[Antisense oligonucleotides: a new class of biologically active molecules]. / Antismyslovye oligonukleotidy--printsipial'no novyi klass aktivnykh molekul.

Data available in literature on the biological activity of antisense oligonucleotides are reviewed with emphasis on the results of tests of the related antitumor and antiasthmatic preparations and the basic novelty of these drugs.

[Immunometabolic effects of interactions involving fat- and water-soluble vitamins in toxic forms of anemia]. / Immunometabolicheskie effekty vzaimodeistviia zhirorastvorimykh i vodorastvorimykh vitaminov pri toksicheskikh formakh anemii.

Phenylhydrazine or sodium nitrite injections reduce the functional metabolic activity of neutrophils (leukocytes) in the peripheral blood, suppress the development of humoral immune response and delayed type hypersensitivity, decrease the energetic potential and the antioxidant status of erythrocytes, and induce the appearance of immunosuppressive activity in these cells. Retinol acetate, tocopherol acetate, and phylloquinone administered in various pair combinations reduce the degree of changes in the parameters of nonspecific resistance and immunological reactivity. Pyridoxine and cobalamin increase the immunomodulating activity of erythrocytes modified by phylloquinone.

[Effect of lysozyme on the functional and metabolic activity of polymorphonuclear leukocytes in the acute blood loss]. / Vliianie lizotsima na funktsional'no-metabolicheskuiu aktivnost' polimorfno-iadernykh leikotsitov v usloviiakh ostroi krovopoteri.

Acute hemorrhage leads to a decrease in the phagocyte number and index, the NBT test parameters, and the NADPH oxidase activity and to an increase in the Ca2+ ATPase activity in polymorphonuclear leukocytes on the peripheral blood. Lysozyme produces effective correction of the above parameters of the functional-metabolic activity of these cells. The drug effect is mediated by cytokines of splenocytes sticking to the glass.

[Immunomodulating effect of pyridoxine, folate, and cobalamin in various forms of anemia]. / Immunomoduliruiushchee deistvie piridoksina, folata i kobalamina pri razlichnykh formakh anemii.

Hemorrhage and toxic lesions of hemopoietic tissues inhibit the development of various types of immune response and induce immunosuppressive properties in light erythrocytes, while not influencing the immunological activity of heavy erythrocytes. The immunomodulant action of pyridoxine, folate and cobalamin in various cases of anemia was observed for the joint (but not for separate) administration of two vitamin preparations; the most pronounced increase in the immune reactivity taking place upon the joint administration of cobalamin and folate.

[Immunomodulating action of the preparations of lipid-soluble vitamins after intensive exercise at low temperature of the environment]. / Immunomoduliruiushchee deistvie preparatov zhirorastvorimykh vitaminov posle intensivnykh fizicheskikh nagruzok, vypolniavshikhsia pri nizkoi temperature okruzhaiushchei sredy.

Preparations of lipid-soluble vitamins (A,E and K) injected separately decrease changes in immunological reactivity and nonspecific resistance of Wistar rats swimming for 4 hours in cold water (10 +/- 2 degrees C). Joint administration of preparations of vitamins A and E or A and K normalized immunological reactivity and nonspecific resistance of rats swimming in cold water. Such effect was not reported in joint administration of E and K vitamins preparations.

[Immunomodulating action of fat-soluble vitamins after intense physical loading at low ambient temperatures]. / Immunomoduliruiushchee deistvie preparatov zhirorastvorimykh vitaminov posle intensivnykh fizicheskikh nagruzok, vypolniavshikhsia pri nizkoi temperature okruzhaiushchei sredy.

Introduced separately, preparations of the fat-soluble vitamins A, E and K decreased the expression of changes in the immunological reactivity and nonspecific resistance of Wistar rats after a 4-h swimming in water at a temperature of 10 +/- 2 degrees C. Joint administration of the vitamin preparations A + E or A + K normalized both the the immunological reactivity and nonspecific resistance of rats after cold swim test, while the joint introduction of vitamins E + K produces no such effect.

[The immunometaboic effects of benfotiamine and riboxine on hemolytic anemia]. / Immunometabolicheskie éffekty, vyzyvaemye befotiaminom i riboksinom, pri gemoliticheskoi anemii.

