Tunable theranostics: innovative strategies in combating oral cancer.

Objective: This study aims to assess and compare the potential of advanced nano/micro delivery systems, including quantum dots, carbon nanotubes, magnetic nanoparticles, dendrimers, and microneedles, as theranostic platforms for oral cancer. Furthermore, we seek to evaluate their respective advantages and disadvantages over the past decade. Materials and Methods: A comprehensive literature search was performed using Google Scholar and PubMed, with a focus on articles published between 2013 and 2023. Search queries included the specific advanced delivery system as the primary term, followed by oral cancer as the secondary term (e.g., "quantum dots AND oral cancer," etc.). Results: The advanced delivery platforms exhibited notable diagnostic and therapeutic advantages when compared to conventional techniques or control groups. These benefits encompassed improved tumor detection and visualization, enhanced precision in targeting tumors with reduced harm to neighboring tissues, and improved drug solubility and distribution, leading to enhanced drug absorption and tumor uptake. Conclusion: The findings suggest that advanced nano/micro delivery platforms hold promise for addressing numerous challenges associated with chemotherapy. By enabling precise targeting of cancerous cells, these platforms have the potential to mitigate adverse effects on surrounding healthy tissues, thus encouraging the development of innovative diagnostic and therapeutic strategies for oral cancer.

Morphometric analysis of odontoid process among Arab population: a retrospective cone beam CT study.

Objective: This study aims to evaluate the feasibility of using cone beam computed tomography (CBCT) scans to assess the odontoid process diameter in the Arab population and to determine whether one or two cortical screws can be used for treating odontoid fractures. Methods: The odontoid process of 142 individuals aged 12-75 years, including 72 males (mean age: 35.5) and 70 females (mean age: 36.2), were analyzed using CBCT scans. The sagittal and coronal CBCT views were used to evaluate the antero-posterior (AP) and transverse diameters of the odontoid process. Results: Males had substantially bigger transverse and AP diameters of the odontoid process than females (p < 0.05 & P < 0.01 respectively). Among the sample, 97 individuals (67.4%) had external transverse diameter (METD) of less than 9 mm which is slightly bigger than that of Indians and 48 individuals (31.83%) had enough room for two 3.5 mm or two 2.7 mm screws as their METD was more than 9 mm like that of Greek and Turkish. Age had no significant impact on the morphometric measurements of the odontoid process. Conclusion: More than sixty percent of the sample had METDs of less than 9 millimeters, indicating that a single 4.5-mm Herbert screw may be suggested for fixing fractured odontoid processes in the Arab population.

Anatomical landscape of oral squamous cell carcinoma: A single cancer center study in UAE.

Objectives: This study aimed to present demographic and clinicopathological aspects of OSCC identified in Pathology service in the UAE over a 13-year period and compare these findings to a cohort of 523 cases of Head and neck squamous cell carcinoma using the Cancer Genome Atlas's cBioPortal database (http://cbioportal.org). Material and methods: Histological examination of all hematoxylin and eosin-stained slides and assessment of all demographic and clinical information from laboratory records were performed on all OSCC diagnosed between 2005 and 2018. Results: Males made up 71.4% of the sample of 231 OSCCs that were evaluated. The patients' average age was 55.38 years. The two most prevalent afflicted sites were the anterior two-thirds of the tongue (57.6%) and the cheek (28.1%). The most prevalent site among smokers were the floor of mouth, cheek, and jaw bones. There was a link between tumor size and numerous anatomical subsites that was shown to be highly significant. OSCC in the FOM was associated with a 25% mortality rate. Patients with OSCC of the anterior tongue and cheek had the best prognosis, with only 15.7% and 15.3% of patients dying during follow-up. Conclusion: The present investigation found a correlation between the diverse clinicopathological characteristics of the various anatomical subsites in OSCC. Different anatomical subsites also displayed varying degrees of gene mutation.

Comparative Analysis of Manual Dexterity of Dental Students at Ajman University following One Academic Year of Preclinical Training Sessions: A Longitudinal Cohort Study.

