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Vaccine ; 7(3): 253-6, 1989 Jun.
Article in English | MEDLINE | ID: mdl-2528862

ABSTRACT

Immunogenicity of four plasma-derived hepatitis B vaccines (Merck, Sharp and Dohme, Pasteur, Dutch CLB and Korean Cheil-Sugar) was compared in Thai young adults. After primoimmunization, only the Merck and Pasteur vaccines could achieve greater than 90% seroconversion (i.e. anti-HBs greater than or equal to 10 mIU ml-1) whereas both the CLB and Korean vaccines needed a fourth dose to achieve this level of seroconversion. The anti-HBs titres of both heat-inactivated vaccines (CLB and Korean) were also significantly lower than those of the other two vaccines. We propose that the HBsAg content in both heat-inactivated vaccines should be increased and a booster (fourth) dose should be given in order to enhance their immunogenicities.


Subject(s)
Viral Hepatitis Vaccines/immunology , Adult , Drug Administration Schedule , Female , Hepatitis B Antibodies/biosynthesis , Hepatitis B Vaccines , Humans , Male , Thailand , Viral Hepatitis Vaccines/administration & dosage , Viral Hepatitis Vaccines/adverse effects
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