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7.
Biull Eksp Biol Med ; 84(8): 143-5, 1977 Aug.
Article in Russian | MEDLINE | ID: mdl-332249

ABSTRACT

Experiments were conducted on CBA mice and albino rats. A study was made of the effect of erythrocyte destruction products (EDP) on the content of hemopoietic colony-forming units (CFU), differentiation of stem cells and the erythropoietin production. It was shown that 3 or 4 EDP injections to normal mice or to lethally irradiated (1000 rad) mice after the transplantation of bone marrow cells caused no changes in the CFU level of stem cells differentiation. In case of a daily (for 3 days) administration of EDP to mice before the irradiation (1000 rad) and bone marrow transplantation there was observed an increase of the colonies count in the recipients' spleen on account of the erythroid colonies. EDP injection caused no changes in the erythropoietic activity of the blood serum. A possible role of erythrocyte destruction products in the mechanism of erythropoiesis autoregulation is discussed.


Subject(s)
Erythrocytes/physiology , Erythropoietin/biosynthesis , Mast Cells/drug effects , Animals , Bone Marrow Cells , Bone Marrow Transplantation , Cell Differentiation/drug effects , Cell Division/drug effects , Clone Cells/drug effects , Erythropoiesis/radiation effects , Mice , Mice, Inbred CBA , Rats , Spleen/cytology , Spleen/radiation effects , Time Factors
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