OBJECTIVES: Dental students must complete two stages of training, namely, preclinical training on phantom head models and clinical training on actual patients to acquire the practical skills required by their Bachelor of Dental Surgery program.Our objectives are to evaluate the level of improvement of the manual skills obtained by third-year dental students after one full academic year of preclinical training courses using dexterity tests under direct and indirect vision and to compare the improvement among male and female dental students under the same conditions. MATERIALS AND METHODS: A total of 72 preclinical students participated in our cohort trial, each of whom was assigned a random identification number that was only known to the researchers. After the beginning of the academic year, the experiment was performed under identical conditions for both the O'Connor Tweezer Dexterity Test and the Purdue Pegboard Test. The examinations were conducted at two distinct times: T0 before phantom laboratory training (the beginning of preclinical sessions) and T1 after phantom laboratory training (9 months after T0). STATISTICAL ANALYSIS: Signed-rank test of Wilcoxon over two separate periods (T0 and T1), comparisons were made between the direct and indirect visual dexterity test scores. In addition, the Mann-Whitney U test was used to compare results across gender. The statistical significance (p-value) was set at below 0.05 with a confidence level of 95%. RESULTS: A statistically significant difference was detected between the T0 and T1 assessments on the Purdue Pegboard Test and the O'Connor Tweezer Dexterity Test for all selected dentistry students in both direct and indirect conditions (p < 0.001). CONCLUSION: Further investigation in other dental departments or schools, particularly those with different entry standards, is required prior to making a definitive conclusion about the use of these dexterity assessments as predictors of prospective dental students' performance.

Characteristics of Suture Materials Used in Oral Surgery: Systematic Review.

BACKGROUND: The aim of this review was to evaluate the most used suture materials with regards to their inflammatory response, their bacterial adhesion, and their physical properties when used to close oral wounds. METHODS: Four databases (PubMed, Scopus, Dentistry & Oral Sciences, and OVID) were searched to retrieve relevant studies from January 1, 2000, to January 31, 2020. RESULTS: Out of the 269 articles, only 13 studies were selected as they were relevant and met the systematic review's protocol. These studies showed that almost all suture materials studies (catgut, polyglycolic acid [PGA] sutures, nylon, expanded polytetrafluoroethylene, and silk sutures) caused bacterial adherence and tissue reaction. In nylon and chromic catgut, the number of bacteria accumulated was lowest. Silk and nylon were found to be more impacted than catgut and PGA in terms of physical characteristics such as tensile strength. PGA, on the other hand, was said to be the most susceptible to knot unwinding. CONCLUSIONS: Following an oral surgical operation, all sutures revealed varied degrees of irritation and microbial accumulation. Nonresorbable monofilament synthetic sutures, however, exhibited less tissue response and less microbial accumulation.

Teeth Whitening and Antibacterial Effects of Juglans regia Bark: A Preliminary Study.

OBJECTIVES: Natural folk medicines with antimicrobial effects have been under investigation during the past decades. The aim of this study was to evaluate the teeth whitening and antimicrobial effects of ethanol extract of Persian walnut "Juglans regia" barks. MATERIALS AND METHODS: Minimum inhibitory concentration (MIC) was determined using a broth microdilution assay which was conducted through a 2-fold serial dilution method, and a whitening experiment was done in vitro on extracted teeth, with a pH test being performed on 2-fold dilutions of the ethanol extract. RESULT: It was found that the MIC for Enterobacter and E. coli and Staphylococcus and Pseudomonas was found to be 5 mg/ml and 2.5 mg/ml, respectively. Both dilutions were found to be acidic, and the extract of Juglans regia bark also demonstrated the ability of teeth whitening. CONCLUSION: This study supports the use of Juglans regia bark as a natural product in dentistry because of the confirmed antimicrobial ability as well as its whitening effect. Clinical Relevance. Herb extract might be incorporated within commercially available kinds of toothpaste to enhance its whitening and antimicrobial effects.

