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1.
Sci Rep ; 11(1): 13907, 2021 07 06.
Article in English | MEDLINE | ID: mdl-34230552

ABSTRACT

Successful adaptation to wearing dentures with palatal coverage may be associated with cortical activity changes related to tongue motor control. The purpose was to investigate the brain activity changes during tongue movement in response to a new oral environment. Twenty-eight fully dentate subjects (mean age: 28.6-years-old) who had no experience with removable dentures wore experimental palatal plates for 7 days. We measured tongue motor dexterity, difficulty with tongue movement, and brain activity using functional magnetic resonance imaging during tongue movement at pre-insertion (Day 0), as well as immediately (Day 1), 3 days (Day 3), and 7 days (Day 7) post-insertion. Difficulty with tongue movement was significantly higher on Day 1 than on Days 0, 3, and 7. In the subtraction analysis of brain activity across each day, activations in the angular gyrus and right precuneus on Day 1 were significantly higher than on Day 7. Tongue motor impairment induced activation of the angular gyrus, which was associated with monitoring of the tongue's spatial information, as well as the activation of the precuneus, which was associated with constructing the tongue motor imagery. As the tongue regained the smoothness in its motor functions, the activation of the angular gyrus and precuneus decreased.


Subject(s)
Adaptation, Physiological , Brain/physiology , Magnetic Resonance Imaging , Movement/physiology , Palate/physiology , Tongue/physiology , Adult , Brain Mapping , Female , Humans , Male , Motor Activity/physiology
2.
Front Syst Neurosci ; 13: 52, 2019.
Article in English | MEDLINE | ID: mdl-31632245

ABSTRACT

Recent studies have revealed that hardness perception is determined by visual information along with the haptic input. This study investigated the cortical regions involved in hardness perception modulated by visual information using functional magnetic resonance imaging (fMRI) and multivoxel pattern analysis (MVPA). Twenty-two healthy participants were enrolled. They were required to place their left and right hands at the front and back, respectively, of a mirror attached to a platform placed above them while lying in a magnetic resonance scanner. In conditions SFT, MED, and HRD, one of three polyurethane foam pads of varying hardness (soft, medium, and hard, respectively) was presented to the left hand in a given trial, while only the medium pad was presented to the right hand in all trials. MED was defined as the control condition, because the visual and haptic information was congruent. During the scan, the participants were required to push the pad with the both hands while observing the reflection of the left hand and estimate the hardness of the pad perceived by the right (hidden) hand based on magnitude estimation. Behavioral results showed that the perceived hardness was significantly biased toward softer or harder in >73% of the trials in conditions SFT and HRD; we designated these trials as visually modulated (SFTvm and HRDvm, respectively). The accuracy map was calculated individually for each of the pair-wise comparisons of (SFTvm vs. MED), (HRDvm vs. MED), and (SFTvm vs. HRDvm) by a searchlight MVPA, and the cortical regions encoding the perceived hardness with visual modulation were identified by conjunction of the three accuracy maps in group analysis. The cluster was observed in the right sensory motor cortex, left anterior intraparietal sulcus (aIPS), bilateral parietal operculum (PO), and occipito-temporal cortex (OTC). Together with previous findings on such cortical regions, we conclude that the visual information of finger movements processed in the OTC may be integrated with haptic input in the left aIPS, and the subjective hardness perceived by the right hand with visual modulation may be processed in the cortical network between the left PO and aIPS.

