (VT) that induced a congenital left ventricular aneurysm (LVA) in a 12-year-old boy was performed. The VT disappeared after epicardial cryoablation and a reinforcement of LVA with a composite patch. Epicardial cryoablation, based on an intraoperative electrophysiologic study (EPS), is effective in treating VT resistant to antiarrhythmia drugs.


Subject(s)
Coronary Aneurysm/etiology , Tachycardia, Ventricular/complications , Tachycardia, Ventricular/surgery , Ventricular Dysfunction, Left/etiology , Catheter Ablation/methods , Child , Humans , Male
15.
Kyobu Geka ; 54(12): 1011-5, 2001 Nov.
Article in Japanese | MEDLINE | ID: mdl-11712369

ABSTRACT

A 55-year-old man consulted our hospital because of short of breath. Chest CT showed low attenuation areas and we diagnosed his illness as a chronic respiratory failure by chronic lung empysema. He was perfomed bilateral lung volume reduction surgery (VRS), after a few days who was in serious acute respiratory failure. He was treated by non-invasive positive pressure ventilation (NIPPV) for those. After that general condition and arterial blood gas data was improved. NIPPV may be one of the effective tools for acute respiratory failure after VRS.


Subject(s)
Pneumonectomy , Positive-Pressure Respiration , Postoperative Complications/therapy , Pulmonary Emphysema/surgery , Respiratory Insufficiency/therapy , Acute Disease , Chronic Disease , Humans , Male , Middle Aged , Severity of Illness Index , Treatment Outcome
16.
Cancer ; 92(3): 588-94, 2001 Aug 01.
Article in English | MEDLINE | ID: mdl-11505403

ABSTRACT

BACKGROUND: In Miyagi Prefecture, Japan, a mass screening program for lung cancer has been conducted since 1982 (miniature chest X-ray for all screenees and sputum cytology for those with a smoking index > or = 600) [smoking index 600 = 30 pack years, the average number of cigarettes smoked per day multiplied by the number of years of regular smoking]. Over 1500 lung carcinomas, including 250 roentgenographically occult lung tumors, were detected and treated up to 1999. In the current study, a nested case-control study was conducted in the population that was screened in 1989 to evaluate the efficacy of the screening program for lung cancer. METHODS: To reduce self-selection bias, the source population was defined as screenees with negative results in 1989 (284,226 individuals). In the population, 474 individuals died of lung carcinoma during 1992-1994. After exclusion, 328 patients who died of primary lung carcinoma at between ages 40 years and 79 years were defined as the cases. Six controls were supposed to be selected in the source population for each case and matched by gender, year of birth, municipality, and smoking habits. Controls who had died or moved before the matched case was diagnosed were excluded. Finally, 328 cases and 1886 controls were selected. Screening histories were compared, and odds ratios were calculated using conditional logistic regression analysis. RESULTS: Within the 12 months before diagnosis, 241 of 328 cases (73.5%) had attended the screening compared with 1557 of 1886 controls (82.6%). The smoking-adjusted odds ratio was 0.54 (95% confidence interval, 0.41-0.73). CONCLUSIONS: The mass screening program for lung cancer in Miyagi Prefecture was capable of reducing by 46% the risk of death from carcinoma of the lung.


Subject(s)
Lung Neoplasms/epidemiology , Mass Screening , Adult , Age Distribution , Aged , Aged, 80 and over , Case-Control Studies , Female , Humans , Japan/epidemiology , Lung Neoplasms/etiology , Male , Middle Aged , Odds Ratio , Sex Characteristics , Smoking/adverse effects , Smoking/epidemiology
17.
Nihon Koshu Eisei Zasshi ; 48(7): 534-42, 2001 Jul.
Article in Japanese | MEDLINE | ID: mdl-11524828

ABSTRACT

In order to clarify functional characteristics of pharmacy services related to home care in a suburban area, a questionnaire survey regarding home-care services was conducted for all 75 pharmacies belonged to T-City Pharmaceutical Association. The following services were investigated; A) prescription (medication guidance for patients and their families, provision of drug information to patients, management of the patient's drug history, dispensing, advice to physicians, inquiries, management of prescriptions for home infusion services); B) supply (sales of items such as over-the-counter [OTC] drugs [commercially available drugs that do not require a physician's prescription], display and catalogue sales of nursing items); C) consultation (consultation on home care, holding events such as health education programs); D) management (guidance for drug management by home visit); and E) information exchange (information exchange with other medical professionals and social workers). The results of the present study were as follows. (1) The following services were considered important and therefore regularly performed; A) prescription: medication guidance for patients and their families, provision drug information to patients, management of the patient's drug history, dispensing, advice to physicians, inquiries; and B) supply: sales of items such as OTC drugs. (2) The following services were considered important, but not sufficiently regularly performed; B) supply: display and catalogue sales of nursing items; C) consultation: consultation on home care, holding events such as health education programs; D) management: guidance for drug management by home visits; and E) information exchange. (3) On factor analysis, among home care-related pharmacy services, display and catalogue sales of nursing items as well as consultation on home care were present in the same factor group as contained sales of items such as OTC drugs, which showed a high accomplishment rate. Guidance for drug management by home visits and information exchange with other social workers were present in the same factor group as contained information exchange with other medical professionals, which showed a relatively low accomplishment rate. In summary, home care-related pharmacy services were found to be associated with information exchange and supply/consultation functions. This suggests that to improve home care-related services in pharmacies, information exchange among health, medical practices, and social welfare-associated professionals, not previously promoted, should be stimulated and supported.