Magnetism in drug delivery: The marvels of iron oxides and substituted ferrites nanoparticles.

In modern drug delivery, seeking a drug delivery system (DDS) with a modifiable skeleton for proper targeting of loaded actives to specific sites in the body is of extreme importance for a successful therapy. Magnetically guided nanosystems, where particles such as iron oxides are guided to specific regions using an external magnetic field, can provide magnetic resonance imaging (MRI) while delivering a therapeutic payload at the same time, which represents a breakthrough in disease therapy and make MNPs excellent candidates for several biomedical applications. In this review, magnetic nanoparticles (MNPs) along with their distinguishable properties, including pharmacokinetics and toxicity, especially in cancer therapy will be discussed. The potential perspective of using other elements within the MNP system to reduce toxicity, improve pharmacokinetics, increase the magnetization ability, improve physical targeting precision and/or widen the scope of its biomedical application will be also discussed.

Concha bullosa, nasal septal deviation, and their impacts on maxillary sinus volume among Emirati people: A cone-beam computed tomography study.

PURPOSE: To determine the prevalence of concha bullosa (CB) and nasal septal deviation (NSD) and their impact on maxillary sinus volume (MSV). MATERIALS AND METHODS: Cone-beam computed tomographic (CBCT) images of 106 Emirati people were used in this study. The direction and angle of septal deviation were calculated. The presence of CB, which could be unilateral, contralateral, or bilateral in relation to the direction of NSD, was also recorded. MSV was measured using reconstructed Digital Imaging and Communication in Medicine images on Dolphin 3D imaging software version 11.8 premium (Dolphin Imaging, Chatsworth, CA, USA). P values <0.05 were considered to indicate statistical significance. RESULTS: CB was detected in 37.7% of the sample; 20.7% of the sample showed single unilateral CB and 16.6% had single bilateral CB. NSD was seen in 74.5% of the sample. In the participants with CB, 45.5% showed mild deviation, 34.4% showed moderate deviation, and only 12.5% showed severe septal deviation. CB, but not NSD, was associated with significantly higher MSV on the affected side (P=0.001). CONCLUSION: Although NSD was observed in more than two-thirds of the sample and CB was present in more than one-third of the sample, only CB had a significant impact on MSV.

Bone Texture Fractal Dimension Analysis of Ultrasound-Treated Bone around Implant Site: A Double-Blind Clinical Trial.

OBJECTIVES: To evaluate the efficacy of bone texture fractal dimension (FD) analysis method in predicting implant stability from intraoral periapical radiographs using two implant protocols. MATERIALS AND METHODS: A double-blind clinical trial was conducted on 22 subjects who needed dental implants. The participants were randomized into two groups, the control group with standard implant protocol treatment and the intervention group with added low-intensity power ultrasound treatment (LIPUS) besides the standard implant protocol. The FD values of bone density were carried out on the mesial and distal sides of the implant on digital intraoral radiographs using the box-counting method. Both resonance frequency (RF) and fractal dimension (FD) were assessed in three time intervals: after surgery and before and after loading. RESULTS: FD on both the mesial and distal sides serve as very good-to-excellent tests with high validity (ROC area exceeding 0.8) in predicting high implant stability (ISQ ≥ 70). The mesial side measurements were consistently better than the distal side among the intervention groups. The optimum cutoff value for the FD-mesial side that predicts a highly stable implant (ISQ ≥ 70) is ≥1.505. At this optimum cutoff value, the mesial side FD is associated with a perfect sensitivity (100%) and fairly high specificity (86.5%). CONCLUSION: The FD analysis could be recommended as an adjunctive quantitative method in prediction of the implant stability with very high sensitivity and specificity. This trial is registered with ISRCTN72648040.

Shisha Smoking Habit among Dental School Students in the United Arab Emirates: Enabling Factors and Barriers.