3.
Neuroimage Clin ; 23: 101845, 2019.
Article in English | MEDLINE | ID: mdl-31075556

ABSTRACT

Physical therapists (PTs) are required to obtain an accurate understanding of the physical and mental states of their patients through observational assessment. To perform comprehensive observational assessments of patients' movements, PTs likely need to engage their own neural systems involved in action understanding and theory of mind, such as the action observation network (AON) and the right temporoparietal junction (rTPJ). Both systems are modulated by the observer's actual experience with the observed movements. Although, most PTs do not have physical experience with neurological disabilities, they routinely examine hemiplegic movements in stroke patients, and are thus considered to have acquired pseudoexperience with hemiplegia. We hypothesized that the PTs' pseudoexperience with hemiplegia would modulate the neural system associated with the understanding of others to elaborately comprehend the physical and mental states associated with hemiplegia. To investigate our hypothesis, we recruited 19 PTs and 19 naïve participants (NPs) to undergo functional MRI (fMRI) for cortical activity measurement while viewing videos of hemiplegic (HHM) and non-hemiplegic (non-HHM) hand movements. The participants subsequently viewed the same videos again outside the MRI scanner, and evaluated the observed hand movements via a questionnaire. Compared to the NPs, the PTs showed greater activation in the AON and rTPJ while observing HHMs. Psychophysiological interaction analyses revealed increased connectivity between the rTPJ and AON when the PTs viewed the HHMs. Behavioral analyses further indicated that the PTs more accurately assessed feeling states associated with HHMs than did NPs. These findings suggest that the PTs' pseudoexperience modulates the AON and rTPJ, enabling them to better understand hemiplegia-associated feeling states.


Subject(s)
Hemiplegia/physiopathology , Magnetic Resonance Imaging/methods , Movement/physiology , Photic Stimulation/methods , Physical Therapists , Theory of Mind/physiology , Adult , Comprehension/physiology , Female , Hemiplegia/psychology , Humans , Male , Physical Therapists/psychology , Young Adult
4.
Front Hum Neurosci ; 12: 424, 2018.
Article in English | MEDLINE | ID: mdl-30405378

ABSTRACT

Several studies have demonstrated that observation of a dummy or mirror-reflected hand being stroked or moving at the same time as the hidden hand evokes a feeling that the dummy hand is one's own, such as the rubber hand illusion (RHI) and mirror visual feedback (MVF). Under these conditions, participants also report sensing the tactile stimulation applied to the fake hands, suggesting that tactile perception is modulated by visual information during the RHI and MVF. Previous studies have utilized passive stimulation conditions; however, active touch is more common in real-world settings. Therefore, we investigated whether active touch is also modulated by visual information during an MVF scenario. Twenty-three participants (13 men and 10 women; mean age ± SD: 21.6 ± 2.0 years) were required to touch a polyurethane pad with both hands synchronously, and estimate the hardness of the pad while observing the mirror reflection. When participants observed the mirror reflection of the other hand pushing a softer or harder pad, perceived hardness estimates were significantly biased toward softer or harder, respectively, even though the physical hardness of the pad remained constant. Furthermore, perceived hardness exhibited a strong correlation with finger displacement of the mirrored, but not hidden, hand. The modulatory effects on perceived hardness diminished when participants touched the pad with both hands asynchronously or with their eyes closed. Moreover, participants experienced ownership of the mirrored hand when they touched the pad with both hands synchronously but not asynchronously. These results indicate that hardness estimates were modulated by observation of the mirrored hand during synchronous touch conditions. The present study demonstrates that, similar to passive touch, active touch is also modulated by visual input.

5.
Front Psychol ; 9: 99, 2018.
Article in English | MEDLINE | ID: mdl-29472880

ABSTRACT

Based on the theory of incentive sensitization, the exposure to food stimuli sensitizes the brain's reward circuits and enhances attentional bias toward food. Therefore, reducing attentional bias to food could possibly be beneficial in preventing impulsive eating. The importance of chewing has been increasingly implicated as one of the methods for reducing appetite, however, no studies to investigate the effect of chewing on attentional bias to food. In this study, we investigated whether chewing stimulation (i.e., chewing tasteless gum) reduces attentional bias to food as well as an actual feeding (i.e., ingesting a standardized meal) does. We measured reaction time, gaze direction and gaze duration to assess attentional bias toward food images in pairs of food and non-food images that were presented in a visual probe task (Experiment 1, n = 21) and/or eye-tracking task (Experiment 2, n = 20). We also measured appetite ratings using visual analog scale. In addition, we conducted a control study in which the same number of participants performed the identical tasks to Experiments 1 and 2, but the participants did not perform sham feeding with gum-chewing/actual feeding between tasks and they took a rest. Two-way ANOVA revealed that after actual feeding, subjective ratings of hunger, preoccupation with food, and desire to eat significantly decreased, whereas fullness significantly increased. Sham feeding showed the same trends, but to a lesser degree. Results of the visual probe task in Experiment 1 showed that both sham feeding and actual feeding reduced reaction time bias significantly. Eye-tracking data showed that both sham and actual feeding resulted in significant reduction in gaze direction bias, indexing initial attentional orientation. Gaze duration bias was unaffected. In both control experiments, one-way ANOVAs showed no significant differences between immediately before and after the resting state for any of the appetite ratings, reaction time bias, gaze direction bias, or gaze duration bias. In conclusion, chewing stimulation reduced subjective appetite and attentional bias to food, particularly initial attentional orientation to food. These findings suggest that chewing stimulation, even without taste, odor, or ingestion, may affect reward circuits and help prevent impulsive eating.