Single (80 mg/kg) or multiply repeated (30 mg/kg) intramuscular injections of phenylhydrazine decrease the functional activity of mononuclear blood cells and the reduces immunological reactivity of the organism. Benfotiamine and riboxin decrease the extent of changes in the immunological response to a single administration of phenylhydrazine but do not significantly influence the immunological functions impaired by repeated injections of the hemolytic toxin.

[Immune and metabolic effects of carnitine and biotin in hemolytic anemia]. / Immunometabolicheskoe deistvie karnitina i biotina pri gemoliticheskoi anemii.

Single (80 mg/kg) or multiple (3 mg/kg) intramuscular introduction of phenylhydrazine decreases the functional activity of mononuclear blood cells and the immunological reactivity of the organism. Carnitine and biotin do not significantly influence the immunological response to a single administration of phenylhydrazine but noticeably reduce the expression of changes produced by repeated injections of the hemolytic toxin.

[Immunomodulating effects of carbohydrate and lipid metabolism activators in acute cold stress]. / Immunomoduliruiushchee deistvie aktivatorov obmena uglevodov i lipidov pri ostrom kholodovom stresse.

Joint injection of the activators of carbohydrate (thiamine, riboxin) and lipid (carnitin, biotin) metabolism in pairs reduces the expression of the decrease of the functional-metabolic activity of blood leukocytes and the inhibition of the immunological reactivity of organism, caused by air and immersion cooling. The most expressed immunomodulative effect is caused by the joint injection of thiamine and biotin.

[Effects of riboxin, essentiale, and phylloquinone on the immunomodulating and antioxidant effect of laser and magneto-laser irradiation in liver toxicosis induced by gentamycin]. / Vliianie riboksina, éssentsiale i fillokhinona na immunomoduliruiushchee i antioksidantnoe deistvie lazernogo i magnito-lazernogo oblucheniia pri toksicheskom porazhenii pochek, vyzvannom gentamitsinom.

The introduction of gentamycine to Wistar rats leads to the toxic liver damage, suppresses humoral immune response to goat erythrocytes, and induces immunosuppressant properties in erythrocytes (caused by increased lipid peroxidation in their membranes and violated cell energy balance) Under these conditions, a combination of the laser or magneto-laser irradiation with the administration of phylloquinone of riboxin provides for a more effective correction of the immune reaction and antioxidant status as compared to the radiation treatment without drugs or with essential. Elimination of the gentamycine induced immunosuppressant properties of erythrocytes is explained by the ability of phylloquinone and essential to reduce the intensity of lipid peroxidation in the cell membranes and with the ability of riboxin to normalize the cell energy balance. An important factor of immunosuppression development in the case of a toxic liver damage caused by D-galactosamine it the interaction of thrombocytes and light erythrocytes with serum factors. The introduction of essential and riboxin favors this interaction and stimulates the development of immunosuppression in thrombocytes.

[Effect of essentiale and riboxin on immunosuppressive properties of thrombocytes and erythrocytes during liver intoxication]. / Vliianie éssentsiale i riboksina na immunosuppressiruiushchie svoistva trombotsitov i éritrotsitov pri toksicheskom porazhenii pecheni.

An important factor of immunosuppression development in the case of a toxic liver damage caused by D-galactosamine it the interaction of thrombocytes and light erythrocytes with serum factors. The introduction of essentiale and riboxin favors this interaction and stimulates the development of immunosuppression in thrombocytes.

[Immunomodulating and antioxidant effects of vitamins A and E during air and immersion cooling]. / Immunomoduliruiushchee i antioksidantnoe deistvie vitaminov A i E pri vozdushnom i immersionnom okhlazhdenii.

An important factor in the immunosuppression development on cooling is the increase in lipid peroxidation rate in the cell membranes. It was found that vitamins A and E possess a high immunomodulating and antioxidant activity under the acute cold-induced stress conditions. Administration of these vitamins is expedient for patients suffered from cooling in air of by immersion.

[Immunomodulating effect of vitamin A and E preparations during deep local cooling]. / Immunomoduliruiushchee deistvie preparatov vitaminov A i E pri glubokom lokal'nom okhlazhdenii.

It was experimentally established for the first time that cell cytokines of lymphatic nodes play an important role in the immunosuppression development in cases of deep local cooling. Vitamins A and E can be used for correcting the cytokine secretion and the immunocyte sensitivity to their action.

[Menadione and roboxin as inducers of immunomodulating activity of erythrocyte stroma]. / Menadion i riboksin kak induktory imunomoduliruiushchei aktivnosti stromy éritrotsitov.