OBJECTIVES: The objective of the present study was to assess shisha smoking among dental school students in Sharjah, United Arab Emirates (UAE). In addition, the role of suggested barriers and enabling factors in shisha smoking was also evaluated. METHODS: A cross-sectional questionnaire-based survey was conducted at the College of Dental Medicine, University of Sharjah, between February and May 2016. The questions were adapted from previously published water pipe smoking studies. The collected data were analyzed to identify the relationship between shisha smoking and sociodemographic characteristics. Relevant questions were further categorized as enabling factors and barriers for shisha smoking. RESULTS: Three enabling questionnaire items related to social environment were significantly associated with an increased risk of being a current smoker. The most powerful is peer pressure ("friends smoke shisha"), which increased the odds ratio of shisha smoking 11.3 times, followed by smoker sibling with increase in odd ratio by 4.52 times, then the belief of social acceptance with increase in odd ratio by 4.31 times. CONCLUSION: Shisha smoking is a serious problem among university students. Any intervention program in the university curricula should consider teaching students that shisha is no less risky than cigarettes and is addictive.

Spatial analysis of mandibular condyles in patients with temporomandibular disorders and normal controls using cone beam computed tomography.

OBJECTIVES: The aim of the study is to investigate the condylar position and its relation to articular eminence and axial condylar angle in temporomandibular joint disorder (TMD) patients and in normal controls using cone beam computed tomography (CBCT). MATERIALS AND METHODS: CBCT temporomandibular joint (TMJ) images of 70 participants (38 males and 32 females, mean age 26.4 years) were analyzed. They were divided into control group (including 35 subjects) and study group (including 35 subjects). Linear measurements of joint space and condyle determined the condylar position of each TMJ. Articular eminence height and inclination were also measured with axial condylar angle to determine its relation to condylar position. Independent and paired sample t-test was applied to compare between the groups and TMJ sides of the same group at significance level of 0.05. RESULTS: Statistical significant differences were found between males and females of both groups regarding superior joint space (SJS), lateral joint space, A-P, and M-L condyle distance (P < 0.05). SJS, medial joint space (MJS), and eminence angle were greater (P < 0.01) in male's joints with TMD with flatter axial condylar angle (P < 0.05), when compared with normal TMJ counterpart. Females TMJs showed significantly higher values of MJS of affected side when compared with normal counterpart with flatter axial condylar angle (P < 0.05). CONCLUSION: Superior and MJS parameters were the ones that showed significant differences between affected and nonaffected joints. The mean axial condylar angle was smaller in joints with abnormal TMJ. This indicates that the condyles of the affected joints may rotate inward.

Evaluation of maxillary sinus dimensions in gender determination using helical CT scanning.

Gender determination is an important step in identification in forensic medicine. CT measurements of maxillary sinuses may be useful to support gender identification. This study was undertaken to study the accuracy and reliability of maxillary sinus dimensions measurement in gender classification through the use of reconstructed helical CT images. Eighty-eight patients (43 men and 45 women) with age range from 20 to 49 years were selected in this study. The width, length, and height of the maxillary sinuses in addition to the total distance across both sinuses were measured. Data were subjected to discriminant analysis for gender using multiple regression analysis. Maxillary sinus height was the best discriminant parameter that could be used to study sexual dimorphism with an overall accuracy of 71.6%. Using multivariate analysis, 74.4% of male sinuses and 73.3% of female sinuses were sexed correctly. The overall percentage for sexing maxillary sinuses correctly was 73.9%. It can be concluded that reconstructed CT image can provide valuable measurements for maxillary sinuses and could be used for sexing when other methods of sexing are not conclusive.

Evaluation of frontal sinus and skull measurements using spiral CT scanning: an aid in unknown person identification.