6.
J Cogn Neurosci ; 30(3): 307-318, 2018 03.
Article in English | MEDLINE | ID: mdl-29131745

ABSTRACT

Having chosen an item typically increases the subjective value of the chosen item, and people generally enjoy making choices from larger choice sets. However, having too many items to choose from can reduce the value of chosen items-for example, because of conflict or choice difficulty. In this study, we investigated the effects of choice set size on behavioral and neural value updating (revaluation) of the chosen item. In the scanner, participants selected items from choice sets of various sizes (one, two, four, or eight items). After they chose an item, participants rerated the chosen item, and we quantified revaluation by taking the difference of postchoice minus prechoice ratings. Revaluation of chosen items increased up to choice sets of four alternatives but then decreased again for items chosen from choice sets of eight alternatives, revealing both a linear and a quadratic effect of choice set size. At the time of postchoice rating, activation of the ventrolateral pFC (VLPFC) reflected the influence of choice set size on parametric revaluation, without significant relation to either prechoice or postchoice ratings tested separately. Additional analyses revealed relations of choice set size to anterior cingulate and insula activity during actual choice and increased coupling of both regions to revaluation-related VLPFC during postchoice rating. These data suggest that the VLPFC plays a central role in a network that relates choice set size to updating the value of chosen items and integrates choice overload with value-enhancing effects of larger choice sets.


Subject(s)
Choice Behavior/physiology , Prefrontal Cortex/physiology , Adult , Brain Mapping , Female , Humans , Magnetic Resonance Imaging , Male , Prefrontal Cortex/diagnostic imaging , Young Adult
7.
PLoS One ; 11(9): e0162555, 2016.
Article in English | MEDLINE | ID: mdl-27597999

ABSTRACT

A moving cast shadow is a powerful monocular depth cue for motion perception in depth. For example, when a cast shadow moves away from or toward an object in a two-dimensional plane, the object appears to move toward or away from the observer in depth, respectively, whereas the size and position of the object are constant. Although the cortical mechanisms underlying motion perception in depth by cast shadow are unknown, the human MT complex (hMT+) is likely involved in the process, as it is sensitive to motion in depth represented by binocular depth cues. In the present study, we examined this possibility by using a functional magnetic resonance imaging (fMRI) technique. First, we identified the cortical regions sensitive to the motion of a square in depth represented via binocular disparity. Consistent with previous studies, we observed significant activation in the bilateral hMT+, and defined functional regions of interest (ROIs) there. We then investigated the activity of the ROIs during observation of the following stimuli: 1) a central square that appeared to move back and forth via a moving cast shadow (mCS); 2) a segmented and scrambled cast shadow presented beside the square (sCS); and 3) no cast shadow (nCS). Participants perceived motion of the square in depth in the mCS condition only. The activity of the hMT+ was significantly higher in the mCS compared with the sCS and nCS conditions. Moreover, the hMT+ was activated equally in both hemispheres in the mCS condition, despite presentation of the cast shadow in the bottom-right quadrant of the stimulus. Perception of the square moving in depth across visual hemifields may be reflected in the bilateral activation of the hMT+. We concluded that the hMT+ is involved in motion perception in depth induced by moving cast shadow and by binocular disparity.


