ABSTRACT
La disfunción cognitiva en la Enfermedad de Parkinson (EP) ha sido sólidamente estudiada; sin embargo, es escaso el conocimiento que se tiene sobre el deterioro cognitivo entre los pacientes con EP sin demencia y su relación con las variables clínicas, la sintomatología neuropsiquiátrica y la capacidad funcional. Consecuentemente, fueron evaluados 52 pacientes con EP sin demencia, 22 de los cuales fueron diagnosticados de deterioro cognitivo leve (DCL), emparejados con 52 personas neurológicamente sanas. Nuestros resultados confirman la existencia de una disfunción en la velocidad de procesamiento de la información, el funcionamiento ejecutivo, la memoria verbal y el procesamiento visoperceptual. Por otro lado, el DCL se asoció con una edad avanzada en el comienzo de la EP, mayor sintomatología neuropsiquiátrica, mayor estrés entre los familiares y mayor tendencia hacia la afectación de la capacidad funcional. El estudio apoya la hipótesis de que disfunciones específicas a nivel neuropsicológico, como la ralentización en el procesamiento de la información, pueden actuar como moduladores del deterioro funcional en la EP (AU)
Cognitive dysfunction in Parkinsons Disease (PD) has been consistently reported, but little is known about cognitive impairment in PD patients without dementia, and its association with clinical characteristics, neuropsychiatric disturbance and functional activities. Therefore, we evaluated 52 non-demented PD patients, 22 of them with mild cognitive impairment (PD-MCI) who were matched with 52 healthy controls. Our results confirm the existence of dysfunction in information processing speed, executive function, verbal memory and visuo-perceptual processing in PD. On the other hand, PD-MCI was associated with advanced age at the onset of PD, more neuropsychiatric symptoms (AU)
Subject(s)
Humans , Male , Female , Neuropsychology/methods , Parkinson Disease/psychology , Cognitive Dissonance , Neuropsychiatry/methods , Neuropsychological Tests/statistics & numerical dataABSTRACT
Cognitive dysfunction in Parkinson's Disease (PD) has been consistently reported, but little is known about cognitive impairment in PD patients without dementia, and its association with clinical characteristics, neuropsychiatric disturbance and functional activities. Therefore, we evaluated 52 non-demented PD patients, 22 of them with mild cognitive impairment (PD-MCI) who were matched with 52 healthy controls. Our results confirm the existence of dysfunction in information processing speed, executive function, verbal memory and visuo-perceptual processing in PD. On the other hand, PD-MCI was associated with advanced age at the onset of PD, more neuropsychiatric symptoms, caregiver stress and functional problems. The study supports the hypothesis that specific neuropsychological impairments may act as modulators of functional impairment in PD, for instance slowness of information processing.
Subject(s)
Cognition Disorders/etiology , Parkinson Disease/complications , Parkinson Disease/psychology , Aged , Female , Humans , Male , Middle Aged , Neuropsychological TestsABSTRACT
We report the case of a 48-year-old woman whose recurrent coital headache ceased following intracranial internal carotid artery aneurysm embolization.
Subject(s)
Carotid Artery, Internal, Dissection/complications , Coitus/physiology , Headache Disorders, Primary/etiology , Intracranial Aneurysm/complications , Angiography, Digital Subtraction , Carotid Artery, Internal/diagnostic imaging , Carotid Artery, Internal/pathology , Carotid Artery, Internal, Dissection/diagnostic imaging , Carotid Artery, Internal, Dissection/pathology , Consciousness Disorders/etiology , Electroencephalography , Embolization, Therapeutic , Female , Headache Disorders, Primary/diagnostic imaging , Headache Disorders, Primary/pathology , Humans , Intracranial Aneurysm/diagnostic imaging , Intracranial Aneurysm/pathology , Magnetic Resonance Angiography , Middle Aged , Seizures/etiology , Treatment OutcomeABSTRACT
In 1995, a surveillance system for prion diseases was set up in the Basque Country, an autonomous region in northern Spain (2.1 million inhabitants). In the period from January 1993 to December 2003, we diagnosed 21 patients with familial prion diseases prospectively and another 4 patients retrospectively. They represent 35% of all the cases referred to the epidemiological registry. Two main possible explanations for this unusual high incidence of familial prion diseases are proposed: first, comprehensive case ascertainment by public health neurologists; second, a probable cluster of the D178N mutation within families of Basque origin related to a still unconfirmed common ancestor. Further genetic and genealogical studies should resolve this issue.
Subject(s)
Prion Diseases/epidemiology , Prion Diseases/genetics , Adult , Aged , Cluster Analysis , Family , Female , Humans , Male , Middle Aged , Mutation/genetics , Pedigree , Population Surveillance , Registries , Spain/epidemiologyABSTRACT
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