The present study was undertaken to test a simple system for the identification of unknown bodies using spiral CT images of frontal sinus and other skull measurements among selected Iraqi sample. Ninety patients (45 males and 45 females) with age range from 20 to 49 years were selected in this study. Three features and two groups of measurements of frontal sinus and three skull dimensions were obtained from the CT images. Three basic features were F (presence or absence of frontal sinus), S (septum) and S (scalloping). Measurements selected for the study were frontal sinus width, height and anteroposterior length. In addition to measurements of total width, the distance between the highest points of the two sinuses, the distance between the highest points of each sinus to its maximum lateral limit. Skull measurements included; maximum skull length, prostio-bregmatic height and maximum skull width. All data were subjected to a descriptive and discriminative analysis using the SPSS (Version 17.0). The pre-post comparison (number of discordant items) resulted in 95% accurately predicted perfect match for intra-examiner calibration and 90% accurately predicted perfect match for inter-examiners calibration and the result for one discordant item was 5% for intra-examiner calibration and 10% for inter-examiners calibration. The discriminative analysis showed that the ability of the frontal sinus to identify gender was 76.9%, adding the skull measurements to the frontal sinus measurements gave a higher overall classification accuracy for gender (85.9%). Frontal sinus measurements are valuable method in differentiating gender. Adding skull measurements to the frontal sinus measurements can significantly improve accuracy of gender determination using discriminant analysis. CT based films can provide valuable and precise measurements not only for frontal sinus but even for the whole skull that cannot be approached by other means.

Prevalence in digital panoramic radiographs of carotid area calcification among Iraqi individuals with stroke-related disease.

OBJECTIVE: The purpose of this study was to determine the prevalence of carotid calcification on digital dental panoramic tomography in a group of the Iraqi population who have some stroke-related vascular and or metabolic disease. STUDY DESIGN: Digital dental panoramic tomographic images of 157 adult patients of age range 40-80 years having chronic illnesses such as coronary heart diseases, hypertension, type 2 diabetes, and hyperlipidemia and of 43 control subjects (age range 40-71 years, free of systemic diseases) were made and examined for the presence of carotid artery calcification adjacent or just below the intervertebral space between C3, C4, and C5 on both sides of patient's neck. The study group was subclassified into vascular, metabolic, and vascular-metabolic groups. Determinations were made of the prevalence, number, and distribution of carotid area calcifications. Forward stepwise logistic regression analysis was used to determine which risk factor is more liable to develop carotid artery area calcification. RESULTS: The statistical difference between patients with stroke-related diseases (vascular, metabolic, and vascular-metabolic groups) versus patients in the control group was highly significant concerning the prevalence of carotid area calcifications (P < .01). Carotid area calcification was identified in 38.8% of the study group. Bilateral calcifications were observed more than unilateral calcification for both genders (26.6% vs. 13.9% for men; 24.4% vs. 12.8% for women). CONCLUSION: People with stroke-related vascular and/or metabolic diseases have greater prevalence of calcified area calcifications seen on panoramic radiographs than people who are otherwise healthy.

Retromolar space analysis in relation to selected linear and angular measurements for an Iraqi sample.

BACKGROUND: Radiographic diagnosis of the presence, position, and degree of third molar formation is a crucial part of integral treatment planning for the development of this tooth. Shortage of eruption space between lower second molar and the ramus has long been identified as a major factor in the etiology of lower third molar impaction. The purpose of the present investigation was to evaluate the validity of some angular and linear measurements made on digital panoramic imaging to be used as a reference for early prediction of lower third molar eruption or impaction. SUBJECTS AND METHODS: Digital panoramic imaging was done on 50 individuals with full dentition and a class I occlusal relationship. The sample was divided into full-eruption and marginal-eruption groups. Nine variables (linear measurements and angles) were measured for every individual to determine the minimal and maximal values of each variable and these variables were correlated to each other using Pearson's correlation equation. RESULTS: Lower eruption space measurements for the marginal-eruption group were smaller by more than 3 to 4 mm than that of the full-eruption group. The beta-angle, the angle formed between the long axes of lower second and third molars, showed a marked increase in their values (9 degrees to 10 degrees) when the marginal-eruption group is compared to the full-eruption group. CONCLUSION: Third molar angle (alpha-angle), beta-angle, and gonial angle together with lower eruption space measurements are the variables that should be taken into consideration when early prediction of lower third molar eruption is performed.