Subject(s)
Depth Perception/physiology , Motion Perception/physiology , Vision Disparity/physiology , Visual Cortex/physiology , Adult , Cues , Female , Humans , Magnetic Resonance Imaging , Male , Motion , Photic Stimulation , Visual Cortex/anatomy & histology
8.
Behav Brain Res ; 288: 63-70, 2015 Jul 15.
Article in English | MEDLINE | ID: mdl-25882723

ABSTRACT

In the present study, we investigate whether the macaque monkey can perceive motion in depth using a moving cast shadow. To accomplish this, we conducted two experiments. In the first experiment, an adult Japanese monkey was trained in a motion discrimination task in depth by binocular disparity. A square was presented on the display so that it appeared with a binocular disparity of 0.12 degrees (initial position), and moved toward (approaching) or away from (receding) the monkey for 1s. The monkey was trained to discriminate the approaching and receding motion of the square by GO/delayed GO-type responses. The monkey showed a significantly high accuracy rate in the task, and the performance was maintained when the position, color, and shape of the moving object were changed. In the next experiment, the change in the disparity was gradually decreased in the motion discrimination task. The results showed that the performance of the monkey declined as the distance of the approaching and receding motion of the square decreased from the initial position. However, when a moving cast shadow was added to the stimulus, the monkey responded to the motion in depth induced by the cast shadow in the same way as by binocular disparity; the reward was delivered randomly or given in all trials to prevent the learning of the 2D motion of the shadow in the frontal plane. These results suggest that the macaque monkey can perceive motion in depth using a moving cast shadow as well as using binocular disparity.


Subject(s)
Depth Perception , Motion Perception , Animals , Discrimination, Psychological , Female , Illusions , Macaca , Photic Stimulation/methods , Vision Disparity
9.
J Neurophysiol ; 110(8): 1915-29, 2013 Oct.
Article in English | MEDLINE | ID: mdl-23864380

ABSTRACT

Humans and animals value the opportunity to choose by preferring alternatives that offer more rather than fewer choices. This preference for choice may arise not only from an increased probability of obtaining preferred outcomes but also from the freedom it provides. We used human neuroimaging to investigate the neural basis of the preference for choice as well as for the items that could be chosen. In each trial, participants chose between two options, a monetary amount option and a "choice option." The latter consisted of a number that corresponded to the number of everyday items participants would subsequently be able to choose from. We found that the opportunity to choose from a larger number of items was equivalent to greater amounts of money, indicating that participants valued having more choice; moreover, participants varied in the degree to which they valued having the opportunity to choose, with some valuing it more than the increased probability of obtaining preferred items. Neural activations in the mid striatum increased with the value of the opportunity to choose. The same region also coded the value of the items. Conversely, activation in the dorsolateral striatum was not related to the value of the items but was elevated when participants were offered more choices, particularly in those participants who overvalued the opportunity to choose. These data suggest a functional dissociation of value representations within the striatum, with general representations in mid striatum and specific representations of the value of freedom provided by the opportunity to choose in dorsolateral striatum.


Subject(s)
Choice Behavior , Corpus Striatum/physiology , Adult , Brain Mapping , Female , Humans , Male
10.
Neurobiol Learn Mem ; 96(2): 143-9, 2011 Sep.
Article in English | MEDLINE | ID: mdl-21492743

ABSTRACT

Learning is the process of accumulating information. Repetition can make the process of retrieving information more efficient. The mechanisms by which repetition facilitates the retrieval process, however, are not yet clear. Here, we used event-related functional magnetic resonance imaging to investigate the effects of repetition on cued recall. In this study, participants were asked to encode visually presented semantically unrelated word pairs. The word presented on the left side served as the cue, and the word presented on the right side was the target. In the first test phase, participants were presented with the cue and asked to recall the associated word (target) from the study phase. The second test phase was performed 20 min later using the same method. Participants responded orally during the interval between image acquisitions, and no feedback was provided. Neural activity for identical stimuli and responses across the two tests were compared. As compared with the first test phase, the right dorsolateral prefrontal, bilateral inferior parietal, and precuneus regions showed greater activity and the left inferior frontal areas showed reduced activity during the second test phase. These shifts in neural activity that occurred with repetition may reflect the dynamics of the retrieval process.


