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1.
Heart Vessels ; 31(9): 1412-7, 2016 Sep.
Article in English | MEDLINE | ID: mdl-26498755

ABSTRACT

Anaortic coronary artery bypass proved to prevent early neurologic injury compared to on-pump CABG. The Cardica PAS-Port(®) is a fully automated device that might be able to perform proximal aorto-venous anastomoses without an increased embolic risk. We evaluated early post-operative neurologic outcome in a matched population following clampless OPCAB (CCAB: either "all-arterial" or with automatically anastomosed venous grafts) or on-pump CABG. 366 consecutive patients were submitted to isolated coronary bypass by a single surgeon experienced in both off and on-pump procedures between January 2009 and December 2013. Of these patients, 223 underwent a clampless off-pump revascularization. After propensity score matching, 143 pairs were selected, who received either off-pump or on-pump surgery. In the off-pump group, CCAB was performed with an all-arterial approach (n = 33) or with automated proximal anastomosis of the venous graft(s) by means of the Cardica PAS-Port(®) connector (n = 110). Neurologic injury was defined as non-reversible (NRNI: lethal coma or stroke) or reversible (RNI: TIA or delirium). Operative mortality was 2.4 % (CCAB 1.4 %; CABG 3.5 %; p = 0.14). The global rate of early neurologic injury was 5.6 % (CCAB 2.1 vs. CABG 9.1 %; p = 0.006). Incidence was 1.4 % for NRNI (CCAB 0 vs. CABG 2.8 %; p = 0.04) and 4.2 % for RNI (CCAB 2.1 vs. CABG 6.3 %; p = 0.06). No differences were found among other major perioperative outcomes. CCAB prevents both early post-operative RNI and NRNI. This result can be achieved with a totally anaortic strategy and also with the aid of a fully automated device for proximal aorto-venous anastomoses.


Subject(s)
Cardiopulmonary Bypass , Cerebrovascular Disorders/prevention & control , Coronary Artery Bypass, Off-Pump , Coronary Artery Bypass/methods , Aged , Cardiopulmonary Bypass/adverse effects , Cardiopulmonary Bypass/mortality , Cerebrovascular Disorders/diagnosis , Cerebrovascular Disorders/etiology , Cerebrovascular Disorders/mortality , Chi-Square Distribution , Coma/etiology , Coma/prevention & control , Coronary Artery Bypass/adverse effects , Coronary Artery Bypass/mortality , Coronary Artery Bypass, Off-Pump/adverse effects , Coronary Artery Bypass, Off-Pump/instrumentation , Coronary Artery Bypass, Off-Pump/mortality , Delirium/etiology , Delirium/prevention & control , Equipment Design , Female , Hospital Mortality , Humans , Ischemic Attack, Transient/etiology , Ischemic Attack, Transient/prevention & control , Logistic Models , Male , Middle Aged , Odds Ratio , Propensity Score , Risk Factors , Stroke/etiology , Stroke/prevention & control , Time Factors , Treatment Outcome
2.
J Card Surg ; 29(3): 325-32, 2014 May.
Article in English | MEDLINE | ID: mdl-24883445

ABSTRACT

OBJECTIVE: To evaluate long-term clinical performance and angiographic patency of automated proximal venous anastomoses following clampless coronary artery bypass (C-CAB). METHODS: Observational study in patients submitted for isolated C-CAB and at least one proximal aortosaphenous anastomosis performed with an automated connector (Cardica PAS-Port) including 152 consecutive patients (165 devices and 199 device-dependent distal anastomoses), with LVEF > 30% and saphenous vein diameter of 4-6 mm. Clinical follow-up was 96% complete (4101/4269 pt-months). Graft patency rate was assessed with 64-slice CT-scan or coronary angiography. Freedom from major adverse cardiac and cerebrovascular events (MACCE) was reported as actuarial probability with 95% confidence limits and venous graft patency as actual rate at every year interval. RESULTS: Early operative mortality was 1.9%; incidence of neurologic injury was zero. Freedom from MACCE was 92.7 ± 2.1 at one year and 85.2 ± 4.8 at five years. The actual patency rate of device-dependent venous grafts was 90%, 85%, 84%, 84%, and 93% for one-, two-, three-, four-, and five-year-old grafts, respectively. CONCLUSIONS: The device is a well-performing system for proximal anastomoses. The incidence of neurologic complications seems to be reduced with this clampless approach. The high patency rate is stable over time.


Subject(s)
Anastomosis, Surgical/instrumentation , Coronary Artery Bypass/methods , Pancreatitis, Graft , Vascular Patency , Aged , Aorta/surgery , Cardiovascular Diseases/epidemiology , Cerebrovascular Disorders/epidemiology , Coronary Angiography , Female , Follow-Up Studies , Humans , Male , Middle Aged , Pancreatitis, Graft/diagnostic imaging , Postoperative Complications/epidemiology , Saphenous Vein/surgery , Time Factors , Tomography, X-Ray Computed , Treatment Outcome
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