The erythrocyte stroma of intact rats treated with riboxin can be used, after an additional extracorporal treatment with menadione, as a transaphthogenic softly acting immunostimulant. Introduced into rats with a secondary experimental immunodeficient syndrome caused by indomethacin or gentamycin, this stroma leads to normalization of the humoral immune response to ram erythrocytes.

[Immunomodulating effects of vitamin K preparations and its potentiation by riboxine in acute cold stress]. / Immunomoduliruiushchee deistvie preparatov vitamina K i ego usilenie riboksinom pri ostrom kholodovom stresse.

The vitamin K preparations phylloquinone, menadione, and vikasol produce an immunomodulant effect under acute cold-induced stress conditions. A combination of phylloquinone, menadione and riboxin provides an effective means of correcting the immunological reactivity and antioxidant state under the conditions of immersion cooling. The immunomodulant effect of naphthoquinones and riboxin is correlated with their antioxidant activty.

[The immunomodulating action of erythrocyte carrier-bound plant heteropolysaccharides in immersion cooling]. / Immunomoduliruiushchee deistvie sviazannykh s éritrotsitarnym nositelem rastitel'nykh geteropolisakharidov pri immersionnom okhlazhdenii.

Heteropolysaccharides isolated from the racemes of families Polygonaceae, Tiliaceae, and Asteraceae intensify but do not normalize completely the development of the immune response in rats subjected to immersion (water) cooling. A similar effect is caused by erythrocytes of intact rats treated by heteropolysaccharides extracorporeally. On inclusion of heteropolysaccharides into the erythrocytic stroma of intact and cooled animals normalize the development of the immune response in rats subjected to immersion cooling.

[The pharmacological correction of the antioxidant status and of the immunological reactivity of the body during air and immersion cooling]. / Farmakologicheskaia korrektsiia antioksidantnogo statusa i immunologicheskoi reaktivnosti organizma pri vozdushnom i immersionnom okhladenii.

Beta-carotene, essential, and the heteropolysaccharide of chamomile racemes reduce the manifestation of the antioxidant status and immunological reactivity caused by air and immersion (water) cooling. The effect of the drugs is mediated by various fractions of the erythrocytes.

[The effect of anti-asthmatic preparations on the proliferation of human peripheral mononuclear cells]. / Vliianie antiastmaticheskikh preparatov na proliferatsiiu perifericheskikh mononuklearov cheloveka.

The authors studied the effect of some antiasthmatic drugs (theophylline, budesonide, sodium cromalyne) and beta-carotene in vitro on spontaneous and PHA-induced proliferation of human peripheral blood mononuclears (PBMN). It was found that the drugs had no effect on spontaneous cell proliferation. But budesonide caused a 4-fold and beta-carotene a 6-fold decrease of the index of PHA-stimulated PBMN proliferation. It is concluded that beta-carotene may be used in clinical practice as an anti-inflammatory agent for bronchial asthma treatment.

[The immunomodulating activity of the heteropolysaccharides from German chamomile (Matricaria chamomilla) during air and immersion cooling]. / Immunomoduliruiushchaia aktivnost' geteropolisakharidov romashki aptechnoi pri vozdushnom i immersionnom okhlazhdenii.

Intragastric and parenteral administration of heteropolysaccharides of Matricaria chamomilla L. is found to normalize developing of the immune response upon air cooling and enhance (but do not normalize) this process upon immersion cooling. The immunomodulating effect of the heteropolysaccharides upon cooling is attributed to initiation of immunostimulating properties of heavy erythrocytes (macrocytes), activization of immunoregulation cells of peripheral blood, and increased sensitivity of effector cells to helper signals.

[The immunomodulating and antioxidants actions of plant preparations and abisib in disordered lipid metabolism]. / Immunomoduliruiushchee i antioksidantnoe deistvie fitopreparatov i abisib pri narushenii lipidnogo obmena.

Five intraventricular injections of phytopreparations lohein and abisib in a dose of 0.2 or 0.5 ml stimulated dose-dependently the development of a T-dependent and T-independent immune responses in rats kept on the usual diet, and increased or normalized the development of these processes in rats kept on a atherogenic diet. The drugs lessened lipid peroxidation and the biochemical syndromes of hepatocyte affection in animals given an atherogenic diet. The immunomodulating effect of phytopreparations is mediated by cytokines of adherent and nonadherent splenic cells, the biochemical effects only by cytokines of adherent splenocytes.