Subject(s)
Brain/physiology , Mental Recall/physiology , Neurons/physiology , Practice, Psychological , Brain Mapping , Cues , Female , Humans , Image Processing, Computer-Assisted , Magnetic Resonance Imaging , Male , Neuroimaging , Photic Stimulation , Young Adult
11.
Neuroimage ; 54(1): 485-94, 2011 Jan 01.
Article in English | MEDLINE | ID: mdl-20692350

ABSTRACT

Cast shadows can be salient depth cues in three-dimensional (3D) vision. Using a motion illusion in which a ball is perceived to roll in depth on the bottom or to flow in the front plane depending on the slope of the trajectory of its cast shadow, we investigated cortical mechanisms underlying 3D vision based on cast shadows using fMRI techniques. When modified versions of the original illusion, in which the slope of the shadow trajectory (shadow slope) was changed in 5 steps from the same one as the ball trajectory to the horizontal, were presented to participants, their perceived ball trajectory shifted gradually from rolling on the bottom to floating in the front plane as the change of the shadow slope. This observation suggests that the perception of the ball trajectory in this illusion is strongly affected by the motion of the cast shadow. In the fMRI study, cortical activity during observation of the movies of the illusion was investigated. We found that the bilateral posterior-occipital sulcus (POS) and right ventral precuneus showed activation related to the perception of the ball trajectory induced by the cast shadows in the illusion. Of these areas, it was suggested that the right POS may be involved in the inferring of the ball trajectory by the given spatial relation between the ball and the shadow. Our present results suggest that the posterior portion of the medial parietal cortex may be involved in 3D vision by cast shadows.


Subject(s)
Depth Perception/physiology , Motion Perception/physiology , Parietal Lobe/physiology , Size Perception/physiology , Adult , Behavior , Brain Mapping/methods , Female , Frontal Lobe/physiology , Gyrus Cinguli/physiology , Humans , Magnetic Resonance Imaging/methods , Male , Motion Pictures , Temporal Lobe/physiology , Young Adult
12.
Neurosci Lett ; 463(1): 1-5, 2009 Sep 29.
Article in English | MEDLINE | ID: mdl-19631255

ABSTRACT

Many neuropsychological studies have shown that the Digit Symbol Test (DST) of the Wechsler Adult Intelligence Scale (WAIS) is useful for screening for dysfunctions of the brain. However, it remains unclear which brain areas are actually involved in the performance of DST and what brain functions are used for executing this test. In this study, we examined the cortical areas related to cognitive aspects of DST using functional magnetic resonance imaging (fMRI) and determined executive brain functions involved in this test on the basis of fMRI results. Eleven healthy young adults (mean=21.6 years) performed a modified DST (mDST) task and its control task, which required a simple graphomotor response during fMRI data acquisition. The direct comparison of brain activations between the mDST task and the control task revealed greater activations in a fronto-parietal cortical network, including the bilateral inferior frontal sulci, left middle frontal gyrus (close to the frontal eye field) and left posterior parietal cortex. These activations are interpreted as reflecting the visual search process and/or the updating process of working memory during the mDST task execution. Furthermore, we found a positive correlation between the number of correct responses and activations in the bilateral inferior frontal regions, suggesting that these prefrontal areas have a crucial role in the performance of DST in a healthy young adult population.


Subject(s)
Cerebral Cortex/physiology , Intelligence Tests , Neuropsychological Tests , Brain Mapping , Female , Humans , Magnetic Resonance Imaging , Male , Memory, Short-Term , Photic Stimulation , Task Performance and Analysis , Young Adult
13.
Neuropsychologia ; 45(5): 989-96, 2007 Mar 14.
Article in English | MEDLINE | ID: mdl-17030047

ABSTRACT

We used functional magnetic resonance imaging (fMRI) to investigate whether activation in Broca's area is greater during the processing of passive versus active sentences in the brains of healthy subjects. Twenty Japanese native speakers performed a visual sentence comprehension task in which they were asked to read a visually presented sentence and to identify the agent or the patient in the sentence by pressing a button. We found that the processing of passive sentences elicited no greater activation than that of active sentences in Broca's area. However, passive sentences elicited greater activation than active sentences in the left frontal operculum and the inferior parietal lobule. Thus, our neuroimaging results suggest that deficits in the comprehension of passive sentences in Japanese aphasics are induced not by lesions to Broca's area, but to the left frontal operculum and/or the inferior parietal lobule.


