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1.
J Gynecol Oncol ; 35(1): e6, 2024 Jan.
Article in English | MEDLINE | ID: mdl-37743059

ABSTRACT

OBJECTIVE: Self-sampled human papillomavirus (HPV) testing is a potential option for cervical cancer screening, but research is scarce in Cambodia. We evaluated the feasibility, accuracy, and acceptability of self-sampled HPV testing using careHPV. METHODS: A cross-sectional study including women aged 20-49 years attending 2 national hospitals in the capital city was conducted. Women underwent both self-sampling and clinician-sampling of specimens, and were then asked to complete an acceptability questionnaire. The paired samples were analyzed for high-risk HPV by careHPV and genotyped by polymerase chain reaction (PCR). RESULTS: A total of 375 women were eligible for inclusion. Based on PCR, 78.9% were negative for HPV in both self and clinician-samples, 9.9% had a complete HPV type match, and 6.1% had all HPV types in clinician-samples also detected in self-samples. In 5.1%, one or more HPV types identified in the clinician-samples were missed in self-samples. When using careHPV, the overall agreement between the 2 sampling methods was 95.7% (95% confidence interval [CI]=95.8-95.6) with good concordance (κ=0.66, 95% CI=0.56-0.76). Nearly 90% of the women preferred clinician-sampling over self-sampling, citing greater comfort, ease, and speed. CONCLUSION: Self-sampled HPV testing using careHPV could be an option for cervical cancer screening in Cambodia; however, it requires periodic quality control of handling procedures. In addition, women's health education regarding the accuracy of self-sampled HPV testing and the importance of follow-up in cases of positive results is needed.


Subject(s)
Papillomavirus Infections , Uterine Cervical Neoplasms , Female , Humans , Cross-Sectional Studies , Early Detection of Cancer/methods , Cambodia , Papillomavirus Infections/diagnosis , Feasibility Studies , Papillomaviridae/genetics , Specimen Handling/methods , Human Papillomavirus Viruses , Vaginal Smears/methods
2.
J Obstet Gynaecol Res ; 45(7): 1260-1267, 2019 Jul.
Article in English | MEDLINE | ID: mdl-30977232

ABSTRACT

AIM: In Cambodia, the Japan Society of Obstetrics and Gynecology and the Cambodian Society of Gynecology and Obstetrics have an on-going project, started in 2015, for cervical cancer prevention and treatment. The project, currently aimed at factory workers, includes a women's health education program that leads into cervical cancer prevention by establishment of a system for early detection and treatment. It begins by health education, screening for human papillomavirus (HPV), followed by colposcopy and quicker treatment of earlier precursor lesions. METHODS: Rates for participant screening, HPV test positivity, cervical intraepithelial neoplasia (CIN) detection and distribution of HPV types were compared between two screening programs, factory-based and hospital-based. Some HPV test samples were divided into two, one of which was sent to Japan for a quality-control check of the Cambodian testing. RESULTS: The factory-based participant screening rate was 19% (128/681). HPV was detected more frequently in the factory-based program participants (12%) than in the hospital-based program participants (5%). Unfortunately, however, the rate of receiving proper secondary colposcopy screening among the HPV-positive females was significantly higher in the hospital-based program (94%) than the factory-based program (40%) (P < 0.001). The Cambodian laboratory HPV testing accuracy was 92.6%. HPV types demonstrated no significant difference between the two prevention programs. CONCLUSION: We could successfully introduce HPV-based screening, starting from health education. However, low rate of screening, especially secondary screening for HPV positive factory workers was identified. Also, HPV testing could be further improved for accuracy through close monitoring.


Subject(s)
Early Detection of Cancer/methods , Gynecology/methods , Health Education/methods , Patient Acceptance of Health Care/statistics & numerical data , Uterine Cervical Neoplasms/prevention & control , Adult , Cambodia , Colposcopy/statistics & numerical data , Female , Health Plan Implementation , Humans , International Cooperation , Japan , Middle Aged , Papillomaviridae , Papillomavirus Infections/diagnosis , Papillomavirus Infections/virology , Program Evaluation , Societies, Medical , Uterine Cervical Neoplasms/virology , Uterine Cervical Dysplasia/prevention & control , Uterine Cervical Dysplasia/virology
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