Subject(s)
Community Pharmacy Services , Home Care Services , Adult , Drug Prescriptions , Female , Health Education , Humans , Japan , Male , Middle Aged , Referral and Consultation , Suburban Health Services
19.
Nihon Hinyokika Gakkai Zasshi ; 92(5): 560-5, 2001 Jul.
Article in Japanese | MEDLINE | ID: mdl-11517566

ABSTRACT

PURPOSE: To increase the management of self-catheterization in children of school age, a catheter kit consisting of hydrophilic catheter and a packet containing sterilized water was developed. We evaluated the lubricating characteristic and clinical efficacy of this new catheter kit. MATERIALS AND METHODS: The catheter kit used in the study was a pocket-size plastic container in which a polyurethane catheter coated with hydrophilic polymer and a packet containing sterilized water were packed in combination. The lubricating characteristic of catheter was assessed by the measurement of friction value. For clinical assessment, male children aged over 6 years old who were doing self-catheterization at 17 medical institutions nationwide were selected as the subjects. The 32 children who had given informed consent (mean age: 11.6 years old) were asked to use the catheter kit continuously for 1 week. The results were investigated by a questionnaire survey in which the assessment before and after the use was expressed in scores. At the same time, urinalysis and urine culture were examined. RESULTS: The friction value of hydrophilic catheter was equivalent to or less than that observed by applying a lubricant to the conventional catheter. The comparison of conventional catheter with the kit indicated significantly higher scores (assessment in 5 grades expressed in scores) for the portability and operability of the kit. Though there was no significant difference in the ease of insertion between the two catheters, there were several comments that the kit got stuck in the urethra when it was withdrawn. The global assessment gave a significantly higher score to the kit and 30 (94%) of the 32 children wanted to use the kit continuously. No increase in hematuria which caused a clinical problem or no new apparent urinary tract infection occurred after the use of the kit. CONCLUSIONS: Compared with the conventional catheter, the hydrophilic catheter kit highly satisfied a large number of children at the time of self-catheterization. Depending on the condition of children, the kit is considered useful for continued self-catheterization for a long term.


Subject(s)
Self Care , Urinary Catheterization/standards , Child , Disposable Equipment/standards , Humans , Male , Urinary Catheterization/instrumentation , Urologic Diseases/therapy
20.
Int Arch Occup Environ Health ; 73 Suppl: S90-2, 2000 Jun.
Article in English | MEDLINE | ID: mdl-10968567

ABSTRACT

Fluoride (F) complexes are used in some fields of industry and medicine. F excretion mainly depends on kidney function. Urinary F concentration is measured to monitor the health of workers exposed to F. The toxicokinetics of F were studied by analyzing plasma concentration of F after intravenous injection of 2.86, 5.71 and 8.57 mg/kg into male Wistar rats. A dose-response relationship was recognized between these F doses and renal tissue injury. Blood samples were removed at 0, 10, 20, and 30 min, and after 1, 2, 3, 4, 5, and 6 h after injection. Plasma concentration-vs-time profiles were evaluated by a nonlinear least-squares method for fitting data to polyexponential equations and calculation of relevant pharmacokinetic parameters. Results indicated that a two-compartment model could describe the elimination of F from plasma. The beta rate constant, total plasma clearance (C1) and first-order rate constants (K21, Kel) decreased, and the half-time of the beta-phase (t1/2beta) was significantly prolonged with increasing dose. The kidney is the main target organ for F toxicity. Acute exposure to high doses of F damages renal tissue and causes renal dysfunction. The C1 of F is mainly dependent on renal F excretion. Since severe kidney damage markedly affected the toxicokinetics of F and decreased its elimination, other nephrotoxic indicators and measurement of plasma F concentration are necessary for monitoring high-dose F exposure.


Subject(s)
Fluorides/pharmacokinetics , Fluorides/toxicity , Kidney Diseases/blood , Kidney Diseases/chemically induced , Analysis of Variance , Animals , Biotransformation , Dose-Response Relationship, Drug , Fluorides/blood , Infusions, Intravenous , Least-Squares Analysis , Male , Rats , Rats, Wistar
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