Subject(s)
Brain Mapping , Discrimination, Psychological/physiology , Evoked Potentials/physiology , Frontal Lobe/physiology , Mental Processes/physiology , Semantics , Adolescent , Adult , Analysis of Variance , Female , Humans , Language Tests , Magnetic Resonance Imaging , Male , Reference Values
14.
Hum Brain Mapp ; 28(3): 194-204, 2007 Mar.
Article in English | MEDLINE | ID: mdl-16767768

ABSTRACT

In this study of native Korean trilinguals we examined the effect of syntactic similarity between first (L1) and second (L2) languages on cortical activation during the processing of Japanese and English, which are, respectively, very similar to and different from Korean. Subjects had equivalent proficiency in Japanese and English. They performed auditory sentence comprehension tasks in Korean, Japanese, and English during functional MRI (fMRI). The bilateral superior temporal cortex was activated during the comprehension of three languages. The pars triangularis of the left inferior frontal gyrus (IFG) was additionally activated for L2 processing. Furthermore, the right cerebellum, the pars opercularis of the left IFG, and the posteriomedial part of the superior frontal gyrus were activated during the English tasks only. We observed significantly greater activation in the pars opercularis of the left IFG, the right cerebellum, and the right superior temporal cortex during the English than Japanese task; activation in these regions did not differ significantly between Korean and Japanese. Differential activation of the pars opercularis of the left IFG and the right cerebellum likely reflects syntactic distance and differential activation in the right superior temporal cortex may reflect the prosodic distance between English from Korean and Japanese. Furthermore, in the pars oparcularis of the left IFG and the right cerebellum, significant negative correlation between the activation and duration of exposure was observed for English, but not for Japanese. Our research supports the notion that linguistic similarity between L1 and L2 affects the cortical processing of second language.


Subject(s)
Brain Mapping , Cerebral Cortex/physiology , Language , Multilingualism , Speech Perception/physiology , Acoustic Stimulation , Adult , Female , Humans , Image Processing, Computer-Assisted , Korea , Magnetic Resonance Imaging , Male
15.
Neuroimage ; 31(4): 1762-70, 2006 Jul 15.
Article in English | MEDLINE | ID: mdl-16616863

ABSTRACT

This event-related fMRI study was conducted to examine the blood-oxygen-level-dependent responses to the processing of auditory onomatopoeic sounds. We used a sound categorization task in which the participants heard four types of stimuli: onomatopoeic sounds, nouns (verbal), animal (nonverbal) sounds, and pure tone/noise (control). By discriminating between the categories of target sounds (birds/nonbirds), the nouns resulted in activations in the left anterior superior temporal gyrus (STG), whereas the animal sounds resulted in activations in the bilateral superior temporal sulcus (STS) and the left inferior frontal gyrus (IFG). In contrast, the onomatopoeias activated extensive brain regions, including the left anterior STG, the region from the bilateral STS to the middle temporal gyrus, and the bilateral IFG. The onomatopoeic sounds showed greater activation in the right middle STS than did the nouns and environmental sounds. These results indicate that onomatopoeic sounds are processed by extensive brain regions involved in the processing of both verbal and nonverbal sounds. Thus, we can posit that onomatopoeic sounds can serve as a bridge between nouns and animal sounds. This is the first evidence to demonstrate the way in which onomatopoeic sounds are processed in the human brain.


Subject(s)
Auditory Perception/physiology , Brain/physiology , Acoustic Stimulation , Adult , Animals , Birds , Cluster Analysis , Environment , Female , Humans , Image Processing, Computer-Assisted , Male , Nerve Net/physiology , Psychomotor Performance/physiology , Vocalization, Animal
16.
J Gerontol A Biol Sci Med Sci ; 60(3): 380-4, 2005 Mar.
Article in English | MEDLINE | ID: mdl-15860478

ABSTRACT

BACKGROUND: Recent findings of neuroimaging studies indicate that reading aloud and arithmetic calculation activate bilateral dorsolateral prefrontal cortex of humans. The purpose of this study was to measure the effect of reading aloud and arithmetic calculation, by elderly people who were clinically diagnosed with dementia Alzheimer type, on their brain functions and activities of daily living. METHODS: Sixteen experimental and 16 age- and Mini-Mental State Examination score-matched control subjects participated. The participants in the experimental group were asked to perform a training program using learning tasks in reading and arithmetic for 2-6 days a week. The function of the frontal cortex of the subjects was assessed by FAB at bedside (Frontal Assessment Battery). RESULTS: After 6 months of training, the FAB score of the experimental group showed a statistically significant improvement. The FAB score of the control group decreased slightly over the 6-month period, and the difference between the scores of the experimental and control groups was statistically significant. We also observed the restoration of communication and independence in the experimental group. CONCLUSION: Our results indicate that learning tasks of reading aloud and arithmetic calculation can be used for cognitive rehabilitation of dementia patients.


Subject(s)
Dementia/rehabilitation , Frontal Lobe/physiology , Mathematics , Memory Disorders/prevention & control , Reading , Aged , Aged, 80 and over , Aging/physiology , Case-Control Studies , Cognition Disorders/diagnosis , Cognition Disorders/rehabilitation , Dementia/diagnosis , Female , Follow-Up Studies , Geriatric Assessment , Humans , Male , Neuropsychological Tests , Probability , Sensitivity and Specificity , Severity of Illness Index , Task Performance and Analysis , Treatment Outcome
17.
J Cogn Neurosci ; 16(5): 727-41, 2004 Jun.
Article in English | MEDLINE | ID: mdl-15200701

ABSTRACT

In order to separate the cognitive processes associated with phonological encoding and the use of a visual word form lexicon in reading, it is desirable to compare the processing of words presented in a visually familiar form with words in a visually unfamiliar form. Japanese Kana orthography offers this possibility. Two phonologically equivalent but visually dissimilar syllabaries allow the writing of, for example, foreign loanwords in two ways, only one of which is visually familiar. Familiarly written words, unfamiliarly written words, and pseudowords were presented in both Kana syllabaries (yielding six conditions in total) to participants during an fMRI measurement with a silent articulation task (Experiment 1) and a phonological lexical decision task (Experiment 2) using an event-related design. Consistent over two experimental tasks, the three different stimulus types (familiar, unfamiliar, and pseudoword) were found to activate selectively different brain regions previously associated with phonological encoding and word retrieval or meaning. Compatible with the predictions of the dual-route model for reading, pseudowords and visually unfamiliar words, which have to be read using phonological assembly, caused an increase in brain activity in left inferior frontal regions (BA 44/47), as compared to visually familiar words. Visually familiar and unfamiliar words were found to activate a range of areas associated with lexico-semantic processing more strongly than pseudowords, such as the left and right temporo-parietal region (BA 39/40), a region in the left middle/inferior temporal gyrus (BA 20/21), and the posterior cingulate (BA 31).


Subject(s)
Brain/physiology , Linguistics , Magnetic Resonance Imaging , Mental Processes/physiology , Pattern Recognition, Visual/physiology , Reading , Recognition, Psychology/physiology , Adolescent , Adult , Brain/anatomy & histology , Brain Mapping , Factor Analysis, Statistical , Female , Functional Laterality/physiology , Humans , Image Processing, Computer-Assisted , Magnetic Resonance Imaging/methods , Male , Photic Stimulation/methods , Reaction Time/physiology , Visual Fields
18.
Ann Otol Rhinol Laryngol ; 111(7 Pt 1): 593-7, 2002 Jul.
Article in English | MEDLINE | ID: mdl-12126014

ABSTRACT

The regulation of glandular secretions and vasomotor tone in human nasal mucosa implicates muscarinic receptors. There are 5 recognized classes (m1 through m5) of muscarinic receptor subtypes, and the aim of our study was to localize muscarinic receptor subtypes (m1 through m5) in human inferior turbinate mucosa by an immunohistochemical method. We found m1 and m2 receptors distributed on glands, arteries, veins, and epithelia; m4 receptors were found around arteries; and m5 receptors were identified on glands and arteries. We found m3 receptors to be the most extensively distributed on glands, arteries, and veins of all of the muscarinic receptor subtypes. The m3 receptor is probably important in the physiology of the human inferior turbinate. This study may help identify the best target for more selective muscarinic drugs and guide the treatment of allergic and nonallergic rhinitis.


Subject(s)
Nasal Mucosa/cytology , Nasal Mucosa/metabolism , Receptors, Muscarinic/metabolism , Turbinates/cytology , Turbinates/metabolism , Adult , Female , Humans , Immunohistochemistry , Male , Middle Aged , Nerve Fibers/metabolism
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